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2 - Propanol, 1 - (isopropylamino) - 3 - (1 - naphthyloxy) - , hydrochloride

RTECS #: UB7525000

CAS #: 318-98-9

UPDATE: February 2009 MW: 295.84 MF: C16H21NO2•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. REFERENCES:

SYNONYMS:

  1. (+ - ) - Propranolol hydrochloride
  2. (R,S) - Propranolol hydrochloride
  3. 1 - (1 - Naphthyloxy) - 2 - hydroxy - 3 - isopropylaminopropane hydrochloride
  4. 1 - (Isopropylamino) - 3 - (1 - naphthyloxy) - 2 - propanol hydrochloride
  5. 1 - (Isopropylamino) - 3 - (1 - naphthyloxy) propan - 2 - ol hydrochloride
  6. 1 - (Isopropylamino) - 3 - (alpha - naphthoxy) - 2 - propanol hydrochloride
  7. 1 - Isopropylamino - 3 - (1 - naphthoxy) - propan - 2 - ol - hydrochloride
  8. 2 - Propanol, 1 - ( (1 - methylethyl) amino) - 3 - (1 - naphthalenyloxy) - , hydrochloride
  9. AY 64043
  10. Anaprilin
  11. Anapryline
  12. Avlocardyl
  13. Berkolol
  14. Caridorol
  15. DL - Anapriline
  16. DL - Propranolol hydrochloride
  17. Deralin
  18. Dociton
  19. Duranol
  1. Frekven
  2. ICI 45520
  3. Inderal
  4. Inderal LA
  5. Inderal hydrochloride
  6. Inderex
  7. Inderol
  8. Indobloc
  9. KEMI
  10. NSC - 91523
  11. Naprilin
  12. Obsidan
  13. Oposim
  14. Propranolol hydrochloride
  15. Propraratiopharm
  16. Pylapron
  17. Rapynogen
  18. Tesnol
  19. beta - NEG


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
rat 		lowest published toxic dose: 130 mg/kg (7-19 day pregnant) Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Respiratory system 		JPETAB 252,42,1990
intravenous
rabbit 		lowest published toxic dose: 10,500 µg/kg (7 day prior to copulation) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Other measures of fertility 		CCPTAY 12,53,1975
oral
rat 		lowest published toxic dose: 150 mg/kg (8-18 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) PSCHDL 79,148,1983
oral
rat 		lowest published toxic dose: 60 mg/kg (18-22 day pregnant) Reproductive: Effects on newborn: Behavioral PSCHDL 79,148,1983
oral
woman 		lowest published toxic dose: 48 mg/kg (25-34 week pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects

Reproductive: Effects on newborn: Biochemical and metabolic 		JOPDAB 91,808,1977


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
rat 		lowest published toxic dose: 21.3 µg/kg Behavioral: Alteration of operant conditioning PSCHDL 170,102,2003
intraperitoneal
mouse 		lethal dose (50 percent kill): 80 mg/kg N/R JDGRAX 16,171,1985
intraperitoneal
mouse 		lowest published toxic dose: 10 mg/kg Nutritional and Gross Metabolic: Body temperature decrease TXAPA9 190,262,2003
intraperitoneal
mouse 		lethal dose (50 percent kill): 138 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		TOVEFN 2,43,1993
intraperitoneal
mouse 		lowest published toxic dose: 2 mg/kg Behavioral: Analgesia PHREP* 58,680,2006
intraperitoneal
rat 		lethal dose (50 percent kill): 76 mg/kg Behavioral: Muscle weakness

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea 		ARZNAD 26,506,1976
intraperitoneal
rat 		lowest published toxic dose: 0.5 mg/kg Gastrointestinal: Hypermotility, diarrhea BIPBU* 24,995,2001
intraperitoneal
rat 		lowest published toxic dose: 1 mg/kg Cardiac: Other changes FATOAO 50,41,1987
intraperitoneal
rat 		lowest published toxic dose: 1 mg/kg Cardiac: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		FATOAO 52,37,1989
intraperitoneal
rat 		lowest published toxic dose: 3 mg/kg Behavioral: Change in motor activity (specific assay) PSCHDL 169,176,2003
intravenous
dog 		lowest published lethal dose: 22,811 µg/kg Cardiac: Arrythmias (indlucing changes in conduction) JPPMAB 21,488,1969
intravenous
guinea pig 		lowest published lethal dose: 28,100 µg/kg N/R FRPPAO 35,49,1980
intravenous
guinea pig 		lowest published toxic dose: 1 mg/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi EJPHAZ 437,91,2002
intravenous
human 		lowest published toxic dose: 0.1 mg/kg Cardiac: Change in rate

