RTECS:TB6300000 The Registry of Toxic Effects of Chemical Substances

Phosphoric acid

RTECS #: TB6300000

CAS #: 7664-38-2

UPDATE: May 2009 MW: 98.00 MF: H₃O₄P

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Acide phosphorique (French)

Acido fosforico (Italian)

Fosforzuuroplossingen (Dutch)

Hydrogen phosphate

Orthophosphoric acid

Phosphoric acid (ACGIH:OSHA)

Phosphorsaeureloesungen (German)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mouse lethal concentration (50 percent kill): 25.5 mg/m³ Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Changes in liver weight VCVN5* -,73,1993
inhalation
rat lethal concentration (50 percent kill): 25.5 mg/m³ Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Changes in liver weight VCVN5* -,73,1993
oral
mouse lethal dose (50 percent kill): 1.25 gm/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Changes in liver weight VCVN5* -,73,1993
oral
rat lethal dose (50 percent kill): 1.25 gm/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Changes in liver weight VCVN5* -,73,1993
unreported route
man lowest published lethal dose: 220 mg/kg N/R 85DCAI 2,73,1970

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg/m³;short term exposure limit 3 mg/m³ DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
ARTODN 39,299,1978
TOXICOLOGY REVIEW
CHHSA* 11,35,2004

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,325,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 mg/m³ DTLVS* 3,210,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 mg/m³ CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 mg/m³ CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 mg/m³ CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 mg/m³ CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 1 mg/m³, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg/m³, short term exposure limit 3 mg/m³, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1 mg/m³, short term exposure limit 2 mg/m³, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1 mg/m³, OCT 2002
Occupational Exposure Limit - EC time-weighted average 1 mg/m³;
short term exposure limit 2 mg/m³, FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 1 mg/m³, short term exposure limit 3 mg/m³, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.2 ppm (1 mg/m³), VLE 0.5 ppm (2 mg/m³), FEB2006
Occupational Exposure Limit - GERMANY MAK 2 mg/m³ (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 1 mg/m³, short term exposure limit 2 mg/m³, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 1 mg/m³, APR2007
Occupational Exposure Limit - KOREA time-weighted average 1 mg/m³, short term exposure limit 3 mg/m³, 2006
Occupational Exposure Limit - MEXICO time-weighted average 1 mg/m³;
short term exposure limit 3 mg/m³, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m³, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 mg/m³, JAN2002
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m³, MAC(short term exposure limit) 3 mg/m³, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 1 mg/m³;
short term exposure limit 3 mg/m³, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 1 mg/m³,KZG- week 2 mg/m³, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 1 mg/m³, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 mg/m³;
short term exposure limit 2 mg/m³, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1 mg/m³;
short term exposure limit 3 mg/m³
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1 mg/m³;
short term exposure limit 3 mg/m³

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSPHORIC ACID-air 10 hour time-weighted average 1 mg/m³;
short term exposure limit 3 mg/m³ NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 58520;
Number of Industries 257;
Total Number of Facilities 42,406;
Number of Occupations 146;
Total Number of Employees Exposed 454,920
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 58520;
Number of Industries 309;
Total Number of Facilities 61,396;
Number of Occupations 198;
Total Number of Employees Exposed 1,256,907;
Total Number of Female Employees Exposed 450,478

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Acids, inorganic, 7903
OSHA ANALYTICAL METHOD #ID-111

REFERENCES:
CODEN
REFERENCE

85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHHSA* Chemical Health & Safety (Orlando, FL : Published by Elsevier Inc. for the ACS Division of Chemical Health and Safety) V.1- 1994-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Top 50 chemical production: 25.36 billions lbs in 1992, 24.11 billions in 1991

NIOSH PROFILE (FERTILIZER MANUFACTURE), SRC, 3/80

NIOSH PROFILE (PETROLEUM REFINING), FIRL, 4/78

FDA-over the counter and proprietary drug

RTECS Compound Description:
   Mutagen
   Human Data
   Primary Irritant

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SYNONYMS:
Acide phosphorique (French) Acido fosforico (Italian) Fosforzuuroplossingen (Dutch) Hydrogen phosphate	Orthophosphoric acid Phosphoric acid (ACGIH:OSHA) Phosphorsaeureloesungen (German)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation mouse	lethal concentration (50 percent kill): 25.5 mg/m³	Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Changes in liver weight	VCVN5* -,73,1993
inhalation rat	lethal concentration (50 percent kill): 25.5 mg/m³	Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Changes in liver weight	VCVN5* -,73,1993
oral mouse	lethal dose (50 percent kill): 1.25 gm/kg	Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Changes in liver weight	VCVN5* -,73,1993
oral rat	lethal dose (50 percent kill): 1.25 gm/kg	Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Changes in liver weight	VCVN5* -,73,1993
unreported route man	lowest published lethal dose: 220 mg/kg	N/R	85DCAI 2,73,1970

