CDC logo, Safer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us




Phthalic acid, dihexyl ester

RTECS #: TI1100000

CAS #: 84-75-3

UPDATE: February 2008 MW: 334.50 MF: C20H30O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,2 - Benzenedicarboxylic acid, dihexyl ester
  2. Bis (n - hexyl) phthalate
  3. Di - n - hexyl phthalate
  1. Di - n - hexylphthalate
  2. Dihexyl phthalate
  3. Dihexylester kyseliny ftalove (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour mild 85JCAE -,388,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 13 gm/kg (7 day male/7 day prior to copulation-22 day pregnant) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		TXAPA9 88,255,1987
oral
mouse 		lowest published toxic dose: 7,920 mg/kg (6-13 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) TCMUD8 7,29,1987
oral
mouse 		lowest published toxic dose: 181 gm/kg (18 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		NTIS** PB85-249332
oral
mouse 		lowest published toxic dose: 30 gm/kg (7 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) 		TXAPA9 88,255,1987
oral
mouse 		lowest published toxic dose: 30 gm/kg (7 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) TXAPA9 88,255,1987
oral
mouse 		lowest published toxic dose: 13.3 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		NTIS** #PB85249332
oral
mouse 		lowest published toxic dose: 245.49 gm/kg (21 week male) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) 		NTIS** #PB85249332
oral
mouse 		lowest published toxic dose: 245.49 gm/kg (21 week prior to copulation) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) 		NTIS** #PB85249332
oral
mouse 		lowest published toxic dose: 79.2 gm/kg (6-13 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) REPTED 16,709,2002
oral
mouse 		lowest published toxic dose: 2,660 mg/kg (7 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) REPTED 16,709,2002
oral
mouse 		lowest published toxic dose: 10.64 gm/kg (7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) REPTED 16,709,2002
oral
mouse 		lowest published toxic dose: 13.3 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) 		REPTED 16,709,2002
oral
mouse 		lowest published toxic dose: 192 gm/kg (115 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) 		REPTED 16,709,2002
oral
mouse 		lowest published toxic dose: 192 gm/kg (115 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct REPTED 16,709,2002
oral
mouse 		lowest published toxic dose: 192 gm/kg (115 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility REPTED 16,709,2002
oral
rat 		lowest published toxic dose: 9,600 mg/kg (4 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct EVHPAZ 45,77,1982


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): 29,600 mg/kg N/R AMIHBC 10,61,1954
skin
rabbit 		lethal dose (50 percent kill): >20 mL/kg N/R AMIHBC 10,61,1954
unreported route
guinea pig 		lethal dose (50 percent kill): 12,130 mg/kg N/R GISAAA 55(9),26,1990
unreported route
mouse 		lethal dose (50 percent kill): 22,500 mg/kg N/R GISAAA 55(9),26,1990
unreported route
rat 		lethal dose (50 percent kill): >33 gm/kg N/R GISAAA 55(9),26,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
domestic bird 		lowest published toxic dose: 3,862 mg/kg/30 day- continuous Behavioral: Food intake (animal)

Biochemical: Metabolism (intermediary): Lipids including transport 		BECTA6 25,345,1980
oral
mouse 		lowest published toxic dose: 245.49 gm/kg/21 week- continuous Liver: Changes in liver weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** #PB85249332
oral
mouse 		lowest published toxic dose: 245.49 gm/kg/21 week- continuous Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		NTIS** #PB85249332
oral
mouse 		lowest published toxic dose: 245.49 gm/kg/21 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** #PB85249332
oral
mouse 		lowest published toxic dose: 192 gm/kg/115 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		REPTED 16,709,2002
oral
non-mammalian species 		lowest published toxic dose: 40 mg/kg/8 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AQUTO* 74,160,2005
oral
rat 		lowest published toxic dose: 25,200 mg/kg/21 day- continuous Liver: Fatty liver degeneration

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		TXAPA9 77,116,1985
oral
rat 		lowest published toxic dose: 3 gm/kg/30 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases 		GISAAA 55(9),26,1990
oral
rat 		lowest published toxic dose: 8,400 mg/kg/14 day- continuous Liver: Fatty liver degeneration

Endocrine: Evidence of thyroid hyperfunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		TOLED5 121,35,2001
oral
rat 		lowest published toxic dose: 28,000 mg/kg/10 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		ATSUDG 4,452,1980
oral
rat 		lowest published toxic dose: 42,000 mg/kg/21 day- continuous Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration

Liver: Changes in liver weight 		EVHPAZ 70,195,1986
oral
rat 		lowest published toxic dose: 3,600 mg/kg/3 day- continuous Endocrine: Evidence of thyroid hypofunction

Blood: Other changes 		EVHPAZ 70,195,1986
oral
rat 		lowest published toxic dose: 38,304 mg/kg /21 day- continuous Liver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		REPTED 16,709,2002
oral
rat 		lowest published toxic dose: 5,472 mg/kg /3 day- continuous Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes 		REPTED 16,709,2002
oral
rat 		lowest published toxic dose: 18,240 mg/kg /10 day- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		REPTED 16,709,2002
oral
rat 		lowest published toxic dose: 38,304 mg/kg /21 day- continuous Endocrine: Evidence of thyroid hyperfunction REPTED 16,709,2002
oral
rat 		lowest published toxic dose: 9.6 gm/kg/4 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight 		REPTED 16,709,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
EVHPAZ 3,73,1973
TOXICOLOGY REVIEW
RREVAH 54,1,1975
TOXICOLOGY REVIEW
FAATDF 13,747,1989
TOXICOLOGY REVIEW
CRTXB2 36,695,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83441;
Number of Industries 4;
Total Number of Facilities 89;
Number of Occupations 7;
Total Number of Employees Exposed 1,926
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83441;
Number of Industries 7;
Total Number of Facilities 431;
Number of Occupations 12;
Total Number of Employees Exposed 7,149;
Total Number of Female Employees Exposed 1,974


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
AQUTO* Aquatic Toxicology (Amsterdam, Netherlands : Elsevier/North Holland Biomedical Press) V.1 1981-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us