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Propionitrile, 3 - (dimethylamino) -

RTECS #: UG1575000

CAS #: 1738-25-6

UPDATE: February 2007 MW: 98.17 MF: C5H10N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 3 - (Dimethylamino) propionitrile
  2. 3 - Dimethylaminopropannitril (Czech)
  1. beta - Dimethylaminopropionitrile


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,923,1986
skin
rabbit 		500 mg/24 hour mild 85JCAE -,923,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 500 mg/kg N/R TOVEFN (1),19,1996
intravenous
mouse 		lethal dose (50 percent kill): 180 mg/kg N/R CSLNX* NX#00201
oral
mouse 		lethal dose (50 percent kill): 1,500 mg/kg N/R 85JCAE -,923,1986
oral
rat 		lethal dose (50 percent kill): 2,600 µL/kg N/R AIHAAP 23,95,1962
skin
rabbit 		lethal dose (50 percent kill): 1,410 µL/kg N/R AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 9 mg/m3/122 day- intermittent Brain and Coverings: Other degenerative changes

Cardiac: Other changes

Liver: Other changes 		TOVEFN (1),19,1996
inhalation
rat 		lowest published toxic concentration: 9 mg/m3/122 day- intermittent Kidney, Ureter, and Bladder: Other changes TOVEFN (1),19,1996
inhalation
rat 		lowest published toxic concentration: 9 mg/m3/122 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TOVEFN (1),19,1996
intraperitoneal
rat 		lowest published toxic dose: 500 mg/kg/3 day- intermittent Liver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TOVEFN (1),19,1996
intraperitoneal
rat 		lowest published toxic dose: 182.6 mg/kg/30 day- intermittent Liver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TOVEFN (1),19,1996


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIMETHYLAMINOPROPIONITRILE-air min expos to NIAX NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3293;
Number of Industries 2;
Total Number of Facilities 145;
Number of Occupations 3;
Total Number of Employees Exposed 1,990


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 26, 1978


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown

RTECS Compound Description:
   Primary Irritant

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