The Registry of Toxic Effects of Chemical Substances

Phosphonofluoridic acid, methyl - , isopropyl ester

RTECS #: TA8400000

CAS #: 107-44-8

UPDATE: February 2008 MW: 140.11 MF: C4H10FO2P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. EA 1208
  2. GB
  3. IMPF
  4. Isopropoxymethylphosphoryl fluoride
  5. Isopropyl methanefluorophosphonate
  6. Isopropyl methylfluorophosphate
  7. Isopropyl methylphosphonofluoridate
  8. Isopropyl - methyl - phosphoryl fluoride
  9. Isopropylester kyseliny methylfluorfosfonove (Czech)
  10. MFI
  11. Methylfluorphosphorsaeureisopropylester (German)
  12. Methylphosphonofluoridic acid 1 - methylethyl ester
  1. Methylphosphonofluoridic acid isopropyl ester
  2. O - Isopropyl methylphosphonofluoridate
  3. Phosphine oxide, fluoroisopropoxymethyl -
  4. Phosphoric acid, methylfluoro - , isopropyl ester
  5. Sarin
  6. Sarin II
  7. T - 144
  8. T - 2106
  9. TL 1618
  10. Trilone 46
  11. o - Isopropyl methylphosphonofluoridate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lethal concentration (50 percent kill): 124 mg/m3/2 minute N/R JAPTO* 25,393,2005
inhalation
cat 		lethal concentration (50 percent kill): 900 mg/m3/10 minute N/R JAPTO* 25,393,2005
inhalation
dog 		lethal concentration (50 percent kill): 176 mg/m3/2 minute N/R JAPTO* 25,393,2005
inhalation
dog 		lethal concentration (50 percent kill): 1,220 mg/m3/10 minute N/R JAPTO* 25,393,2005
inhalation
domestic animal 		lethal concentration (50 percent kill): 438 mg/m3/2 minute N/R JAPTO* 25,393,2005
inhalation
domestic animal 		lethal concentration (50 percent kill): 2,270 mg/m3/10 minute N/R JAPTO* 25,393,2005
inhalation
guinea pig 		lethal concentration (50 percent kill): 128 mg/m3/2 minute N/R 85JCAE -,1126,1986
inhalation
guinea pig 		lethal concentration (50 percent kill): 14,340 mg/m3/60 minute N/R TOXID9 44,161,2005
inhalation
guinea pig 		lowest published toxic concentration: 1,434 mg/m3/60 minute Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 44,161,2005
inhalation
guinea pig 		lowest published toxic concentration: 143.4 mg/m3/6 minute Eye: Miosis (pupilliary constriction) TOXID9 44,161,2005
inhalation
guinea pig 		lowest published toxic concentration: 7.1 µg/m3/273 minute Eye: Miosis (pupilliary constriction) JAPTO* 24,59,2004
inhalation
guinea pig 		lowest published toxic concentration: 7.4 µg/m3/270 minute Eye: Miosis (pupilliary constriction) JAPTO* 24,59,2004
inhalation
guinea pig 		lowest published toxic concentration: 15.5 µg/m3/67 minute Eye: Miosis (pupilliary constriction) JAPTO* 24,59,2004
inhalation
guinea pig 		lowest published toxic concentration: 24.9 µg/m3/44 minute Eye: Miosis (pupilliary constriction) JAPTO* 24,59,2004
inhalation
guinea pig 		lowest published toxic concentration: 52 µg/m3/38 minute Eye: Miosis (pupilliary constriction) JAPTO* 24,59,2004
inhalation
guinea pig 		lowest published toxic concentration: 127 µg/m3/22 minute Eye: Miosis (pupilliary constriction) JAPTO* 24,59,2004
inhalation
guinea pig 		lethal concentration (50 percent kill): 109 µg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes 		JAPTO* 24,501,2004
inhalation
guinea pig 		lethal concentration (50 percent kill): 109 µg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation JAPTO* 24,501,2004
inhalation
guinea pig 		lethal concentration (50 percent kill): 1,450 mg/m3/10 minute N/R JAPTO* 25,393,2005
inhalation
human 		lowest published toxic concentration: 87 µg/m3/10 minute Eye: Miosis (pupilliary constriction)

Lung, Thorax, or Respiration: Dyspnea 		TOXID9 72,160,2003
inhalation
human 		lowest published toxic concentration: 50 µg/m3/30 minute Eye: Miosis (pupilliary constriction)

Lung, Thorax, or Respiration: Dyspnea 		TOXID9 72,160,2003
inhalation
human 		lowest published toxic concentration: 35 µg/m3/1 hour Eye: Miosis (pupilliary constriction)

Lung, Thorax, or Respiration: Dyspnea 		TOXID9 72,160,2003
inhalation
human 		lowest published toxic concentration: 17 µg/m3/4 hour Eye: Miosis (pupilliary constriction)

