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Pregna - 1,4 - diene - 3,20 - dione, 9 - fluoro - 11 - beta,17,21 - trihydroxy - 16 - alpha - methyl - ,21 - (dihydrogen phosphate)

RTECS #: TU4055000

CAS #: 312-93-6

UPDATE: May 2006 MW: 472.49 MF: C22H30FO8P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. REFERENCES:

SYNONYMS:

  1. Betnelan phosphate
  2. Dexamethasone 21 - orthophosphate
  3. Dexamethasone phosphate
  4. Dexamethasone 21 - phosphate
  1. Neodecadron
  2. Oradexon phosphate
  3. Wymesone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition intraperitoneal
rat 		3 mg/kg JOENAK 62,527,1974


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 200 µg/kg (19-20 day pregnant) Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		BNEOBV 36,1,1979
intraperitoneal
rat 		lowest published toxic dose: 400 µg/kg (19-20 day pregnant) Reproductive: Specific developmental abnormalities: Hepatobiliary system BNEOBV 36,1,1979
oral
rat 		lowest published toxic dose: 600 µg/kg (21-22 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system PSEBAA 140,1360,1972
parenteral
rabbit 		lowest published toxic dose: 1 mg/kg (11-14 day pregnant) Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system 		ANOBAU 49,465,1965
parenteral
rabbit 		lowest published toxic dose: 1 mg/kg (14-17 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) ANOBAU 49,465,1965
parenteral
rabbit 		lowest published toxic dose: 1 mg/kg (22-25 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ANOBAU 49,465,1965
subcutaneous
rat 		lowest published toxic dose: 30 mg/kg (8-13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		EXPEAM 26,1111,1970
subcutaneous
rat 		lowest published toxic dose: 2 mg/kg (1 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on fertility: Other measures of fertility 		ENDOAO 94,1397,1974
subcutaneous
rat 		lowest published toxic dose: 600 µg/kg (17-19 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Respiratory system 		TJADAB 40,433,1989
subcutaneous
rat 		lowest published toxic dose: 600 µg/kg (17-19 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		TJADAB 46,45,1992
subcutaneous
rat 		lowest published toxic dose: 50 µg/kg (17 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system DBRRDB 104,209,1997
subcutaneous
rat 		lowest published toxic dose: 2.2 mg/kg (1-22 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		CEXPB9 30,32,2003
subcutaneous
rat 		lowest published toxic dose: 3.75 mg/kg (6-21 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Stillbirth 		TXCYAC 194,163,2003
subcutaneous
rat 		lowest published toxic dose: 86.1 mg/kg (6-21 day pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects TOXID9 78,96,2004
subcutaneous
rat 		lowest published toxic dose: 2 mg/kg (6-21 day pregnant) Reproductive: Effects on newborn: Other postnatal measures or effects

Reproductive: Effects on newborn: Delayed effects 		TOXID9 78,96,2004


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
rat 		lowest published toxic dose: 800 µg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation BCPCA6 59,1155,2000
oral
mouse 		lethal dose : >1 gm/kg N/R EVHPAZ 43,41,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 36 mg/kg/90 day- intermittent Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response 		EVHPAZ 43,41,1982
subcutaneous
rat 		lowest published toxic dose: 2.2 mg/kg/22 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		CEXPB9 30,32,2003
subcutaneous
rat 		lowest published toxic dose: 6 mg/kg/5 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		DCTODJ 27,389,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3850;
Number of Industries 3;
Total Number of Facilities 130;
Number of Occupations 10;
Total Number of Employees Exposed 5,388;
Total Number of Female Employees Exposed 2,968


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
ANOBAU Bulletin de l'Association des Anatomistes. (U.E.R. Sciences Medicales A., Boite Postale 1080, 54019 Nancy Cedex, France)
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BNEOBV Biology of the Neonate. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.15- 1970-
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
DBRRDB Developmental Brain Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1981-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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