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Pregna - 1,4 - diene - 3,11,20 - trione, 17,21 - dihydroxy - , 21 - acetate

RTECS #: TU4154085

CAS #: 125-10-0

UPDATE: December 1996 MW: 400.51 MF: C23H28O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. NIOSH DOCUMENTATION AND SURVEILLANCE:
  4. REFERENCES:

SYNONYMS:

  1. 1,4 - Pregnadien - 17 - alpha,21 - diol - 3,11,20 - trione - 21 - acetate
  2. Cortancyl
  3. Delcortin
  4. Delta - corlin
  5. Deltalone
  6. Ferrosan
  1. Nisone
  2. Prednisone acetate
  3. Prednisone 21 - acetate
  4. Pregna - 1,4 - diene - 3,11,20 - trione, 21 - (acetyloxy) - 17 - hydroxy - (9CI)
  5. delta' - Dehydrocortisone acetate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
mouse 		lowest published toxic dose: 330 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		TXAPA9 56,23,1980
intramuscular
mouse 		lowest published toxic dose: 135 mg/kg (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TXAPA9 56,23,1980


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3270;
Number of Industries 1;
Total Number of Facilities 18;
Number of Occupations 2;
Total Number of Employees Exposed 1,045;
Total Number of Female Employees Exposed 1,045


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Reproductive Effector
   Hormone

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