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1 - Piperazinecarboxamide, N,N - diethyl - 4 - methyl - , citrate (1:1)

RTECS #: TL1225000

CAS #: 1642-54-2

UPDATE: February 2006 MW: 391.48 MF: C10H21N3O•C6H8O7


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1 - Diethylcarbamoyl - 4 - methylpiperazine dihydrogen citrate
  2. 1 - Methyl - 4 - diethylcarbamoylpiperazine citrate
  3. 1 - Piperazinecarboxamide, N,N - diethyl - 4 - methyl - , 2 - hydroxy - 1,2,3 - propanetricarboxylate
  4. Banocide
  5. Caritrol
  6. Carricide citrate
  7. Dicarocide
  8. Diethylcarbamazane citrate
  9. Diethylcarbamazine acid citrate
  10. Diethylcarbamazine citrate
  11. Diethylcarbamazine hydrogen citrate
  1. Ditrazin citrate
  2. Ditrazine citrate
  3. Ethodryl citrate
  4. Filazine
  5. Franocide
  6. Franozan
  7. Hetrazan
  8. Loxuran
  9. N,N - Diethyl - 4 - methyl - 1 - piperazine carboxamide citrate
  10. N,N - Diethyl - 4 - methyl - 1 - piperazinecarboxamide dihydrogen citrate (1:1)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,800 mg/kg (8-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) IJMRAQ 60,1529,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 309 mg/m3/4 hour N/R 85GMAT -,63,1982
intraperitoneal
mouse 		lethal dose (50 percent kill): 425 mg/kg N/R IJSBDB 26,748,1987
intravenous
mouse 		lethal dose (50 percent kill): 180 mg/kg N/R CSLNX* NX#00466
oral
mouse 		lethal dose (50 percent kill): 660 mg/kg N/R 29ZVAB -,41,1969
oral
rat 		lethal dose (50 percent kill): 1,400 mg/kg N/R FAZMAE 17,108,1973
subcutaneous
mouse 		lethal dose (50 percent kill): 608 mg/kg N/R NIIRDN 6,306,1982
subcutaneous
rat 		lethal dose (50 percent kill): 1,136 mg/kg N/R NIIRDN 6,306,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 14 mg/kg/7 day- intermittent Nutritional and Gross Metabolic: Changes in: Na

Nutritional and Gross Metabolic: Changes in: Ca

Nutritional and Gross Metabolic: Changes in: P 		BIOKE3 5,125,1995


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1545;
Number of Industries 1;
Total Number of Facilities 611;
Number of Occupations 4;
Total Number of Employees Exposed 5,223;
Total Number of Female Employees Exposed 2,464


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
BIOKE3 Biokemistri. (Klobex Academic Publishers, POB 4216, Ilorin, Nigiria) V.1- 1994-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959-
IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913-
IJSBDB Indian Journal of Chemistry, Section B: Organic Chemistry, Including Medicinal Chemistry. (Publications & Information Directorate, Council of Scientific and Industrial Research (CSIR), Hillside Rd., New Delhi 110 012, India) V.14B- 1976-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)

Used to treat filariasis, loiasis, onchocerciasis and tropical pulmonary eosinophilia

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Reproductive Effector

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