RTECS:TC6125000 The Registry of Toxic Effects of Chemical Substances

Phosphoric acid, 2 - ethylhexyl diphenyl ester

RTECS #: TC6125000

CAS #: 1241-94-7

UPDATE: February 2006 MW: 362.44 MF: C₂₀H₂₇O₄P

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

(2 - Ethylhexyl) - difenylfosfat (Czech)

1 - Hexanol, 2 - ethyl - , ester with diphenyl phosphate

2 - Ethylhexyl diphenylphosphate

Diphenyl 2 - ethylhexyl phosphate

Santicizer 141

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 54 gm/kg (10 week male/3 week prior to copulation-22 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS OTS0538371

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE**
intraperitoneal
mouse lethal dose (50 percent kill): 930 mg/kg Behavioral: Anticonvulsant

Behavioral: Tremor

Behavioral: Muscle weakness TSCAT* OTS 206227
intravenous
rabbit lowest published lethal dose: 272 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory stimulation AMIHBC 8,170,1953
oral
chicken lethal dose (50 percent kill): >10 gm/kg N/R TXAPA9 41,291,1977
oral
rat lowest published lethal dose: 7,500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS OTS0545845
oral
rabbit lethal dose (50 percent kill): 218 mg/kg N/R IPSTB3 3,93,1976
skin
rabbit lethal dose (50 percent kill): >7,900 mg/kg N/R TXAPA9 41,291,1977

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 437 gm/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain AMIHBC 8,170,1953
oral
rat lowest published toxic dose: 43,200 mg/kg/90 day- continuous Liver: Changes in liver weight

Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS OTS0540107

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m³, Skin, JUN2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84203;
Number of Industries 20;
Total Number of Facilities 587;
Number of Occupations 16;
Total Number of Employees Exposed 11,432
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84203;
Number of Industries 33;
Total Number of Facilities 1,223;
Number of Occupations 28;
Total Number of Employees Exposed 21,161;
Total Number of Female Employees Exposed 4,366

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as fire-resistant plasticizer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0193-8695;8EHQ-0892-9290
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as fire-resistant plasticizer

NIOSH PROFILE (ARYL PHOSPHATES), SRC, 12/79

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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 54 gm/kg (10 week male/3 week prior to copulation-22 day pregnant)	Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	NTIS** OTS0538371

SYNONYMS:
(2 - Ethylhexyl) - difenylfosfat (Czech) 1 - Hexanol, 2 - ethyl - , ester with diphenyl phosphate 2 - Ethylhexyl diphenylphosphate	Diphenyl 2 - ethylhexyl phosphate Santicizer 141

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 930 mg/kg	Behavioral: Anticonvulsant Behavioral: Tremor Behavioral: Muscle weakness	TSCAT* OTS 206227
intravenous rabbit	lowest published lethal dose: 272 mg/kg	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Respiratory stimulation	AMIHBC 8,170,1953
oral chicken	lethal dose (50 percent kill): >10 gm/kg	N/R	TXAPA9 41,291,1977
oral rat	lowest published lethal dose: 7,500 mg/kg	Behavioral: Convulsions or effect on seizure threshold Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0545845
oral rabbit	lethal dose (50 percent kill): 218 mg/kg	N/R	IPSTB3 3,93,1976
skin rabbit	lethal dose (50 percent kill): >7,900 mg/kg	N/R	TXAPA9 41,291,1977

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 437 gm/kg/2 year- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AMIHBC 8,170,1953
oral rat	lowest published toxic dose: 43,200 mg/kg/90 day- continuous	Liver: Changes in liver weight Endocrine: Changes in adrenal weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0540107

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Occupational Exposure Limit - RUSSIA	short term exposure limit 0.5 mg/m³, Skin, JUN2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 84203; Number of Industries 20; Total Number of Facilities 587; Number of Occupations 16; Total Number of Employees Exposed 11,432
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 84203; Number of Industries 33; Total Number of Facilities 1,223; Number of Occupations 28; Total Number of Employees Exposed 21,161; Total Number of Female Employees Exposed 4,366

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE	FEREAC 47,26992,82
Used as fire-resistant plasticizer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0193-8695;8EHQ-0892-9290
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
AMIHBC	AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
FEREAC	Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IPSTB3	International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TSCAT*	Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-