RTECS:UG5775000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

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o - Propionotoluidide, 2 - (propylamino) - , monohydrochloride

RTECS #: UG5775000

CAS #: 1786-81-8

UPDATE: August 2007 MW: 256.81 MF: C₁₃H₂₀N₂O•ClH

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

2 - (Propylamino) - o - propionotoluidide hydrochloride

Citanest hydrochloride

L - 67 hydrochloride

Prilocaine chloride

Prilocaine hydrochloride

Propanamide, N - (2 - methylphenyl) - 2 - (propylamino) - , monohydrochloride

Propitocaine hydrochloride

Xylonest

alpha - Propylamine - 2 - methyl - propionanilide hydrochloride

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 30 mg/kg N/R 29ZVAB -,99,1969
intraperitoneal
rat lethal dose (50 percent kill): 148 mg/kg N/R NIIRDN 6,692,1982
intratracheal
rabbit lethal dose (50 percent kill): 65 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold JPETAB 132,87,1961
intravenous
mouse lethal dose (50 percent kill): 55 mg/kg N/R NIIRDN 6,692,1982
intravenous
rat lethal dose (50 percent kill): 56,600 µg/kg N/R NIIRDN 6,692,1982
intravenous
rabbit lethal dose (50 percent kill): 18 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold JPETAB 132,87,1961
parenteral
man lowest published lethal dose: 12,343 µg/kg/1 hour- intermittent Blood: Hemorrhage JATOD3 10,75,1986
parenteral
rabbit lethal dose (50 percent kill): 750 mg/kg N/R JPETAB 132,87,1961
subcutaneous
mouse lethal dose (50 percent kill): 632 mg/kg N/R NIIRDN 6,692,1982
subcutaneous
rat lethal dose (50 percent kill): 790 mg/kg N/R NIIRDN 6,692,1982

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
BNYMAM 52,222,1976
TOXICOLOGY REVIEW
ENTOX* -,125,2005

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6086;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 2;
Total Number of Employees Exposed 628;
Total Number of Female Employees Exposed 314

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969
BNYMAM Bulletin of the New York Academy of Medicine. (New York Academy of Medicine, 2 E. 103rd St., New York, NY 10029) Ser 2: V.1- 1925-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
JATOD3 Journal of Analytical Toxicology. (Preston Pub. Inc., POB 48312, Niles, IL 60648) V.1- 1977-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)

FDA-proprietary drug

RTECS Compound Description:
Drug
Human Data

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