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Phthalanilic acid, 4' - (2 - thiazolylsulfamoyl) -

RTECS #: TH8575000

CAS #: 85-73-4

UPDATE: February 2006 MW: 403.45 MF: C17H13N3O5S2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. (o - Carboxybenzoyl) - p - aminophenylsulfonamidothiazole
  2. 2 - (N (sup 4) - Phthalyaminobenzenesulfonamide) thiazole
  3. 2 - (N (sup 4) - Phthalyaminobenzenesulfonamido) thiazole
  4. 2 - (N (sup 4) - Phthalylsulfanilamido) thiazole
  5. 2 - (p - N - Phthalylsulfanilyl) aminothiazole
  6. 2 - (p - Phthalylaminobenzenesulfamido) thiazole
  7. 4' - (2 - Thiazolylsulfamoyl) phthalanilic acid
  8. 4' - (2 - Thiazolylsulfamyl) phthalanilic acid
  9. AFI - Ftalyl
  10. Cremothalidine
  11. Enteramida
  12. Entero - sulfina
  13. Entexidin
  14. Entexidina
  15. Ftalazol
  16. Ftalylsulfathiazol (Czech)
  17. Intestiazol
  18. Phthalazol
  1. Phthalazole
  2. Phthaloylsulfathiazole
  3. Phthalylnorsulfazole
  4. Phthalylsulfathiazole
  5. Phthalylsulfonazole
  6. Phthalylsulphathiazole
  7. Sulfacetil
  8. Sulfanilamide, N (sup 4) - (o - carboxybenzoyl) - N' - 2 - thiazolyl -
  9. Sulfaphthalazole
  10. Sulfathalidine
  11. Sulftalyl
  12. Taleudron
  13. Talidine
  14. Taloudron
  15. Thalazole
  16. Thalistanin
  17. Thalistatyl
  18. Ultratiazol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 920 mg/kg N/R JPETAB 81,116,1944
oral
mouse 		lethal dose : >10 gm/kg N/R JPETAB 81,116,1944
unreported route
rat 		lethal dose : >10 gm/kg N/R GISAAA 58(12),9,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 12,900 mg/kg/30 day- intermittent Gastrointestinal: Changes in structure or function of esophagus GISAAA 58(12),9,1993
oral
rat 		lowest published toxic dose: 161 mg/kg/5 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Conditioned vitamin deficiency 		EKFAE9 61(6),48,1998
oral
rat 		lowest published toxic dose: 2,580 mg/kg/30 day- intermittent Blood: Changes in leukocyte (WBC) count

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		GISAAA 12,9,1993
oral
rat 		lowest published toxic dose: 870 mg/kg/30 day- intermittent Endocrine: Changes in spleen weight GISAAA 12,9,1993
oral
rat 		lowest published toxic dose: 12.9 gm/kg/30 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		GISAAA 12,9,1993
oral
rat 		lowest published toxic dose: 170.8 mg/kg/7 day- intermittent Biochemical: Effect on specific coenzyme: B vitamins including folate EKFAE9 62,48,1999


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84641;
Number of Industries 2;
Total Number of Facilities 193;
Number of Occupations 6;
Total Number of Employees Exposed 9,471
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84641;
Number of Industries 1;
Total Number of Facilities 16;
Number of Occupations 1;
Total Number of Employees Exposed 94;
Total Number of Female Employees Exposed 62


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-

RTECS Compound Description:
   Drug

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