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Pregn - 5 - ene - 16 - carbonitrile, 3 - hydroxy - 20 - oxo - , (3 - beta,16 - alpha) -

RTECS #: TU4536500

CAS #: 1434-54-4

UPDATE: May 2009 MW: 341.54 MF: C22H31NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. REFERENCES:

SYNONYMS:

  1. 16 - alpha - Cyanopregnenolone
  2. 3 - Hydroxy - 20 - oxopregn - 5 - ene - 16 - carbonitrile (3 - beta,16 - alpha) -
  3. PCN
  4. Pregn - 5 - ene - 16 - alpha - carbonitrile, 3beta - hydroxy - 20 - oxo - (6CI,7CI,8CI)
  1. Pregnenolone 16 - alpha - carbonitrile
  2. Pregnenolone - 16 a - carbonitrile
  3. SC 4674


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 20 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TXAPA9 71,254,1983
intraperitoneal
rat 		lowest published toxic dose: 80 mg/kg Liver: Other changes

Immunological Including Allergic: Uncharacterized (multiple organ involvement)

Biochemical: Metabolism (intermediary): Other 		LIFSAK 71,311,2002
intraperitoneal
rat 		lowest published toxic dose: 40 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Other 		TXCYAC 213,237,2005
oral
rat 		lowest published toxic dose: 100 mg/kg Liver: Other changes TOSCF2 94,272,2006
unreported route
rat 		lowest published toxic dose: 100 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins 		TOXID9 78,405,2004


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 1,600 mg/kg/4 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Other 		TOXID9 60,122,2001
intraperitoneal
mouse 		lowest published toxic dose: 150 mg/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TOXID9 90,374,2006
intraperitoneal
mouse 		: 300 mg/kg/3 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TXCYAC 213,227,2005
intraperitoneal
mouse 		lowest published toxic dose: 120 mg/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		JCINAO 113,137,2004
intraperitoneal
rat 		lowest published toxic dose: 400 mg/kg/4 day- intermittent Liver: Changes in liver weight

Endocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		TXAPA9 111,99,1991
intraperitoneal
rat 		lowest published toxic dose: 60 mg/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TXAPA9 193,66,2003
intraperitoneal
rat 		lowest published toxic dose: 300 mg/kg/4 day- intermittent Liver: Liver function tests impaired TXAPA9 180,56,2002
intraperitoneal
rat 		lowest published toxic dose: 300 mg/kg/4 day- intermittent Liver: Changes in liver weight

Endocrine: Differential effect of sex or castration on observed toxicity

Biochemical: Metabolism (intermediary): Other proteins 		TXCYAC 178,209,2002
oral
mouse 		lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Liver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TXAPA9 155,1,1999
oral
mouse 		lowest published toxic dose: 3,780 mg/kg/21 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		TOXID9 72,313,2003
oral
mouse 		lowest published toxic dose: 630 mg/kg/21 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		TXAPA9 188,6,2003
oral
mouse 		lowest published toxic dose: 1,260 mg/kg/21 day- intermittent Liver: Changes in liver weight

Endocrine: Evidence of thyroid hyperfunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		TXAPA9 188,6,2003
oral
rat 		lowest published toxic dose: 336 mg/kg/7 day- continuous Endocrine: Evidence of thyroid hyperfunction

Endocrine: Aldosteronism

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		TXAPA9 160,163,1999
oral
rat 		lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TXAPA9 155,1,1999
oral
rat 		lowest published toxic dose: 2,700 mg/kg/90 day- continuous Liver: Changes in liver weight

Endocrine: Other changes

Endocrine: Changes in thyroid weight 		TOSCF2 50,45,1999
oral
rat 		lowest published toxic dose: 336 mg/kg/7 day- continuous Endocrine: Evidence of thyroid hypofunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		TOXID9 72,313,2003
oral
rat 		lowest published toxic dose: 420 mg/kg/7 day- intermittent Liver: Changes in liver weight

Endocrine: Evidence of thyroid hypofunction 		TOSCF2 65,184,2002
oral
rat 		lowest published toxic dose: 7,980 mg/kg/19 week- continuous Endocrine: Tumors

Tumorigenic: Facilitates action of known carcinogens 		TOXID9 66,187,2002
oral
rat 		lowest published toxic dose: 500 mg/kg/5 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		TOSCF2 94,272,2006
subcutaneous
mouse 		lowest published toxic dose: 300 mg/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) 		BCPCA6 62,161,2001
unreported route
rat 		lowest published toxic dose: 500 mg/kg/5 day- intermittent Liver: Other changes

Endocrine: Other changes

Biochemical: Metabolism (intermediary): Other proteins 		TOXID9 78,405,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
TPHSDY 23,548,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924-
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

RTECS Compound Description:
   Hormone

ALT CAS #: 25875-43-8
ALT CAS #: 107316-48-3
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