RTECS:TH3495000 The Registry of Toxic Effects of Chemical Substances

Phosphorus (red)

RTECS #: TH3495000

CAS #: 7723-14-0

UPDATE: February 2009 MW: 30.97 MF: P

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Phosphorus

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mouse lowest published lethal concentration: 150 mg/m³ Cardiac: EKG changes not diagnostic of above

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes VCVN5* -,58,1993
inhalation
rat lowest published lethal concentration: 150 mg/m³ Cardiac: EKG changes not diagnostic of above

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes VCVN5* -,58,1993
inhalation
rabbit lowest published lethal concentration: 150 mg/m³ Cardiac: EKG changes not diagnostic of above

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes VCVN5* -,58,1993
oral
cat lethal dose (50 percent kill): 5 mg/kg N/R VCVN5* -,58,1993
oral
dog lethal dose (50 percent kill): 5 mg/kg N/R VCVN5* -,58,1993
oral
mouse lethal dose (50 percent kill): 11.5 mg/kg N/R VCVN5* -,58,1993
oral
rat lethal dose (50 percent kill): 11.5 mg/kg N/R VCVN5* -,58,1993
oral
rabbit lethal dose (50 percent kill): 105 mg/kg N/R VCVN5* -,58,1993
unreported route
man lowest published lethal dose: 4,412 痢/kg N/R 85DCAI 2,73,1970

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 5 mg/kg/10 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,58,1989
oral
rat lowest published toxic dose: 0.12 mg/kg/30 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain VCVN5* -,58,1989
oral
rat lowest published toxic dose: 5 mg/kg/5 day- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Fatty liver degeneration

Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) VCVN5* -,58,1989
oral
rat lowest published toxic dose: 0.9 mg/kg/26 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes VCVN5* -,59,1989
oral
rat lowest published toxic dose: 0.9 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning VCVN5* -,59,1989

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
ENTOX* -,624,2005

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 mg/m³, JAN1993
Occupational Exposure Limit - FINLAND short term exposure limit 0.1 mg/m³, Skin, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg/m³, short term exposure limit 0.1 mg/m³, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg/m³, APR2007
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg/m³, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg/m³, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg/m³, MAC(short term exposure limit) 0.24 mg/m³, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.03 mg/m³, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 mg/m³,KZG- week 0.1 mg/m³, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.1 mg/m³, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.1 mg/m³, JAN1993

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0004;
Number of Industries 2;
Total Number of Facilities 38;
Number of Occupations 3;
Total Number of Employees Exposed 205
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0005;
Number of Industries 1;
Total Number of Facilities 41;
Number of Occupations 5;
Total Number of Employees Exposed 626
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81650;
Number of Industries 19;
Total Number of Facilities 1,187;
Number of Occupations 42;
Total Number of Employees Exposed 13,630
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81684;
Number of Industries 3;
Total Number of Facilities 47;
Number of Occupations 4;
Total Number of Employees Exposed 261
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0004;
Number of Industries 1;
Total Number of Facilities 75;
Number of Occupations 1;
Total Number of Employees Exposed 675;
Total Number of Female Employees Exposed 225
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0005;
Number of Industries 1;
Total Number of Facilities 6;
Number of Occupations 1;
Total Number of Employees Exposed 91;
Total Number of Female Employees Exposed 6
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81650;
Number of Industries 104;
Total Number of Facilities 12,775;
Number of Occupations 88;
Total Number of Employees Exposed 208,975;
Total Number of Female Employees Exposed 7,598
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81684;
Number of Industries 5;
Total Number of Facilities 139;
Number of Occupations 10;
Total Number of Employees Exposed 2,924;
Total Number of Female Employees Exposed 67

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9187
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Phosphorus, 7905

