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2 - Propenamide, 2 - methyl -

RTECS #: UC6475000

CAS #: 79-39-0

UPDATE: August 2008 MW: 85.12 MF: C4H7NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Methylacrylamide
  2. 2 - Methylpropenamide
  3. Amid kyseliny methakrylove (Czech)
  4. Methacrylamide (8CI)
  5. Methacrylic acid amide
  1. Methacrylic amide
  2. Mhoromer BM801
  3. USAF RH - 1
  4. alpha - Methyl acrylic amide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 2,160 mg/kg (6-17 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		NTIS** PB91-208678
oral
mouse 		lowest published toxic dose: 1,440 mg/kg (6-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** PB91-208678
oral
mouse 		lowest published toxic dose: 240 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Musculoskeletal system NTIS** #PB93149284
oral
mouse 		lowest published toxic dose: 4 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB93149284
oral
mouse 		lowest published toxic dose: 2,160 mg/kg (6-17 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		NTIS** #PB91-208678
oral
mouse 		lowest published toxic dose: 1,440 mg/kg (6-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #PB91-208678


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
man 		lowest published toxic concentration: 3 mg/m3 Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		GISAAA 45(10),74,1980
intraperitoneal
mouse 		lethal dose (50 percent kill): 200 mg/kg N/R NTIS** AD277-689
oral
mouse 		lethal dose (50 percent kill): 451 mg/kg N/R ARTODN 47,179,1981
oral
rat 		lethal dose (50 percent kill): 459 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		GISAAA 45(10),74,1980
skin
mouse 		lethal dose (50 percent kill): >6 gm/kg N/R GISAAA 45(10),74,1980
skin
rat 		lethal dose (50 percent kill): >6 gm/kg N/R GISAAA 45(10),74,1980


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
mouse 		lowest published toxic dose: 2,205 mg/kg/21 week- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct NTIS** #PB93149284
oral
mouse 		lowest published toxic dose: 2,160 mg/kg/12 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB91-208678
oral
mouse 		lowest published toxic dose: 1,260 mg/kg/7 day- intermittent Behavioral: Food intake (animal) NTIS** #PB91-208678
oral
mouse 		lowest published toxic dose: 1,440 mg/kg/12 day- intermittent Liver: Changes in liver weight NTIS** #PB91-208678


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
REPTED 25,192,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M5220;
Number of Industries 1;
Total Number of Facilities 55;
Number of Occupations 2;
Total Number of Employees Exposed 1,031


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for improving mar resistance of resins and plastics
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-

Used for improving mar resistance of resins and plastics

RTECS Compound Description:
   Reproductive Effector
   Human Data

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