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2 - Propenoic acid, 2 - (hydroxymethyl) - 2 - ( ( (1 - oxo - 2 - propenyl) oxy) methyl) - 1,3 - propanediyl ester

RTECS #: UD3370000

CAS #: 3524-68-3

UPDATE: February 2003 MW: 298.32 MF: C14H18O7


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Acrylic acid, triester with pentaerythritol
  2. Aronix M 305
  3. Gafgard 233
  4. Kayarad PET 30
  5. Light Acrylate PE 3A
  6. NK Ester A - TMM 3
  7. NK Ester A - TMM 3L
  8. NK Ester TMM 50T
  1. P 300 (acrylate)
  2. PETA
  3. Pentaerythritol triacrylate
  4. SR 444
  5. SR 444C
  6. Sartomer SR 444
  7. Setalux UV 2242
  8. Tetramethylolmethane triacrylate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		1 mg severe UCDS** 3/28/1972
eye
rabbit 		100 µL/24 hour severe NTIS** OTS0555713
skin
rabbit 		500 mg open irritation test mild UCDS** 3/28/1972
skin
rabbit 		500 mg moderate JTEHD6 19,149,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis mouse lymphocyte 300 µg/L MUTAEX 4,381,1989
micronucleus test mouse lymphocyte 350 µg/L MUTAEX 4,381,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		NTIS** OTS0571348


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 16 gm/kg/80 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease 		JTEHD6 19,149,1986


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 25 mg/kg Behavioral: Ataxia

Gastrointestinal: Other changes

Skin and Appendages: Other: Hair 		NTIS** OTS0555706
oral
rat 		lethal dose (50 percent kill): 1,830 mg/kg Gastrointestinal: Ulceration or bleeding from small intestine

Gastrointestinal: Ulceration or bleeding from large intestine

Gastrointestinal: Other changes 		NTIS** OTS0555713
skin
rabbit 		lethal dose (50 percent kill): 4 mL/kg N/R TXAPA9 28,313,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
guinea pig 		lowest published toxic dose: 5 pph/12 week- intermittent Skin: After topical application: Cutaneous sensitization (experimental) CODEDG 9,55,1983
skin
mouse 		lowest published toxic dose: 16 gm/kg/80 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) NTIS** OTS0546330
skin
rabbit 		lowest published toxic dose: 2 gm/kg/2 week- intermittent Skin: After systemic exposure: Dermatitis, other NTIS** OTS0555406


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1224;
Number of Industries 2;
Total Number of Facilities 56;
Number of Occupations 3;
Total Number of Employees Exposed 138
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1224;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 1;
Total Number of Employees Exposed 62;
Total Number of Female Employees Exposed 41


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for radiation-cured adhesives, coatings, inks, textile products, photo resists, casting
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; on test (prechronic studies), October 2000
NTP Carcinogenesis studies; test completed (peer review), October 2000


REFERENCES:

CODEN
REFERENCE
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used for radiation-cured adhesives, coatings, inks, textile products, photo resists, casting

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

 Click Here for Additional Information about RTECS

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