Cardiac: Cardiac output 		FATOAO 44,71,1981
intravenous
man 		lowest published toxic dose: 29 µg/kg/5 minute- intermittent Cardiac: Pulse rate increased without fall in BP

Vascular: BP elevation not characterized in autonomic section 		AEMED3 14,1112,1985
intravenous
mouse 		lethal dose (50 percent kill): 18 mg/kg N/R ARZNAD 27,1022,1977
intravenous
rat 		lethal dose (50 percent kill): 21 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature decrease 		YACHDS 12(Suppl 6),969,1984
intravenous
rat 		lethal dose (50 percent kill): 40 mg/kg N/R FATOAO 49,47,1986
intravenous
rat 		lowest published toxic dose: 0.3 µg/kg Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section 		BJPCBM 145,567,2005
intravenous
rat 		lowest published toxic dose: 0.1 µg/kg Vascular: BP lowering not characterized in autonomic section BJPCBM 145,567,2005
intravenous
rat 		lowest published toxic dose: 1 mg/kg Cardiac: Change in rate

Vascular: BP elevation not characterized in autonomic section

Vascular: BP lowering not characterized in autonomic section 		PHMCAA 74,1,2005
intravenous
rabbit 		lethal dose (50 percent kill): 12,500 µg/kg N/R ARZNAD 27,1022,1977
intravenous
woman 		lowest published lethal dose: 40 µg/kg Cardiac: Arrythmias (indlucing changes in conduction)

Lung, Thorax, or Respiration: Acute pulmonary edema 		AIMDAP 144,173,1984
oral
cat 		lethal dose : >50 mg/kg Gastrointestinal: Nausea or vomiting

Behavioral: Food intake (animal) 		APTOA6 26,343,1968
oral
man 		lowest published lethal dose: 34 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Pulse rate decreased with fall in BP

Vascular: BP lowering not characterized in autonomic section 		DICPBB 22,781,1988
oral
man 		lowest published toxic dose: 4 mg/kg/1 week- intermittent Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea 		DICPBB 16,776,1982
oral
man 		lowest published toxic dose: 857 µg/kg/3 day- intermittent Skin: After systemic exposure: Dermatitis, other ARDEAC 121,1326,1985
oral
man 		lowest published toxic dose: 43 mg/kg Behavioral: Hallucinations, distorted perceptions

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Cyanosis 		SAMJAF 67,1062,1985
oral
man 		lowest published toxic dose: 417 mg/kg/1 year- intermittent Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma PRACAK 229,663,1985
oral
man 		lowest published toxic dose: 1.14 mg/kg Behavioral: Headache

Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section 		EKFAE9 57,38,1994
oral
mouse 		lethal dose (50 percent kill): 320 mg/kg N/R OYYAA2 2,70,1968
oral
mouse 		lethal dose (50 percent kill): 231 mg/kg Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		TOVEFN 2,43,1993
oral
mouse 		lethal dose (50 percent kill): 331 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		TOVEFN 2,43,1993
oral
rat 		lethal dose (50 percent kill): 466 mg/kg N/R ARZNAD 35,1236,1985
oral
rat 		lowest published toxic dose: 20 mg/kg Biochemical: Metabolism (intermediary): Other EJPHAZ 498,219,2004
oral
rat 		lethal dose (50 percent kill): 449 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		TOVEFN 2,43,1993
oral
rabbit 		lethal dose (50 percent kill): 600 mg/kg N/R NIIRDN 6,733,1982
oral
woman 		lowest published lethal dose: 64 mg/kg Behavioral: General anesthetic

