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Propane, 2 - methyl -

RTECS #: TZ4300000

CAS #: 75-28-5

UPDATE: May 2009 MW: 58.14 MF: C4H10


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1,1 - Dimethylethane
  2. 2 - Methylpropane
  3. A 31 (hydrocarbon)
  1. R 600a
  2. Trimethylmethane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 280 mg/m3 Brain and Coverings: Changes in surface EEG TOVEFN (3),38,2000
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 58,600 mg/m3 Lung, Thorax, or Respiration: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TOVEFN (3),38,2000
inhalation
mouse 		lowest published lethal concentration: 1,041 gm/m3/2 hour Behavioral: Excitement JPETAB 58,74,1936
inhalation
mouse 		lowest published toxic concentration: 500,000 mg/m3/2 hour Behavioral: Ataxia TOVEFN (3),38,2000
inhalation
mouse 		lethal concentration (16 percent kill): 530,000 mg/m3/2 hour Behavioral: General anesthetic TOVEFN (3),38,2000
inhalation
mouse 		lethal concentration (50 percent kill): 680,000 mg/m3/2 hour N/R TOVEFN (3),38,2000
inhalation
rat 		lethal concentration (50 percent kill): 57 pph/15 minute Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression 		HUTODJ 1,239,1982
inhalation
rat 		lethal concentration (16 percent kill): 537,000 mg/m3/4 hour Behavioral: General anesthetic TOVEFN (3),38,2000
inhalation
rat 		lethal concentration (50 percent kill): 658,000 mg/m3/4 hour N/R TOVEFN (3),38,2000


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1000 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
FAZMAE 18,365,1974
TOXICOLOGY REVIEW
HUTOX* -,577,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - BELGIUM time-weighted average 1000 ppm ( mg/m3), MAR2002
Occupational Exposure Limit - GERMANY MAK 2400 mg/m3 (1000 mL/m3), 2005
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 500 ppm (1200 mg/m3), APR2007
Occupational Exposure Limit - SWITZERLAND MAK- week 800 ppm (1900 mg/m3), DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1000 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1000 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81851;
Number of Industries 360;
Total Number of Facilities 118,992;
Number of Occupations 199;
Total Number of Employees Exposed 1,193,478
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81851;
Number of Industries 377;
Total Number of Facilities 110,810;
Number of Occupations 233;
Total Number of Employees Exposed 1,795,168;
Total Number of Female Employees Exposed 556,159


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959-
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981-
HUTOX*
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown

RTECS Compound Description:
   Human Data

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