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Phthalic acid, diisodecyl ester

RTECS #: TI1270000

CAS #: 26761-40-0

UPDATE: November 2008 MW: 446.74 MF: C28H46O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,2 - Benzenedicarboxylic acid, diisodecyl ester (9CI)
  2. Bis (isodecyl) phthalate
  3. DIDP (plasticizer)
  4. Diisodecyl phthalate
  1. Palatinol Z
  2. Sicol 184
  3. Vestinol DZ


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 10 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		FCTOD7 35,501,1997


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration : >130 mg/m3/6 hour N/R EXXON*
inhalation
mouse 		lethal concentration : >130 mg/m3/6 hour N/R EXXON*
inhalation
rat 		lethal concentration : >130 mg/m3/6 hour N/R EXXON*
oral
rat 		lethal dose (50 percent kill): 64 gm/kg N/R EVHPAZ 3,131,1973
oral
rabbit 		lowest published lethal dose: 22,500 µL/kg N/R EVHPAZ 3,61,1973
skin
rabbit 		lethal dose (50 percent kill): >3,160 mg/kg N/R EXXON*


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 58,800 mg/kg/14 week- continuous Liver: Changes in liver weight EVHPAZ 3,131,1973
oral
rat 		lowest published toxic dose: 1,680 mg/kg/28 day- continuous Liver: Other changes

Liver: Changes in liver weight 		NTIS** OTS0530400
oral
rat 		lowest published toxic dose: 14,000 mg/kg/4 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TERP2* -,310,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
TXAPA9 197,178,2004
TOXICOLOGY REVIEW
CRTXB2 36,695,2006
TOXICOLOGY REVIEW
REPTED 22,291,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 3 mg/m3, OCT 2002
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit - SWEDEN time-weighted average 3 mg/m3;
short term exposure limit 5 mg/m3, JUN2005
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3, 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83278;
Number of Industries 18;
Total Number of Facilities 1,017;
Number of Occupations 41;
Total Number of Employees Exposed 21,856
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83278;
Number of Industries 53;
Total Number of Facilities 2,962;
Number of Occupations 57;
Total Number of Employees Exposed 80,441;
Total Number of Female Employees Exposed 31,734


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TERP2*
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

NIOSH PROFILE (PHTHALATES), SRI, 2/77

NIOSH PROFILE (PHTHALATES), SRC, 3/82

RTECS Compound Description:
   Reproductive Effector

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