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Phosphonothioic acid, methyl - , S - (2 - (diisopropylamino) ethyl) O - ethyl ester

RTECS #: TB1090000

CAS #: 50782-69-9

UPDATE: May 2009 MW: 267.41 MF: C11H26NO2PS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. EA 1701
  2. Ethyl S - 2 - diisopropylaminoethyl methylphosphonothiolate
  3. Ethyl S - dimethylaminoethyl methylphosphonothiolate
  4. Ethyl - S - diisopropylaminoethyl methylthiophosphonate
  5. Methylphosphonothioic acid S - (2 - (bis (methylethyl) amino) ethyl) O - ethyl ester
  6. O - Ethyl - S - 2 - diisopropylaminoethylester kyseliny methylthiofosfonove (Czech)
  1. O - Ethyl S - 2 - diisopropylaminoethyl methylphosphonothiote
  2. Phosphonothioic acid, methyl - , S - (2 - (bis (1 - methylethyl) amino) ethyl) O - ethyl ester (9CI)
  3. S - (2 - Diisopropylaminoethyl) O - ethyl methyl phosphonothiolate
  4. TX60
  5. VX


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 75 µg/kg (6-20 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Behavioral 		TJADAB 36,25A,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration (50 percent kill): 27.03 mg/m3/4 minute Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 219,142,2007
inhalation
rat 		lowest published toxic concentration: 0.1 mg/m3/1 hour Brain and Coverings: Other degenerative changes

Eye: Miosis (pupilliary constriction) 		TOXID9 44,162,2005
inhalation
rat 		lowest published toxic concentration: 0.16 mg/m3/60 minute Eye: Miosis (pupilliary constriction)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TXCYAC 232,109,2007
inhalation
rat 		lowest published toxic concentration: 0.45 mg/m3/60 minute Behavioral: Tremor

Behavioral: Ataxia 		TXCYAC 232,109,2007
inhalation
rat 		lowest published toxic concentration: 0.3 mg/m3/60 minute Behavioral: Alteration of classical conditioning TXCYAC 232,109,2007
inhalation
rabbit 		lowest published lethal dose: 28 mg/kg/4 hour Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 60,126,2001
implant
rat 		lethal dose (50 percent kill): 45 µg/kg N/R TXAPA9 231,17,2008
intramuscular
chicken 		lethal dose (50 percent kill): 30 µg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases JTEHD6 23,103,1988
intramuscular
chicken 		lethal dose (50 percent kill): 30 mg/kg N/R ENTOX* -,457,2005
intramuscular
dog 		lethal dose (50 percent kill): 0.3 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JJATDK 26,439,2006
intramuscular
human 		lowest published toxic dose: 3,200 ng/kg Eye: Visual field changes

Behavioral: Sleep

Gastrointestinal: Nausea or vomiting 		85IVAW 1,E1,1982
intramuscular
human 		lethal dose (50 percent kill): 0.12 mg/kg N/R ENTOX* -,457,2005
intraperitoneal
mouse 		lethal dose (50 percent kill): 50 µg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Gastrointestinal: Other changes 		WHOTAC -,39,1970
intraperitoneal
mouse 		lethal dose (50 percent kill): 50 mg/kg N/R ENTOX* -,457,2005
intraperitoneal
rat 		lethal dose (50 percent kill): 37 µg/kg N/R JTEHF8 59,439,2000
intraperitoneal
rabbit 		lethal dose (50 percent kill): 66 µg/kg N/R ABMHAM (Suppl),226,1984
intravenous
cat 		lethal dose (50 percent kill): 5 µg/kg N/R NRTXDN 7,225,1986
intravenous
human 		lethal dose (50 percent kill): 0.8 mg/kg N/R ENTOX* -,457,2005
intravenous
man 		lowest published toxic dose: 1,500 ng/kg Behavioral: Hallucinations, distorted perceptions

Vascular: BP elevation not characterized in autonomic section

Gastrointestinal: Nausea or vomiting 		TXAPA9 27,241,1974
intravenous
man 		lowest published toxic dose: 225 ng/kg Behavioral: Headache

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JTEHF8 59,439,2000
intravenous
monkey 		lethal dose (50 percent kill): 6 µg/kg N/R JTEHF8 59,439,2000
intravenous
mouse 		lethal dose (50 percent kill): 0.12 mg/kg N/R ENTOX* ,706,2005
intravenous
pig 		lethal dose (50 percent kill): 11.8 µg/kg N/R TOXID9 -,26,2008
intravenous
pig 		lowest published toxic dose: 6 µg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXCYAC 248,151,2008
intravenous
rat 		lethal dose (50 percent kill): 7 µg/kg N/R JTEHF8 59,439,2000
oral
man 		lowest published toxic dose: 4 µg/kg Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting 		TXAPA9 27,241,1974
subcutaneous
guinea pig 		lethal dose (50 percent kill): 8,400 ng/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness 		TXAPA9 40,109,1977
subcutaneous
guinea pig 		lowest published lethal dose: 16 µg/kg Brain and Coverings: Changes in surface EEG