Lung, Thorax, or Respiration: Dyspnea 		TOXID9 72,160,2003
inhalation
human 		lowest published toxic concentration: 13 µg/m3/8 hour Eye: Miosis (pupilliary constriction)

Lung, Thorax, or Respiration: Dyspnea 		TOXID9 72,160,2003
inhalation
human 		lowest published lethal concentration: 11 mg/m3/2 minute N/R JAPTO* 25,393,2005
inhalation
human 		lethal concentration (50 percent kill): 36 mg/m3/2 minute N/R JAPTO* 25,393,2005
inhalation
human 		lethal concentration (95 percent kill): 24 mg/m3/2 minute N/R JAPTO* 25,393,2005
inhalation
human 		lowest published lethal concentration: 90 mg/m3/10 minute N/R JAPTO* 25,393,2005
inhalation
human 		lethal concentration (50 percent kill): 280 mg/m3/10 minute N/R JAPTO* 25,393,2005
inhalation
human 		lethal concentration (95 percent kill): 660 mg/m3/10 minute N/R JAPTO* 25,393,2005
inhalation
human 		lowest published lethal concentration: 360 mg/m3/30 minute N/R JAPTO* 25,393,2005
inhalation
human 		lethal concentration (50 percent kill): 1,200 mg/m3/30 minute N/R JAPTO* 25,393,2005
inhalation
human 		lethal concentration (95 percent kill): 2,730 mg/m3/30 minute N/R JAPTO* 25,393,2005
inhalation
man 		lowest published toxic concentration: 90 µg/m3 Eye: Miosis (pupilliary constriction)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		ARTODN 56,201,1985
inhalation
monkey 		lowest published toxic concentration: 13.9 µg/m3/121 minute Eye: Miosis (pupilliary constriction) JAPTO* 24,59,2004
inhalation
monkey 		lowest published toxic concentration: 23.7 µg/m3/87 minute Eye: Miosis (pupilliary constriction) JAPTO* 24,59,2004
inhalation
monkey 		lowest published toxic concentration: 49 µg/m3/100 minute Eye: Miosis (pupilliary constriction) JAPTO* 24,59,2004
inhalation
monkey 		lowest published toxic concentration: 124 µg/m3/11 minute Eye: Miosis (pupilliary constriction) JAPTO* 24,59,2004
inhalation
monkey 		lowest published toxic concentration: 7.3 µg/m3/30 minute Brain and Coverings: Changes in surface EEG JAPTO* 24,475,2004
inhalation
monkey 		lowest published toxic concentration: 14.6 µg/m3/5 hour Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JAPTO* 24,475,2004
inhalation
monkey 		lethal concentration (50 percent kill): 90 mg/m3/2 minute N/R JAPTO* 25,393,2005
inhalation
monkey 		lethal concentration (50 percent kill): 670 mg/m3/10 minute N/R JAPTO* 25,393,2005
inhalation
mouse 		lethal concentration (50 percent kill): 5 mg/m3/30 minute N/R DEGEA3 15,2179,1960
inhalation
mouse 		lowest published toxic concentration: 0.5 ng/m3 Blood: Changes in spleen

