RTECS:UA8475000 The Registry of Toxic Effects of Chemical Substances

2 - Propanol, 1 - (tert - butylamino) - 3 - ( (4 - morpholino - 1,2,5 - thiadiazol - 3 - yl) oxy) - , ( - ) - ,maleate (1:1) (salt)

RTECS #: UA8475000

CAS #: 26921-17-5

UPDATE: May 2008 MW: 432.55 MF: C₁₃H₂₄N₄O₃S•C₄H₄O₄

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

( - ) - 1 - (tert - Butylamino) - 3 - ( (4 - morpholino - 1,2,5 - thiadiazol - 3 - yl) oxy) - 2 - propanol maleate

(S) - Timolol hydrogen maleate

Betime

MK 950

Timacor

Timolol hydrogen maleate

Timolol maleate

Timoptic

Timoptol

l - Timolol maleate

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
eye
human lowest published toxic dose: 0.21 mg/kg/1 hour Eye: Other eye effects

Vascular: Measurement of regional blood flow CLPTAT 61,583,1997
eye
human lowest published toxic dose: 0.21 mg/kg/1 hour Lung, Thorax, or Respiration: Other changes LANCAO 345,1604,1995
intraperitoneal
mouse lethal dose (50 percent kill): 300 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea YKYUA6 32,1393,1981
intraperitoneal
mouse lowest published toxic dose: 2 mg/kg Behavioral: Tremor AEPPAE 369,338,2004
intraperitoneal
rat lethal dose (50 percent kill): 381 mg/kg Eye: Ptosis

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea YKYUA6 32,1393,1981
ocular
man lowest published toxic dose: 39 mg/kg/87 week- intermittent Behavioral: Convulsions or effect on seizure threshold AIMDAP 143,1627,1983
ocular
woman lowest published lethal dose: 5 µg/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi JFAPDE 32,97,1991
oral
mouse lethal dose (50 percent kill): 1,137 mg/kg N/R IYKEDH 12,1204,1981
oral
rat lethal dose (50 percent kill): 1,028 mg/kg N/R NIIRDN 6,464,1982
subcutaneous
mouse lethal dose (50 percent kill): 805 mg/kg N/R IYKEDH 12,1204,1981
subcutaneous
rat lethal dose (50 percent kill): 881 mg/kg N/R NIIRDN 6,464,1982

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 52,500 mg/kg/25 week- intermittent Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Changes in structure or function of salivary glands

Kidney, Ureter, and Bladder: Urine volume increased YKYUA6 32,1393,1981
subcutaneous
rat lowest published toxic dose: 3,500 mg/kg/5 week- intermittent Eye: Ptosis

Liver: Changes in liver weight

Blood: Changes in spleen YKYUA6 32,1393,1981

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
ENTOX* -,267,2005

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3219;
Number of Industries 2;
Total Number of Facilities 82;
Number of Occupations 11;
Total Number of Employees Exposed 5,070;
Total Number of Female Employees Exposed 2,032

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908-
CLPTAT Clinical Pharmacology and Therapeutics. (American Society for Clinical Pharmacology and Therapeutics, St. Louis Mo Mosby-Year Book) V.1- 1960-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JFAPDE Journal of Family Practice. (Appleton and Lange, East Norwalk, CT) V.1- 1974-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as a topical beta-blocking agent

FDA-proprietary drug

RTECS Compound Description:
Drug
Human Data

ALT CAS #: 30166-36-0
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SYNONYMS:
( - ) - 1 - (tert - Butylamino) - 3 - ( (4 - morpholino - 1,2,5 - thiadiazol - 3 - yl) oxy) - 2 - propanol maleate (S) - Timolol hydrogen maleate Betime MK 950 Timacor	Timolol hydrogen maleate Timolol maleate Timoptic Timoptol l - Timolol maleate

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
eye human	lowest published toxic dose: 0.21 mg/kg/1 hour	Eye: Other eye effects Vascular: Measurement of regional blood flow	CLPTAT 61,583,1997
eye human	lowest published toxic dose: 0.21 mg/kg/1 hour	Lung, Thorax, or Respiration: Other changes	LANCAO 345,1604,1995
intraperitoneal mouse	lethal dose (50 percent kill): 300 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Lung, Thorax, or Respiration: Dyspnea	YKYUA6 32,1393,1981
intraperitoneal mouse	lowest published toxic dose: 2 mg/kg	Behavioral: Tremor	AEPPAE 369,338,2004
intraperitoneal rat	lethal dose (50 percent kill): 381 mg/kg	Eye: Ptosis Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea	YKYUA6 32,1393,1981
ocular man	lowest published toxic dose: 39 mg/kg/87 week- intermittent	Behavioral: Convulsions or effect on seizure threshold	AIMDAP 143,1627,1983
ocular woman	lowest published lethal dose: 5 µg/kg	Cardiac: Other changes Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi	JFAPDE 32,97,1991
oral mouse	lethal dose (50 percent kill): 1,137 mg/kg	N/R	IYKEDH 12,1204,1981
oral rat	lethal dose (50 percent kill): 1,028 mg/kg	N/R	NIIRDN 6,464,1982
subcutaneous mouse	lethal dose (50 percent kill): 805 mg/kg	N/R	IYKEDH 12,1204,1981
subcutaneous rat	lethal dose (50 percent kill): 881 mg/kg	N/R	NIIRDN 6,464,1982

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 52,500 mg/kg/25 week- intermittent	Behavioral: Somnolence (general depressed activity) Gastrointestinal: Changes in structure or function of salivary glands Kidney, Ureter, and Bladder: Urine volume increased	YKYUA6 32,1393,1981
subcutaneous rat	lowest published toxic dose: 3,500 mg/kg/5 week- intermittent	Eye: Ptosis Liver: Changes in liver weight Blood: Changes in spleen	YKYUA6 32,1393,1981

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		ENTOX* -,267,2005

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X3219; Number of Industries 2; Total Number of Facilities 82; Number of Occupations 11; Total Number of Employees Exposed 5,070; Total Number of Female Employees Exposed 2,032

REFERENCES:
CODEN	REFERENCE
AEPPAE	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIMDAP	Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908-
CLPTAT	Clinical Pharmacology and Therapeutics. (American Society for Clinical Pharmacology and Therapeutics, St. Louis Mo Mosby-Year Book) V.1- 1960-
ENTOX*	Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
IYKEDH	Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JFAPDE	Journal of Family Practice. (Appleton and Lange, East Norwalk, CT) V.1- 1974-
LANCAO	Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
NIIRDN	Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
YKYUA6	Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-