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Phthalic acid, di (methoxyethyl) ester

RTECS #: TI1400000

CAS #: 117-82-8

UPDATE: May 2008 MW: 282.32 MF: C14H18O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,2 - Benzenedicarboxylic acid, bis (2 - methoxyethyl) ester (9CI)
  2. 2 - Methoxyethyl phthalate
  3. Bis (2 - methoxyethyl) phthalate
  4. Bis (methoxyethyl) phthalate
  5. DMEP
  1. Di (2 - methoxyethyl) phthalate
  2. Di - (2 - methoxyethyl) ester kyseliny ftalove (Czech)
  3. Dimethoxy ethyl phthalate
  4. Kesscoflex MCP
  5. Phthalic acid, bis (2 - methoxyethyl) ester


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg mild KODAK* #902511
skin
guinea pig 		500 mg mild KODAK* #902511


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
dominant lethal test intraperitoneal
mouse 		1,190 mg/kg TXAPA9 29,35,1974
sperm morphology oral
rat 		1,500 mg/kg ARTODN 53,71,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 2,380 mg/kg (1 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetal death 		EVHPAZ 3,81,1973
intraperitoneal
mouse 		lowest published toxic dose: 2,380 µg/kg (1 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) TXAPA9 29,35,1974
intraperitoneal
rat 		lowest published toxic dose: 500 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system 		TJADAB 29(2),54A,1984
intraperitoneal
rat 		lowest published toxic dose: 374 mg/kg (5-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		JPMSAE 61,51,1972
intraperitoneal
rat 		lowest published toxic dose: 374 mg/kg (5-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system JPMSAE 61,51,1972
intraperitoneal
rat 		lowest published toxic dose: 747 mg/kg (5-15 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Other developmental abnormalities 		JPMSAE 61,51,1972
intraperitoneal
rat 		lowest published toxic dose: 600 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		EVHPAZ 45,89,1982
oral
rat 		lowest published toxic dose: 1,500 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		TJADAB 26(3),14A,1982
oral
rat 		lowest published toxic dose: 593 mg/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system 		TJADAB 33,93C,1986
oral
rat 		lowest published toxic dose: 593 mg/kg (13 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system 		TJADAB 33,93C,1986
oral
rat 		lowest published toxic dose: 6 gm/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		NTIS** OTS0530376


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 1,595 ppm/6 hour Olfaction: Other olfaction effects 14CYAT 2,1905,1963
intraperitoneal
mouse 		lethal dose (50 percent kill): 2,510 mg/kg N/R 34ZIAG -,691,1969
intraperitoneal
rat 		lethal dose (50 percent kill): 3,736 µL/kg N/R JPMSAE 61,51,1972
oral
mouse 		lethal dose (50 percent kill): 3,200 mg/kg N/R 14CYAT 2,1904,1963
oral
rat 		lowest published lethal dose: 2,750 mg/kg N/R 29ZWAE -,356,1968
skin
guinea pig 		lethal dose (50 percent kill): >20 gm/kg N/R EPASR* 8EHQ-0391-1170


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 10,500 mg/kg/6 week- intermittent Related to Chronic Data: Changes in testicular weight JPMSAE 55,158,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
RREVAH 54,1,1975
TOXICOLOGY REVIEW
EVHPAZ 4,3,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - SWEDEN time-weighted average 3 mg/m3;
short term exposure limit 5 mg/m3, JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81810;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 5;
Total Number of Employees Exposed 1,029
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81810;
Number of Industries 1;
Total Number of Facilities 23;
Number of Occupations 1;
Total Number of Employees Exposed 68


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as plasticizer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63
29ZWAE "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH, Chemical Rubber Co., 1968
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as plasticizer

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Primary Irritant

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