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Polydimethyl siloxane

RTECS #: TQ2690000

CAS #: 9016-00-6

UPDATE: May 2007 MW: N/R MF: (C2H6OSi)x


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Dimethicone 350
  2. Dow corning 346
  3. Good - rite
  1. Hycar
  2. Poly (oxy (dimethylsilylene) )


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 5 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TJADAB 31,50A,1985


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
rat 		lowest published toxic dose: 1,500 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Endocrine: Tumors 		AMPLAO 67,589,1959


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intrapleural
dog 		lethal dose : >410 mg/kg N/R ANKHEW 33,666,1988
intrapleural
mouse 		lethal dose : >5,500 mg/kg N/R ANKHEW 33,666,1988
intrapleural
rat 		lethal dose : >2 gm/kg N/R ANKHEW 33,666,1988
intraperitoneal
dog 		lethal dose : >410 mg/kg N/R ANKHEW 33,666,1988
intraperitoneal
mouse 		lethal dose : >5,500 mg/kg N/R ANKHEW 33,666,1988
intraperitoneal
rat 		lethal dose : >2 gm/kg N/R ANKHEW 33,666,1988
ocular
rabbit 		lowest published toxic dose: 100 pph Eye: Conjunctiva irritation TOVEFN (6),37,1996
subcutaneous
dog 		lethal dose : >410 mg/kg N/R ANKHEW 33,666,1988
subcutaneous
mouse 		lethal dose : >5,500 mg/kg N/R ANKHEW 33,666,1988
subcutaneous
rat 		lethal dose : >2 gm/kg N/R ANKHEW 33,666,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
mouse 		lowest published toxic dose: 50 gm/kg/10 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* IMM-89051
implant
mouse 		lowest published toxic dose: 50 gm/kg/10 day- continuous Immunological Including Allergic: Decrease in cellular immune response NTPTR* IMM-89051
implant
mouse 		lowest published toxic dose: 50 gm/kg/10 day- continuous Liver: Changes in liver weight

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* IMM-89051
implant
mouse 		lowest published toxic dose: 50 gm/kg/180 day- continuous Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Decrease in cellular immune response 		NTPTR* IMM-89051
implant
mouse 		lowest published toxic dose: 125 gm/kg/30 day- continuous Liver: Other changes

Immunological Including Allergic: Decrease in cellular immune response 		NTPTR* IMM-89051
implant
mouse 		lowest published toxic dose: 50 gm/kg/180 day- continuous Immunological Including Allergic: Increase in cellular immune response NTPTR* IMM-89051


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T1363;
Number of Industries 3;
Total Number of Facilities 52;
Number of Occupations 4;
Total Number of Employees Exposed 310
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7465;
Number of Industries 141;
Total Number of Facilities 14,142;
Number of Occupations 113;
Total Number of Employees Exposed 284,654;
Total Number of Female Employees Exposed 107,989


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AMPLAO AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60. For publisher information, see APLMAS.
ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown

Used as release material, foam preventive, in mechanical fluid, surface-active material

RTECS Compound Description:
   Tumorigen
   Reproductive Effector

 Click Here for Additional Information about RTECS

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