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Polychlorinated biphenyl (aroclor 1260)

RTECS #: TQ1362000

CAS #: 11096-82-5

UPDATE: May 2008 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Arochlor 1260
  2. Aroclor 1260
  3. Chlorodiphenyl (60% Cl)
  1. Clophen A60
  2. Phenoclor DP6


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
rat 		1,080 mg/kg/26 week- continuous APTOD9 19,A16,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 20 mg/kg (1 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders AMBOCX 1,148,1972
intraperitoneal
rat 		lowest published toxic dose: 10 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		EVHPAZ 108,955,2000
intratesticular
rat 		lowest published toxic dose: 400 µg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		EVHPAZ 108,955,2000
oral
mouse 		lowest published toxic dose: 74 mg/kg (62 day prior to copulation/1-10 day pregnant) Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) 		ENVRAL 6,176,1973
oral
rat 		lowest published toxic dose: 1,675 mg/kg (multigenerations) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) FCTXAV 12,63,1974
oral
rat 		lowest published toxic dose: 210 mg/kg (14-20 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects 		ENVRAL 18,437,1979
subcutaneous
mouse 		lowest published toxic dose: 143 mg/kg (21 day after birth) Reproductive: Effects on newborn: Delayed effects ENPBBC 5,54,1975


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 4,380 mg/kg/83 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		JNCIAM 55,1453,1975
oral
rat 		toxic dose : 4,992 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		TXAPA9 75,278,1984
oral
rat 		toxic dose : 360 mg/kg/17 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		CALEDQ 39,59,1988


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 10 mg/kg Endocrine: Other changes

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		EVHPAZ 108,955,2000
intraperitoneal
rat 		lowest published toxic dose: 160 mg/kg Reproductive: Maternal effects: Uterus, cervix, vagina RCOCB8 9,85,1974
intratesticular
rat 		lowest published toxic dose: 400 µg/kg Endocrine: Other changes

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		EVHPAZ 108,955,2000
oral
mouse 		lowest published toxic dose: 500 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum 		TOLED5 148,29,2004
oral
rat 		lethal dose (50 percent kill): 1,315 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea 		FCTXAV 12,63,1974
skin
rabbit 		lowest published lethal dose: 2 gm/kg N/R ARVPAX 14,139,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 150 mg/kg/3 day- intermittent Liver: Changes in liver weight TXAPA9 28,418,1974
oral
dog 		lowest published toxic dose: 910 mg/kg/1 year- continuous Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		ENVRAL 5,249,1972
oral
monkey 		lowest published toxic dose: 448 mg/kg/20 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites 		TXCYAC 66,145,1991
oral
mouse 		lowest published toxic dose: 280 mg/kg/28 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		ENPBBC 4,116,1974
oral
quail 		lowest published toxic dose: 1,260 mg/kg/18 week- continuous Liver: Changes in liver weight

Endocrine: Changes in thyroid weight 		POSCAL 53,125,1974
oral
rat 		lowest published toxic dose: 4,200 µg/kg/7 day- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TXAPA9 26,504,1973
oral
rat 		lowest published toxic dose: 340 mg/kg/35 week- continuous Liver: Other changes

Liver: Changes in liver weight 		AEHLAU 25,354,1972
oral
rat 		lowest published toxic dose: 273 mg/kg/91 day- continuous Behavioral: Change in motor activity (specific assay) TOSCF2 53,377,2000
oral
rat 		lowest published toxic dose: 33.6 mg/kg/28 day- continuous Liver: Fatty liver degeneration

Endocrine: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		JTEHD6 6,421,1980
oral
rat 		lowest published toxic dose: 1,563 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 60,27,2001
oral
rat 		lowest published toxic dose: 1.3 mg/kg/10 day- intermittent Liver: Changes in liver weight TOXID9 60,27,2001
oral
rat 		lowest published toxic dose: 62.5 mg/kg/10 day- intermittent Immunological Including Allergic: Decrease in humoral immune response TOXID9 60,27,2001
skin
rabbit 		lowest published toxic dose: 960 mg/kg/4 week- intermittent Liver: Changes in liver weight

Skin and Appendages: Other: Hair

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments 		TXAPA9 23,563,1972


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 18,43,1978
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 18,43,1978
TOXICOLOGY REVIEW
EVHPAZ 1,105,1972
TOXICOLOGY REVIEW
ARVPAX 14,139,1974
TOXICOLOGY REVIEW
STEVA8 2,305,1974
TOXICOLOGY REVIEW
BISNAS 20,958,1970
TOXICOLOGY REVIEW
ENVRAL 5,249,1972
TOXICOLOGY REVIEW
TIHEEC 16,305,2000
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO POLYCHLORINATED BIPHENYLS-air Carcinogen;
10 hour time-weighted average 0.001 mg/m3 		NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1180;
Number of Industries 2;
Total Number of Facilities 55;
Number of Occupations 2;
Total Number of Employees Exposed 991;
Total Number of Female Employees Exposed 44


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108027)
Used in heat transfer and hydraulic fluids, and lubricants, and insecticide formulations
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 7, 1976 AND BULLETIN 45, 1986
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AMBOCX Ambio. A Journal of the Human Environment. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI.
BISNAS BioScience. (American Institute of Biological Sciences, 1401 Wilson Blvd., Arlington, VA 22209) V.14- 1964-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
ENPBBC Environmental Physiology and Biochemistry. (Copenhagen, Denmark) V.2-5, 1972-75. Discontinued.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
POSCAL Poultry Science. (Poultry Science Assoc., Inc., 309 W. Clark St., Champaign, IL 61820) V.1- 1921-
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1972-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used in heat transfer and hydraulic fluids, and lubricants, and insecticide formulations

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector

 Click Here for Additional Information about RTECS

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