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Pregna - 4,6 - diene - 3,20 - dione, 17 - hydroxy - 6 - methyl - 16 - methylene - , acetate

RTECS #: TU4141000

CAS #: 2919-66-6

UPDATE: May 2008 MW: 396.57 MF: C25H32O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. 6 - Dehydro - 16 - methylene - 6 - methyl - 17 - acetoxyprogesterone
  2. BDH 1921
  3. MGA 100
  1. MGA 100 (steroid)
  2. Melengestrol acetate
  3. Pregna - 4,6 - diene - 3,20 - dione, 17 - (acetyloxy) - 6 - methyl - 16 - methylene - (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
cattle 		lowest published toxic dose: 16 µg/kg (16 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders JRPFA4 18,193,1969
intravaginal
cattle 		lowest published toxic dose: 120 µg/kg (16 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders JRPFA4 18,193,1969
intravenous
cattle 		lowest published toxic dose: 6,400 ng/kg (16 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders JRPFA4 11,185,1966
intravenous
cattle 		lowest published toxic dose: 12,800 ng/kg (16 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility JRPFA4 11,185,1966
oral
cattle 		lowest published toxic dose: 30 µg/kg (2-16 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) JANSAG 30,433,1970
oral
cattle 		lowest published toxic dose: 366 µg/kg (14-40 week pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JANSAG 30,433,1970
oral
cattle 		lowest published toxic dose: 16,920 µg/kg (20 week prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Effects on fertility: Other measures of fertility 		JANSAG 27,664,1968
oral
cattle 		lowest published toxic dose: 4 µg/kg (16 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders JRPFA4 11,185,1966
oral
cattle 		lowest published toxic dose: 8 µg/kg (16 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility JRPFA4 11,185,1966
oral
domestic animal 		lowest published toxic dose: 37 µg/kg (10 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders JANSAG 70,2935,1992
oral
rat 		lowest published toxic dose: 40 mg/kg (10 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct FESTAS 15,419,1964
oral
rat 		lowest published toxic dose: 5 mg/kg (10 day male) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands FESTAS 15,419,1964
oral
rat 		lowest published toxic dose: 7,500 µg/kg (30 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Maternal effects: Menstrual cycle changes or disorders 		IJEBA6 9,138,1971
oral
rat 		lowest published toxic dose: 7,500 µg/kg (30 day prior to copulation) Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy) IJEBA6 9,138,1971
parenteral
rat 		lowest published toxic dose: 2,500 µg/kg (10 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina IJEBA6 9,138,1971
subcutaneous
rat 		lowest published toxic dose: 490 µg/kg (7 day prior to copulation/7-20 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetal death 		JDSCAE 61,1778,1978
subcutaneous
rat 		lowest published toxic dose: 150 mg/kg (15-20 day pregnant) Reproductive: Effects on newborn: Stillbirth FESTAS 15,419,1964
subcutaneous
rat 		lowest published toxic dose: 1,400 µg/kg (14 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Effects on fertility: Other measures of fertility 		CCPTAY 5,57,1972
subcutaneous
rat 		lowest published toxic dose: 7 mg/kg (14 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina CCPTAY 5,57,1972
subcutaneous
rabbit 		lowest published toxic dose: 120 µg/kg (12 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) PSEBAA 143,681,1973


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rabbit 		lowest published toxic dose: 0.7 mg/kg/5 day- intermittent Endocrine: Other changes

Reproductive: Maternal effects: Uterus, cervix, vagina 		FATOAO 52,44,1989
subcutaneous
rabbit 		lowest published toxic dose: 0.25 mg/kg/5 day- intermittent Endocrine: Other changes

Reproductive: Maternal effects: Uterus, cervix, vagina 		FATOAO 52,44,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 651,1,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9554;
Number of Industries 1;
Total Number of Facilities 282;
Number of Occupations 3;
Total Number of Employees Exposed 3,637


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950-
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942-
JDSCAE Journal of Dairy Science. (American Dairy Science Assoc., 309 W. Clark St., Champaign, IL 61820) V.1- 1917-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-

RTECS Compound Description:
   Reproductive Effector
   Hormone

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