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Pregna - 1,4 - diene - 3,20 - dione, 9 - fluoro - 11 - beta,16 - alpha,17,21 - tetrahydroxy - ,cyclic 16,17 - acetal with acetone, 21 - (3,3 - dimethylbutyrate)

RTECS #: TU3930000

CAS #: 5611-51-8

UPDATE: December 1997 MW: 532.71 MF: C30H41FO7


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. NIOSH DOCUMENTATION AND SURVEILLANCE:
  4. STATUS IN FEDERAL AGENCIES:
  5. REFERENCES:

SYNONYMS:

  1. Aristospan
  2. CL 34433
  3. Lederspan
  1. TATBA
  2. Triamcinolone hexacetonide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
mouse 		lowest published toxic dose: 2 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 46IEAC -,387,1980
intramuscular
mouse 		lowest published toxic dose: 2 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		JDREAF 58(Spec Iss A),384,1979
intramuscular
mouse 		lowest published toxic dose: 2 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) IMNGBK 13,443,1981
intramuscular
rat 		lowest published toxic dose: 40 mg/kg (10-13 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) 		JOANAY 128,747,1979
intramuscular
rat 		lowest published toxic dose: 40 mg/kg (10-13 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		JOANAY 128,747,1979


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5557;
Number of Industries 1;
Total Number of Facilities 17;
Number of Occupations 3;
Total Number of Employees Exposed 1,088;
Total Number of Female Employees Exposed 744


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
46IEAC "Current Research Trends in Prenatal Craniofacial Development, Proceedings of an International Conference, 1980," Pratt, R.M., and R.L. Christiansen, eds., New York, Elsevier Science Pub. Co., Inc., 1980
IMNGBK Immunogenetics. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1974-
JDREAF Journal of Dental Research. (International Assoc. for Dental Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919-
JOANAY Journal of Anatomy. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.51- 1916-

FDA-proprietary drug

RTECS Compound Description:
   Reproductive Effector
   Hormone

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