REFERENCES:
CODEN
REFERENCE

85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

RTECS Compound Description:
Agricultural Chemical
Human Data

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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation mouse	lowest published lethal concentration: 150 mg/m³	Cardiac: EKG changes not diagnostic of above Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Other changes	VCVN5* -,58,1993
inhalation rat	lowest published lethal concentration: 150 mg/m³	Cardiac: EKG changes not diagnostic of above Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Other changes	VCVN5* -,58,1993
inhalation rabbit	lowest published lethal concentration: 150 mg/m³	Cardiac: EKG changes not diagnostic of above Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Other changes	VCVN5* -,58,1993
oral cat	lethal dose (50 percent kill): 5 mg/kg	N/R	VCVN5* -,58,1993
oral dog	lethal dose (50 percent kill): 5 mg/kg	N/R	VCVN5* -,58,1993
oral mouse	lethal dose (50 percent kill): 11.5 mg/kg	N/R	VCVN5* -,58,1993
oral rat	lethal dose (50 percent kill): 11.5 mg/kg	N/R	VCVN5* -,58,1993
oral rabbit	lethal dose (50 percent kill): 105 mg/kg	N/R	VCVN5* -,58,1993
unreported route man	lowest published lethal dose: 4,412 痢/kg	N/R	85DCAI 2,73,1970

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 5 mg/kg/10 day- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVN5* -,58,1989
oral rat	lowest published toxic dose: 0.12 mg/kg/30 day- intermittent	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVN5* -,58,1989
oral rat	lowest published toxic dose: 5 mg/kg/5 day- intermittent	Liver: Hepatitis (hepatocellular necrosis), diffuse Liver: Fatty liver degeneration Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)	VCVN5* -,58,1989
oral rat	lowest published toxic dose: 0.9 mg/kg/26 week- intermittent	Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes	VCVN5* -,59,1989
oral rat	lowest published toxic dose: 0.9 mg/kg/26 week- intermittent	Behavioral: Alteration of classical conditioning	VCVN5* -,59,1989

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		ENTOX* -,624,2005

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988	PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION	FEREAC 54,7740,1989
Occupational Exposure Limit - ARAB Republic of Egypt	time-weighted average 0.1 mg/m³, JAN1993
Occupational Exposure Limit - FINLAND	short term exposure limit 0.1 mg/m³, Skin, JAN1999
Occupational Exposure Limit - HUNGARY	time-weighted average 0.1 mg/m³, short term exposure limit 0.1 mg/m³, SEP2000
Occupational Exposure Limit - JAPAN	Occupational Exposure Limit 0.1 mg/m³, APR2007
Occupational Exposure Limit - NORWAY	time-weighted average 0.1 mg/m³, JAN1999
Occupational Exposure Limit - THE PHILIPPINES	time-weighted average 0.1 mg/m³, JAN1993
Occupational Exposure Limit - POLAND	MAC(time-weighted average) 0.3 mg/m³, MAC(short term exposure limit) 0.24 mg/m³, JAN1999
Occupational Exposure Limit - RUSSIA	short term exposure limit 0.03 mg/m³, JUN2003
Occupational Exposure Limit - SWITZERLAND	MAK- week 0.05 mg/m³,KZG- week 0.1 mg/m³, DEC2006
Occupational Exposure Limit - THAILAND	time-weighted average 0.1 mg/m³, JAN1993
Occupational Exposure Limit - TURKEY	time-weighted average 0.1 mg/m³, JAN1993

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: M0004; Number of Industries 2; Total Number of Facilities 38; Number of Occupations 3; Total Number of Employees Exposed 205
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: M0005; Number of Industries 1; Total Number of Facilities 41; Number of Occupations 5; Total Number of Employees Exposed 626
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 81650; Number of Industries 19; Total Number of Facilities 1,187; Number of Occupations 42; Total Number of Employees Exposed 13,630
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 81684; Number of Industries 3; Total Number of Facilities 47; Number of Occupations 4; Total Number of Employees Exposed 261
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: M0004; Number of Industries 1; Total Number of Facilities 75; Number of Occupations 1; Total Number of Employees Exposed 675; Total Number of Female Employees Exposed 225
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: M0005; Number of Industries 1; Total Number of Facilities 6; Number of Occupations 1; Total Number of Employees Exposed 91; Total Number of Female Employees Exposed 6
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 81650; Number of Industries 104; Total Number of Facilities 12,775; Number of Occupations 88; Total Number of Employees Exposed 208,975; Total Number of Female Employees Exposed 7,598
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 81684; Number of Industries 5; Total Number of Facilities 139; Number of Occupations 10; Total Number of Employees Exposed 2,924; Total Number of Female Employees Exposed 67

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9187
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Phosphorus, 7905

REFERENCES:
CODEN	REFERENCE
85DCAI	"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
ENTOX*	Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FEREAC	Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
VCVN5*	"Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.