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Pregna - 1,4 - diene - 3,20 - dione, 9 - fluoro - 11 - beta,17,21 - trihydroxy - 16 - beta - methyl -

RTECS #: TU4000000

CAS #: 378-44-9

UPDATE: May 2009 MW: 392.51 MF: C22H29FO5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. REFERENCES:

SYNONYMS:

  1. 16 - beta - Methyl - 1,4 - pregnadiene - 9 - alpha - fluoro - 11 - beta,17 - alpha,21 - triol - 3,20 - dione
  2. 9 - Fluoro - 11 - beta,17,21 - trihydroxy - 16 - beta - methylpregna - 1,4 - diene - 3,20 - dione
  3. 9 - alpha - Fluoro - 16 - beta - methylprednisolone
  4. 9 - alpha - Fluoro - 16 - beta - methyl - 1,4 - pregnadiene - 11 - beta,17 - alpha,21 - triol - 3,20 - dione
  5. 9 - alpha - Fluoro - 11 - beta,17,21 - trihydroxy - 16 - beta - methylpregna - 1,4 - diene - 3,20 - dione
  6. 9 - alpha - Fluoro - 11 - beta,17 - alpha,21 - trihydroxy - 16 - beta - methylpregna - 1,4 - diene - 3,20 - dione
  7. Betamethasone
  1. Betamethazone
  2. Betnelan
  3. Betsolan
  4. Celestone
  5. NSC - 39470
  6. Sch 4831


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
monkey 		lowest published toxic dose: 600 µg/kg (20 week pregnant) Reproductive: Other effects to embryo or fetus AJOGAH 127,261,1977
intramuscular
monkey 		lowest published toxic dose: 1,600 µg/kg (18 week pregnant) Reproductive: Specific developmental abnormalities: Respiratory system ARDSBL 117,377,1978
intramuscular
monkey 		lowest published toxic dose: 1,200 µg/kg (18-19 week pregnant) Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Specific developmental abnormalities: Hepatobiliary system 		AJOGAH 133,677,1979
intramuscular
monkey 		lowest published toxic dose: 5,200 µg/kg (16-18 week pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Endocrine system 		AJOGAH 133,677,1979
intramuscular
rat 		lowest published toxic dose: 2 mg/kg (18-19 day pregnant) Reproductive: Other effects on female DPTHDL 18,14,1992
intramuscular
rat 		lowest published toxic dose: 6 mg/kg (12-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus 		FDTHES 8,89,1993
intramuscular
rabbit 		lowest published toxic dose: 200 µg/kg (19-20 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Respiratory system 		AJOGAH 180,995,1999
intramuscular
rabbit 		lowest published toxic dose: 400 µg/kg (26-27 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical 		ZEGYAX 111,379,1989
intraperitoneal
mouse 		lowest published toxic dose: 50 mg/kg (16-17 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) BNEOBV 77,29,2000
intraperitoneal
rat 		lowest published toxic dose: 1,200 µg/kg (18-20 day pregnant) Reproductive: Other effects to embryo or fetus PEREBL 33,5,1993
intraperitoneal
rat 		lowest published toxic dose: 150 µg/kg (16-18 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic JPEMAO 22,319,1993
subcutaneous
mammal (species unspecified) 		lowest published toxic dose: 69 mg/kg (8-18 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) JIDOAA 35,387,1986
subcutaneous
mammal (species unspecified) 		lowest published toxic dose: 138 mg/kg (8-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		JIDOAA 35,387,1986


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lethal dose (50 percent kill): >4,500 mg/kg N/R YAKUD5 21,2117,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		: 4 mg/kg/3 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		EJPHAZ 540,147,2006
oral
rat 		lowest published toxic dose: 3.36 mg/kg/4 week- intermittent Behavioral: Muscle weakness INJPD2 39,235,2007
skin
mouse 		lowest published toxic dose: 2.67 mg/kg/6 day- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation BPBLEO 29,1862,2006
skin
mouse 		lowest published toxic dose: 4.8 mg/kg/10 day- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation BPBLEO 28,1079,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
EPBEH* 7,57,2005
TOXICOLOGY REVIEW
PHREP* 57,23,2005
TOXICOLOGY REVIEW
ITODC* -,327,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0622;
Number of Industries 1;
Total Number of Facilities 20;
Number of Occupations 2;
Total Number of Employees Exposed 656;
Total Number of Female Employees Exposed 489


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
ARDSBL American Review of Respiratory Disease. (American Lung Assoc., 1740 Broadway, New York, NY 10019) V.80- 1959-
BNEOBV Biology of the Neonate. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.15- 1970-
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
DPTHDL Developmental Pharmacology and Therapeutics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1980-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EPBEH* Epilepsy & Behavior (San Diego, CA : Academic Press) V.1- 2000-
FDTHES Fetal Diagnosis and Therapy (Basel). (S. Karger, Postfach. CH-4009 Basel, Switzerland) V.5- 1990-
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
ITODC*
JIDOAA Experimental Animals. Jikken Dobutso Iho. (Nippon Jikken Dobutsu Gakkai, c/o Keio Gijuku Daigaku Igakubu Jikken Dobutsu Senta, 35 Shinano-machi, Shinjuku-ku, Tokyo 160, Japan) V.1- 1952-
JPEMAO Journal of Perinatal Medicine. (Walter de Gruyter, Inc., 200 Saw Mill River Rd., Hawthorne, NY 10532) V.1- 1973-
PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1967-
PHREP*
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
ZEGYAX Zentralblatt fuer Gynaekologie. (Johann Ambrosius Barth Verlag, Postfach 109, DDR-7010, Leipzig, Ger. Dem. Rep.) V.1- 1877-

NIOSH PROFILE (HORMONES), SRC, 12/79

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Reproductive Effector

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