RTECS:TK6300000 The Registry of Toxic Effects of Chemical Substances

2',6' - Pipecoloxylidide, 1 - methyl -

RTECS #: TK6300000

CAS #: 96-88-8

UPDATE: August 2007 MW: 246.39 MF: C₁₅H₂₂N₂O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

(+ - ) - 1 - Methyl - 2',6' - pipecoloxylidide

2 - Piperidinecarboxamide, N - (2,6 - dimethylphenyl) - methyl - (9CI)

Carbocaine

DL - Mepivacaine

Mepivacaine

N - Methylhexahydro - 2 - picolinic acid, 2,6 - dimethylanilide

N - Methyl - 2 - pipecolic acid, 2,6 - dimethylanilide

N - Methyl - 2 - pipecolic acid, 2,6 - xylidide

Scandicain

Scandicaine

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
rat lowest published toxic dose: 6 mg/kg (11 day pregnant) Reproductive: Effects on newborn: Behavioral NTOTDY 8,61,1986

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intradermal
human lowest published toxic dose: 5.63 mg/kg Peripheral Nerve and Sensation: Local anesthetic

Behavioral: Analgesia AANEAB 45,967,2001
intraperitoneal
mouse lowest published lethal dose: 135 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor TOIZAG 9,38,1962
intravenous
mouse lethal dose (50 percent kill): 35 mg/kg N/R APTOA6 31,273,1972
intravenous
rat lethal dose (50 percent kill): 30 mg/kg N/R ARVPAX 9,503,1969
intravenous
rabbit lowest published lethal dose: 53 mg/kg N/R APTOA6 31,273,1972
oral
mouse lethal dose (50 percent kill): >5 gm/kg N/R NIIRDN 6,845,1982
oral
mouse lowest published toxic dose: 100 mg/kg Gastrointestinal: Decreased motility or constipation ETPAEK 57,59,2005
oral
rat lethal dose (50 percent kill): >5 gm/kg N/R NIIRDN 6,845,1982
subcutaneous
mouse lethal dose (50 percent kill): 270 mg/kg N/R AANEAB 9,1,1965
subcutaneous
rat lethal dose (50 percent kill): 500 mg/kg N/R APTOA6 31,273,1972

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
BNYMAM 52,222,1976
TOXICOLOGY REVIEW
AINCM* 5,132,2004
TOXICOLOGY REVIEW
BPCRA* 17,471,2003

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5788;
Number of Industries 1;
Total Number of Facilities 13;
Number of Occupations 2;
Total Number of Employees Exposed 545;
Total Number of Female Employees Exposed 479

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN
REFERENCE

AANEAB Acta Anaesthesiologica Scandinavica. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1957-
AINCM* Anaesthesia and Intensive Care Medicine (Abingdon: Medicine Pub. Co.) V.1- 2000-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI.
BNYMAM Bulletin of the New York Academy of Medicine. (New York Academy of Medicine, 2 E. 103rd St., New York, NY 10029) Ser 2: V.1- 1925-
BPCRA* Best Practice & Research Clinical Anaesthesiology(Elsevier Ltd.) V.13- 1999-
ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena, Postfach 100537, D-07705 Jena, Germany) V.44- 1992-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC.
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954-

RTECS Compound Description:
   Drug
   Reproductive Effector
   Human Data

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SYNONYMS:
(+ - ) - 1 - Methyl - 2',6' - pipecoloxylidide 2 - Piperidinecarboxamide, N - (2,6 - dimethylphenyl) - methyl - (9CI) Carbocaine DL - Mepivacaine Mepivacaine	N - Methylhexahydro - 2 - picolinic acid, 2,6 - dimethylanilide N - Methyl - 2 - pipecolic acid, 2,6 - dimethylanilide N - Methyl - 2 - pipecolic acid, 2,6 - xylidide Scandicain Scandicaine

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intramuscular rat	lowest published toxic dose: 6 mg/kg (11 day pregnant)	Reproductive: Effects on newborn: Behavioral	NTOTDY 8,61,1986

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intradermal human	lowest published toxic dose: 5.63 mg/kg	Peripheral Nerve and Sensation: Local anesthetic Behavioral: Analgesia	AANEAB 45,967,2001
intraperitoneal mouse	lowest published lethal dose: 135 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Tremor	TOIZAG 9,38,1962
intravenous mouse	lethal dose (50 percent kill): 35 mg/kg	N/R	APTOA6 31,273,1972
intravenous rat	lethal dose (50 percent kill): 30 mg/kg	N/R	ARVPAX 9,503,1969
intravenous rabbit	lowest published lethal dose: 53 mg/kg	N/R	APTOA6 31,273,1972
oral mouse	lethal dose (50 percent kill): >5 gm/kg	N/R	NIIRDN 6,845,1982
oral mouse	lowest published toxic dose: 100 mg/kg	Gastrointestinal: Decreased motility or constipation	ETPAEK 57,59,2005
oral rat	lethal dose (50 percent kill): >5 gm/kg	N/R	NIIRDN 6,845,1982
subcutaneous mouse	lethal dose (50 percent kill): 270 mg/kg	N/R	AANEAB 9,1,1965
subcutaneous rat	lethal dose (50 percent kill): 500 mg/kg	N/R	APTOA6 31,273,1972

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		BNYMAM 52,222,1976
TOXICOLOGY REVIEW		AINCM* 5,132,2004
TOXICOLOGY REVIEW		BPCRA* 17,471,2003

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X5788; Number of Industries 1; Total Number of Facilities 13; Number of Occupations 2; Total Number of Employees Exposed 545; Total Number of Female Employees Exposed 479

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN	REFERENCE
AANEAB	Acta Anaesthesiologica Scandinavica. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1957-
AINCM*	Anaesthesia and Intensive Care Medicine (Abingdon: Medicine Pub. Co.) V.1- 2000-
APTOA6	Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARVPAX	Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI.
BNYMAM	Bulletin of the New York Academy of Medicine. (New York Academy of Medicine, 2 E. 103rd St., New York, NY 10029) Ser 2: V.1- 1925-
BPCRA*	Best Practice & Research Clinical Anaesthesiology(Elsevier Ltd.) V.13- 1999-
ETPAEK	Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena, Postfach 100537, D-07705 Jena, Germany) V.44- 1992-
NIIRDN	Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
NTOTDY	Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC.
TOIZAG	Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954-