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Podocarpa - 7,13 - dien - 15 - oic acid, 13 - isopropyl - , methyl ester

RTECS #: TP8590000

CAS #: 127-25-3

UPDATE: May 2003 MW: 316.53 MF: C21H32O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Abietic acid, methyl ester
  2. Methyl abietate
  1. Methyl ester of wood rosin
  2. Wood rosin, methyl ester


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
guinea pig 		10%/72 hour open irritation test mild CODEDG 20,41,1989
skin
rabbit 		500 mg/24 hour moderate FCTXAV 12,931,1974


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 12,931,1974
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 12,931,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intradermal
guinea pig 		lowest published toxic dose: 18 mg/kg/9 day- intermittent Skin: After topical application: Cutaneous sensitization (experimental) CODEDG 20,41,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83115;
Number of Industries 25;
Total Number of Facilities 2,499;
Number of Occupations 26;
Total Number of Employees Exposed 23,335
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83115;
Number of Industries 5;
Total Number of Facilities 468;
Number of Occupations 15;
Total Number of Employees Exposed 5,251;
Total Number of Female Employees Exposed 1,791


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.

RTECS Compound Description:
   Natural Product
   Primary Irritant

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