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Potassium fluoride

RTECS #: TT0700000

CAS #: 7789-23-3

UPDATE: May 2009 MW: 58.10 MF: FK


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Fluorure de potassium (French)
  1. Potassium fluorure (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis rat bone marrow 100 nmol/L MUREAV 343,67,1995
mutation in microorganisms mouse lymphocyte 500 mg/L (+enzymatic activation step) MUREAV 187,165,1987
mutation in mammalian somatic cells mouse lymphocyte 400 mg/L MUREAV 187,165,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 1,050 mg/kg (1-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities 		DZZEA7 34,484,1979


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 40,030 µg/kg N/R DZZEA7 34,484,1979
intraperitoneal
rat 		lethal dose (50 percent kill): 64 mg/kg N/R XEURAQ UR-154,1951
oral
guinea pig 		lowest published lethal dose: 250 mg/kg N/R 85KYAH 11,1214,1989
oral
rat 		lethal dose (50 percent kill): 245 mg/kg N/R XEURAQ UR-154,1951
subcutaneous
frog 		lowest published lethal dose: 420 mg/kg N/R CRSBAW 124,133,1937


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2.5 mg(F)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
AMSSAQ 400,5,1963


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 2.5 mg(F)/m3 DTLVS* 3,116,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2.5 mg(F)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2.5 mg(F)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 2.5 mg(F)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 2.5 mg(F)/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 2.5 mg(F)/m3, FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 2.5 mg(F)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 2.5 mg(F)/m3, FEB2006
Occupational Exposure Limit - GERMANY MAK 1 mg(F)/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000
Occupational Exposure Limit - MEXICO time-weighted average 2.5 mg(F)/m3, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2.5 mg(F)/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.6 mg(F)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg(HF)/m3, MAC(short term exposure limit) 3 mg(HF)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.2 mg/m3, short term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 2 mg(F)/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 1 mg(F)/m3,KZG- week 4 mg(F)/m3, Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 2.5 mg(F)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2.5 mg(F)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FLUORIDES, INORGANIC-air 10 hour time-weighted average 2.5 mg(F)/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 60410;
Number of Industries 42;
Total Number of Facilities 1,661;
Number of Occupations 33;
Total Number of Employees Exposed 8,493
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 60410;
Number of Industries 37;
Total Number of Facilities 1,419;
Number of Occupations 29;
Total Number of Employees Exposed 22,283;
Total Number of Female Employees Exposed 3,192


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
AMSSAQ Acta Medica Scandinavica, Supplement. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) No.1-730, 1921-88.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DZZEA7 Deutsche Zahnaerztliche Zeitschrift. (Carl Hanser Verlag, Postfach 860420, D-8000 Munich 86, Fed. Rep. Ger.) V.1- 1946-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research and Development Reports. (Rochester, NY)

Used in etching glass, preservative, insecticide, organic synthesis

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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