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Phosphoric acid, 2 - chloro - 1 - (2,4,5 - trichlorophenyl) vinyl dimethyl ester, (Z) -

RTECS #: TB9100000

CAS #: 22248-79-9

UPDATE: February 2009 MW: 365.96 MF: C10H9Cl4O4P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. REFERENCES:

SYNONYMS:

  1. (Z) - 2 - Chloro - 1 - (2,4,5 - trichlorophenyl) vinyl dimethyl phosphate
  2. 2,4,5 - Trichloro - alpha - (chloromethylene) benzyl phosphate ester
  3. Appex
  4. CVMP
  5. Debantic
  6. Dietreen
  7. Dust M
  8. ENT 25,841
  9. Gardcide
  10. Gardona
  11. OMS - 595
  1. Phosphoric acid, 2 - chloro - 1 - (2,4,5 - trichlorophenyl) ethenyl dimethyl ester, (Z) -
  2. ROL
  3. Rabon
  4. Rabond
  5. SD 8447
  6. Shell SD 8447
  7. Stirofos
  8. Stirophos
  9. Tetrachlorvinphos
  10. Vinfos
  11. cis - Gardona


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis mouse other cell types 500 µg/L MUREAV 279,165,1992
micronucleus test intraperitoneal
mouse 		200 mg/kg/7 day- intermittent MUREAV 117,329,1983
micronucleus test oral
mouse 		720 mg/kg/24 hour- continuous MUREAV 117,329,1983
sister chromatid exchange mouse other cell types 500 µg/L MUREAV 279,165,1992


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 1,384 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors 		FAATDF 5,840,1985


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lethal concentration : >290 mg/m3/4 hour N/R GTPZAB 19(4),50,1975
inhalation
guinea pig 		lethal concentration : >854 mg/m3 Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		GTPZAB 31(1),47,1987
inhalation
mouse 		lethal concentration : >290 mg/m3/4 hour N/R GTPZAB 19(4),50,1975
inhalation
rat 		lethal concentration : >854 mg/m3 Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		GTPZAB 31(1),47,1987
inhalation
rabbit 		lethal concentration : >290 mg/m3/4 hour N/R GTPZAB 19(4),50,1975
intraperitoneal
guinea pig 		lethal dose (50 percent kill): >5 gm/kg N/R PSSCBG 3,517,1972
oral
wild bird 		lethal dose (50 percent kill): 100 mg/kg N/R TXAPA9 21,315,1972
oral
chicken 		lethal dose (50 percent kill): 2,528 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		TXAPA9 11,49,1967
oral
cattle 		lethal dose (50 percent kill): 360 mg/kg N/R VETNAL 57(5),55,1981
oral
duck 		lethal dose (50 percent kill): >2 gm/kg N/R PEMNDP 9,802,1991
oral
guinea pig 		lethal dose (50 percent kill): 1,600 mg/kg N/R GTPZAB 31(1),47,1987
oral
mouse 		lethal dose (50 percent kill): 1,379 mg/kg N/R CHYCDW 21,65,1987
oral
rat 		lethal dose (50 percent kill): 480 mg/kg Behavioral: Somnolence (general depressed activity) PSSCBG 3,517,1972
subcutaneous
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R 28ZEAL 4,113,1969
skin
mouse 		lethal dose (50 percent kill): >7,500 mg/kg N/R YKYUA6 37,427,1986
skin
rat 		lethal dose (50 percent kill): 1,500 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase PSSCBG 3,517,1972
skin
rabbit 		lethal dose (50 percent kill): >2,500 mg/kg N/R JAFCAU 14,352,1966
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 4 gm/kg N/R 30ZDA9 -,315,1971
unreported route
rat 		lethal dose (50 percent kill): 7,473 mg/kg N/R GISAAA 51(4),32,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
horse, donkey 		lowest published toxic dose: 30.87 mg/kg/21 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 78,426,2004
oral
rat 		lowest published toxic dose: 4,550 mg/kg/26 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GNAMAP 17,33,1978
oral
rat 		lowest published toxic dose: 2,520 mg/kg/2 week- continuous Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JAFCAU 14,352,1966
oral
rat 		lowest published toxic dose: 280 mg/kg/28 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		ESKHA5 (108),45,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 30,197,1983
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 30,197,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
ENTOX* -,154,2005
TOXICOLOGY REVIEW
HETOEA 25,413,2006
TOXICOLOGY REVIEW
FEREAC 73,6867,2008
TOXICOLOGY REVIEW
FEREAC 73,6867,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,153,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1542;
Number of Industries 1;
Total Number of Facilities 31;
Number of Occupations 4;
Total Number of Employees Exposed 644;
Total Number of Female Employees Exposed 123


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
PSSCBG Pesticide Science. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1970-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as an insecticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

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