Brain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold 		TXAPA9 188,69,2003
subcutaneous
guinea pig 		lowest published toxic dose: 0.45 mg/kg Behavioral: Tremor

Nutritional and Gross Metabolic: Body temperature decrease 		NRTXDN 27,485,2006
subcutaneous
guinea pig 		lowest published lethal dose: 16 µg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		JPETAB 320,154,2007
subcutaneous
guinea pig 		lethal dose (50 percent kill): 8,400 mg/kg N/R ENTOX* -,457,2005
subcutaneous
human 		lowest published toxic dose: 30 µg/kg Behavioral: Headache

Gastrointestinal: Nausea or vomiting

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		85IVAW 1,E1,1982
subcutaneous
mouse 		lethal dose (50 percent kill): 10 µg/kg N/R JPETAB 299,528,2001
subcutaneous
rat 		lethal dose (50 percent kill): 12 µg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase AIPTAK 262,231,1983
subcutaneous
rat 		lowest published lethal dose: 24 µg/kg Brain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		ARTODN 76,650,2002
subcutaneous
rat 		lethal dose (50 percent kill): 12 mg/kg N/R ENTOX* -,457,2005
subcutaneous
rabbit 		lethal dose (50 percent kill): 14 µg/kg N/R ABMHAM (Suppl),226,1984
skin
guinea pig 		lethal dose (50 percent kill): 80 µg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		JAPTO* 25,410,2005
skin
human 		lowest published lethal dose: 86 µg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Gastrointestinal: Other changes 		WHOTAC -,24,1970
skin
human 		lethal dose (50 percent kill): 0.315 mg/kg N/R ENTOX* -,457,2005
skin
pig 		lowest published lethal dose: 120 µg/kg Eye: Miosis (pupilliary constriction)

Lung, Thorax, or Respiration: Respiratory depression

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HETOEA 22,255,2003
skin
rabbit 		lethal dose (50 percent kill): 250 µg/kg N/R NTIS** AD839-329
skin
rabbit 		lethal dose (50 percent kill): 0.35 mg/kg/24 hour N/R TOXID9 72,164,2003


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
rat 		lowest published toxic dose: 22.5 µg/kg/10 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 231,17,2008
implant
rat 		lowest published toxic dose: 810 µg/kg/30 day- intermittent Behavioral: Tremor

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 231,17,2008
implant
rat 		lowest published toxic dose: 204.75 µg/kg/91 day- intermittent Behavioral: Change in psychophysiological tests TXAPA9 231,17,2008
oral
domestic animal 		lowest published toxic dose: 3,360 ng/kg/56 day- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JTEHF8 59,439,2000
subcutaneous
rat 		lowest published toxic dose: 137 µg/kg/14 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JTEHF8 59,439,2000
subcutaneous
rat 		lowest published toxic dose: 360 µg/kg/90 day- intermittent Brain and Coverings: Changes in brain weight

Behavioral: Somnolence (general depressed activity)

Behavioral: Aggression 		JTEHF8 59,439,2000
subcutaneous
rat 		lowest published toxic dose: 70 µg/kg/2 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TXCYAC 250,32,2008
subcutaneous
rat 		lowest published toxic dose: 140 µg/kg/1 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TXCYAC 250,32,2008
subcutaneous
rat 		lowest published toxic dose: 210 µg/kg/1 week- continuous Behavioral: Tremor

Behavioral: Change in motor activity (specific assay)

Behavioral: Irritability 		TXCYAC 250,32,2008
subcutaneous
rat 		lowest published toxic dose: 280 µg/kg/1 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXCYAC 250,32,2008
subcutaneous
rat 		lowest published toxic dose: 5 µg/kg/2 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXCYAC 250,32,2008
subcutaneous
rat 		lowest published toxic dose: 80 µg/kg/4 week- continuous Endocrine: Other changes TXCYAC 250,32,2008


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
CCATAR 366,1,2006
TOXICOLOGY REVIEW
TXCYAC 214,221,2005
TOXICOLOGY REVIEW
EJPHAZ 553,10,2006
TOXICOLOGY REVIEW
ENTOX* -,457,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
85IVAW "Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents," National Research Council, 3 vols., Washington, DC, National Academy Press, 1982-85
ABMHAM Archives Belges de Medecine Sociale, Hygiene, Medecine du Trevail et Medecine Legale. (Quartier Esplanade no.6, 1010 Brussels, Belgium) V.4- 1946-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CCATAR Clinica Chimica Acta. (Elsevier Science B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1956-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
WHOTAC World Health Organization, Technical Report Series. (WHO, 1211 Geneva, 27, Switzerland) No.1- 1950-

Used as a chemical warfare agent

RTECS Compound Description:
   Drug
   Reproductive Effector
   Human Data

ALT CAS #: 51848-47-6
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