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	time-weighted average 1 mg/m³;short term exposure limit 3 mg/m³	DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW		ARTODN 39,299,1978
TOXICOLOGY REVIEW		CHHSA* 11,35,2004

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988	PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION	FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF	PESTICIDES: RED Completed	RBREV* -,325,1998
Mine Safety and Health Administration (MSHA) STANDARD - air	time-weighted average 1 mg/m³	DTLVS* 3,210,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8 hour time-weighted average 1 mg/m³	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8 hour time-weighted average 1 mg/m³	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8 hour time-weighted average 1 mg/m³	CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8 hour time-weighted average 1 mg/m³	CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt	time-weighted average 1 mg/m³, JAN1993
Occupational Exposure Limit - AUSTRALIA	time-weighted average 1 mg/m³, short term exposure limit 3 mg/m³, JUL2008
Occupational Exposure Limit - BELGIUM	time-weighted average 1 mg/m³, short term exposure limit 2 mg/m³, MAR2002
Occupational Exposure Limit - DENMARK	time-weighted average 1 mg/m³, OCT 2002
Occupational Exposure Limit - EC	time-weighted average 1 mg/m³; short term exposure limit 2 mg/m³, FEB 2006
Occupational Exposure Limit - FINLAND	time-weighted average 1 mg/m³, short term exposure limit 3 mg/m³, Skin, JAN1999
Occupational Exposure Limit - FRANCE	VME 0.2 ppm (1 mg/m³), VLE 0.5 ppm (2 mg/m³), FEB2006
Occupational Exposure Limit - GERMANY	MAK 2 mg/m³ (inhalable), 2005
Occupational Exposure Limit - HUNGARY	time-weighted average 1 mg/m³, short term exposure limit 2 mg/m³, SEP2000
Occupational Exposure Limit - JAPAN	Occupational Exposure Limit 1 mg/m³, APR2007
Occupational Exposure Limit - KOREA	time-weighted average 1 mg/m³, short term exposure limit 3 mg/m³, 2006
Occupational Exposure Limit - MEXICO	time-weighted average 1 mg/m³; short term exposure limit 3 mg/m³, 2004
Occupational Exposure Limit - THE NETHERLANDS	MAC-TGG 1 mg/m³, 2003
Occupational Exposure Limit - NEW ZEALAND	time-weighted average 1 mg/m³, JAN2002
Occupational Exposure Limit - POLAND	MAC(time-weighted average) 1 mg/m³, MAC(short term exposure limit) 3 mg/m³, JAN1999
Occupational Exposure Limit - SWEDEN	time-weighted average 1 mg/m³; short term exposure limit 3 mg/m³, JUN2005
Occupational Exposure Limit - SWITZERLAND	MAK- week 1 mg/m³,KZG- week 2 mg/m³, DEC2006
Occupational Exposure Limit - THAILAND	time-weighted average 1 mg/m³, JAN1993
Occupational Exposure Limit - UNITED KINGDOM	time-weighted average 1 mg/m³; short term exposure limit 2 mg/m³, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; time-weighted average 1 mg/m³; short term exposure limit 3 mg/m³
Occupational Exposure Limit IN SINGAPORE, VIETNAM	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg/m³; short term exposure limit 3 mg/m³

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSPHORIC ACID-air	10 hour time-weighted average 1 mg/m³; short term exposure limit 3 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 58520; Number of Industries 257; Total Number of Facilities 42,406; Number of Occupations 146; Total Number of Employees Exposed 454,920
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 58520; Number of Industries 309; Total Number of Facilities 61,396; Number of Occupations 198; Total Number of Employees Exposed 1,256,907; Total Number of Female Employees Exposed 450,478

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Acids, inorganic, 7903
OSHA ANALYTICAL METHOD #ID-111

REFERENCES:
CODEN	REFERENCE
85DCAI	"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
ARTODN	Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR	Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHHSA*	Chemical Health & Safety (Orlando, FL : Published by Elsevier Inc. for the ACS Division of Chemical Health and Safety) V.1- 1994-
DTLVS*	The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC	Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
NIOSH*	National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV*	Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
VCVN5*	"Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.