RTECS:TK9200000 The Registry of Toxic Effects of Chemical Substances

Piperazine, 1,4 - bis (1 - formamido - 2,2,2 - trichloroethyl) -

RTECS #: TK9200000

CAS #: 26644-46-2

UPDATE: May 2007 MW: 434.98 MF: C₁₀H₁₄Cl₆N₄O₂

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

1,4 - Bis (1 - formamido - 2,2,2 - trichloroethyl) piperazine

Biformychlorazin

Biformylchlorazin

CA 70203

CELA 50

CELA W 524

CME 74770

CW 524

Compound W

Formamide, N,N' - (1,4 - piperazinediylbis (2,2,2 - trichloroethylidene) ) bis - (8CI,9CI)

Funginex

N,N' - (Piperazinediylbis (2,2,2 - trichloroethylidene) ) bis (formamide)

N,N' - Bis (1 - formamido - 2,2,2 - trichloroethyl) piperazine

Saprol

Triforine

W 524

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lethal concentration (50 percent kill): >4,500 mg/m³/1 hour N/R PEMNDP 9,853,1991
intraperitoneal
rat lethal dose (50 percent kill): >4 gm/kg N/R 85JFAN A413,1983
oral
dog lethal dose (50 percent kill): >2 gm/kg N/R 85JFAN A413,1983
oral
man lowest published toxic dose: 180 無/kg Taste: Change in function AJEMEN 4,554,1986
oral
mouse lethal dose (50 percent kill): >6 gm/kg N/R PEMNDP 9,853,1991
oral
quail lethal dose (50 percent kill): >5 gm/kg N/R PEMNDP 9,853,1991
oral
rat lethal dose (50 percent kill): 6 gm/kg N/R 85ARAE 4,81,1976/1977
skin
rat lethal dose (50 percent kill): >10 gm/kg N/R PEMNDP 9,853,1991
skin
rabbit lethal dose (50 percent kill): >10 gm/kg N/R 85JFAN A413,1983

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
27ZTAP 3,126,1969
TOXICOLOGY REVIEW
MUTAEX 21,93,2006

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,216,1998

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2601;
Number of Industries 1;
Total Number of Facilities 31;
Number of Occupations 4;
Total Number of Employees Exposed 644;
Total Number of Female Employees Exposed 123

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

27ZTAP "Clinical Toxicology of Commercial Products--Acute Poisoning," 3rd ed., Gleason, M.N., et al., eds., Baltimore, Williams and Wilkins, 1969
85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

Used as a systemic fungicide

RTECS Compound Description:
Agricultural Chemical
Human Data

ALT CAS #: 36660-66-9
ALT CAS #: 37273-84-0
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SYNONYMS:
1,4 - Bis (1 - formamido - 2,2,2 - trichloroethyl) piperazine Biformychlorazin Biformylchlorazin CA 70203 CELA 50 CELA W 524 CME 74770 CW 524	Compound W Formamide, N,N' - (1,4 - piperazinediylbis (2,2,2 - trichloroethylidene) ) bis - (8CI,9CI) Funginex N,N' - (Piperazinediylbis (2,2,2 - trichloroethylidene) ) bis (formamide) N,N' - Bis (1 - formamido - 2,2,2 - trichloroethyl) piperazine Saprol Triforine W 524

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lethal concentration (50 percent kill): >4,500 mg/m³/1 hour	N/R	PEMNDP 9,853,1991
intraperitoneal rat	lethal dose (50 percent kill): >4 gm/kg	N/R	85JFAN A413,1983
oral dog	lethal dose (50 percent kill): >2 gm/kg	N/R	85JFAN A413,1983
oral man	lowest published toxic dose: 180 無/kg	Taste: Change in function	AJEMEN 4,554,1986
oral mouse	lethal dose (50 percent kill): >6 gm/kg	N/R	PEMNDP 9,853,1991
oral quail	lethal dose (50 percent kill): >5 gm/kg	N/R	PEMNDP 9,853,1991
oral rat	lethal dose (50 percent kill): 6 gm/kg	N/R	85ARAE 4,81,1976/1977
skin rat	lethal dose (50 percent kill): >10 gm/kg	N/R	PEMNDP 9,853,1991
skin rabbit	lethal dose (50 percent kill): >10 gm/kg	N/R	85JFAN A413,1983

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		27ZTAP 3,126,1969
TOXICOLOGY REVIEW		MUTAEX 21,93,2006

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988	PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION	FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF	PESTICIDES: Supported	RBREV* -,216,1998

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X2601; Number of Industries 1; Total Number of Facilities 31; Number of Occupations 4; Total Number of Employees Exposed 644; Total Number of Female Employees Exposed 123

REFERENCES:
CODEN	REFERENCE
27ZTAP	"Clinical Toxicology of Commercial Products--Acute Poisoning," 3rd ed., Gleason, M.N., et al., eds., Baltimore, Williams and Wilkins, 1969
85ARAE	"Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision
85JFAN	"Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
AJEMEN	American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
FEREAC	Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
MUTAEX	Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
PEMNDP	Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV*	Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998