Behavioral: Coma

Cardiac: EKG changes not diagnostic of above 		AMSVAZ 210,137,1981
oral
woman 		lowest published toxic dose: 8,400 µg/kg/7 day- intermittent Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Hallucinations, distorted perceptions

Behavioral: Toxic psychosis 		CTOXAO 4,357,1971
oral
woman 		lowest published toxic dose: 160 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Cardiac: Other changes 		AEMED3 16,1381,1987
oral
woman 		lowest published toxic dose: 77 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		AEMED3 14,161,1985
oral
woman 		lowest published toxic dose: 22 mg/kg/4 week- intermittent Brain and Coverings: Encephalitis

Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity) 		JCGADC 8,74,1986
subcutaneous
monkey 		lowest published toxic dose: 0.32 mg/kg Behavioral: Change in psychophysiological tests JPETAB 301,1103,2002
subcutaneous
mouse 		lethal dose (50 percent kill): 208 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature decrease 		YACHDS 12(Suppl 6),969,1984
subcutaneous
rat 		lethal dose (50 percent kill): 115 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature decrease 		YACHDS 12(Suppl 6),969,1984
subcutaneous
rat 		lowest published toxic dose: 5 mg/kg Biochemical: Metabolism (intermediary): Other proteins NEROEW 23,162,2000
subcutaneous
rat 		lowest published toxic dose: 6 mg/kg Behavioral: Alteration of classical conditioning

Behavioral: Change in psychophysiological tests 		PSCHDL 177,438,2005
unreported route
cat 		lowest published toxic dose: 0.5 mg/kg Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section

Vascular: Measurement of regional blood flow 		EKFAE9 58,23,1995
unreported route
rat 		lowest published toxic dose: 5 mg/kg Reproductive: Maternal effects: Uterus, cervix, vagina FATOAO 53,50,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
monkey 		lowest published toxic dose: 285.6 mg/kg/3 week- intermittent Behavioral: Change in motor activity (specific assay) PBBHAU 42,465,1992
oral
rat 		lowest published toxic dose: 16,100 mg/kg/23 week- continuous Brain and Coverings: Changes in brain weight

Lung, Thorax, or Respiration: Changes in lung weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JIMRBV 19,296,1991
oral
rat 		lowest published toxic dose: 0.6 mg/kg/30 day- intermittent Blood: Other changes TOVEFN 2,43,1993
oral
rat 		lowest published toxic dose: 21 mg/kg/6 week- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct TOVEFN 2,43,1993
unreported route
man 		lowest published toxic dose: 9.15 mg/kg/5 day- intermittent Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section 		FATOAO 49,74,1986
unreported route
woman 		lowest published toxic dose: 12.85 mg/kg/5 day- intermittent Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section 		FATOAO 49,74,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
ENTOX* -,267,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.2 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4182;
Number of Industries 1;
Total Number of Facilities 146;
Number of Occupations 7;
Total Number of Employees Exposed 3,627;
Total Number of Female Employees Exposed 2,653


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038)
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908-
AMSVAZ Acta Medica Scandinavica. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) V.52-224, 1919-88.
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.82- 1960-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BIPBU* Biological & pharmaceutical bulletin. (Pharmaceutical Society of Japan, 2-12-15, Shibuya, Shibuya-ku, Tokyo 150-0002, Japan) V.1- 1993-
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8
JCGADC Journal of Clinical Gastroenterology. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036)
JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969-
JIMRBV Journal of International Medical Research. (Cambridge Medical Pub. Ltd., 435/437 Wellingborough Rd., Northampton, NN1 4EZ, UK) V.1- 1972-
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973-
PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959-
PHREP*
PRACAK Practitioner. (Morgan-Grampian Ltd., 40 Beresford St., Woolwich, London SE18 6BQ, UK) V.1- 1868-
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976-
SAMJAF South African Medical Journal. (Medical Assoc. of South Africa, Secy., P.O. Box 643, Cape Town, S. Africa) V.6- 1932-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-

Used as a beta-adrenergic blocking agent

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Reproductive Effector
   Human Data

ALT CAS #: 3506-09-0
ALT CAS #: 146874-86-4
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