Blood: Changes in leukocyte (WBC) count

Immunological Including Allergic: Decrease in cellular immune response 		TXCYAC 187,195,2003
inhalation
mouse 		lethal concentration (50 percent kill): 21.5 mg/m3/20 minute N/R JAPTO* 24,459,2004
inhalation
mouse 		lethal concentration (50 percent kill): 9 mg/m3/60 minute N/R JAPTO* 24,459,2004
inhalation
mouse 		lethal concentration (50 percent kill): 5 mg/m3/180 minute N/R JAPTO* 24,459,2004
inhalation
mouse 		lethal concentration (50 percent kill): 3.4 mg/m3/360 minute N/R JAPTO* 24,459,2004
inhalation
mouse 		lethal concentration (50 percent kill): 3.1 mg/m3/720 minute N/R JAPTO* 24,459,2004
inhalation
mouse 		lowest published toxic concentration: 3,348 mg/m3/9 minute Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		JAPTO* 24,459,2004
inhalation
mouse 		lowest published toxic concentration: 3,348 mg/m3/9 minute Gastrointestinal: Changes in structure or function of salivary glands JAPTO* 24,459,2004
inhalation
mouse 		lowest published lethal concentration: 6,696 mg/m3/18 minute Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JAPTO* 24,459,2004
inhalation
mouse 		lowest published toxic concentration: 12,360 mg/m3/30 minute Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		JAPTO* 24,459,2004
inhalation
mouse 		lowest published toxic concentration: 12,360 mg/m3/30 minute Gastrointestinal: Changes in structure or function of salivary glands JAPTO* 24,459,2004
inhalation
mouse 		lowest published toxic concentration: 24,720 mg/m3/60 minute Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPTO* 24,459,2004
inhalation
mouse 		lowest published lethal concentration: 25,900 mg/m3/50 minute Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) JAPTO* 24,459,2004
inhalation
mouse 		lowest published toxic concentration: 72,500 mg/m3/100 minute Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		JAPTO* 24,459,2004
inhalation
mouse 		lowest published toxic concentration: 72,500 mg/m3/100 minute Gastrointestinal: Changes in structure or function of salivary glands JAPTO* 24,459,2004
inhalation
mouse 		lowest published lethal concentration: 101,500 mg/m3/140 minute Peripheral Nerve and Sensation: Recording from peripheral motor nerve JAPTO* 24,459,2004
inhalation
mouse 		lowest published lethal concentration: 130,500 mg/m3/180 minute Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPTO* 24,459,2004
inhalation
mouse 		lowest published toxic concentration: 271,320 mg/m3/280 minute Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		JAPTO* 24,459,2004
inhalation
mouse 		lowest published toxic concentration: 271,320 mg/m3/280 minute Gastrointestinal: Changes in structure or function of salivary glands JAPTO* 24,459,2004
inhalation
mouse 		lowest published lethal concentration: 310,080 mg/m3/320 minute Peripheral Nerve and Sensation: Recording from peripheral motor nerve JAPTO* 24,459,2004
inhalation
mouse 		lowest published lethal concentration: 348,840 mg/m3/360 minute Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPTO* 24,459,2004
inhalation
mouse 		lowest published toxic concentration: 519,080 mg/m3/380 minute Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		JAPTO* 24,459,2004
inhalation
mouse 		lowest published toxic concentration: 519,080 mg/m3/380 minute Gastrointestinal: Changes in structure or function of salivary glands JAPTO* 24,459,2004
inhalation
mouse 		lowest published toxic concentration: 983,520 mg/m3/720 minute Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPTO* 24,459,2004
inhalation
mouse 		lowest published lethal concentration: 1,372,800 mg/m3/624 minute Peripheral Nerve and Sensation: Recording from peripheral motor nerve JAPTO* 24,459,2004
inhalation
mouse 		lethal concentration (50 percent kill): 430 mg/m3/2 minute N/R JAPTO* 25,393,2005
inhalation
mouse 		lethal concentration (50 percent kill): 3,160 mg/m3/10 minute N/R JAPTO* 25,393,2005
inhalation
mouse 		lowest published toxic dose: 0.5 mg/m3/60 minute Immunological Including Allergic: Uncharacterized (multiple organ involvement) INHTE5 16,509,2004
inhalation
mouse 		lowest published toxic concentration: 0.8 mg/m3/60 minute Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decreased immune response 		BCLPT* 94,139,2004
inhalation
mouse 		lethal concentration (50 percent kill): 0.981 mg/m3/2 hour N/R TPKVAL 9,7,1967
inhalation
mouse 		lethal concentration (50 percent kill): 0.17 ppm/2 hour N/R TPKVAL 9,7,1967
inhalation
pig 		lowest published toxic concentration: 42.7 µg/m3 Eye: Miosis (pupilliary constriction) TOXID9 72,159,2003
inhalation
pig 		lethal concentration (50 percent kill): 6,342 mg/m3/60 minute N/R TOXID9 44,161,2005
inhalation
pig 		lethal concentration (50 percent kill): 31,374 mg/m3/3 hour N/R TOXID9 44,161,2005
inhalation
pig 		lethal concentration (50 percent kill): 350 mg/m3/10 minute N/R JAPTO* 25,393,2005
inhalation
pig 		lowest published toxic dose: 0.43 mg/m3/60 minute Eye: Miosis (pupilliary constriction) INHTE5 18,143,2006
inhalation
pig 		lowest published toxic dose: 0.214 mg/m3/10 minute Eye: Miosis (pupilliary constriction) INHTE5 18,143,2006
inhalation
pig 		lowest published toxic dose: 0.22 mg/m3/180 minute Eye: Miosis (pupilliary constriction) INHTE5 18,143,2006
inhalation
rat 		lowest published toxic concentration: 6.9 µg/m3/10 minute Eye: Miosis (pupilliary constriction) TOXID9 72,160,2003
inhalation
rat 		lowest published toxic concentration: 4 µg/m3/30 minute Eye: Miosis (pupilliary constriction) TOXID9 72,160,2003
inhalation
rat 		lowest published toxic concentration: 2.8 µg/m3/1 hour Eye: Miosis (pupilliary constriction) TOXID9 72,160,2003
inhalation
rat 		lowest published toxic concentration: 1.4 µg/m3/4 hour Eye: Miosis (pupilliary constriction) TOXID9 72,160,2003
inhalation
rat 		lowest published toxic concentration: 1 µg/m3/8 hour Eye: Miosis (pupilliary constriction) TOXID9 72,160,2003
inhalation
rat 		lowest published lethal concentration: 380 µg/m3/10 minute N/R TOXID9 72,160,2003
inhalation
rat 		lowest published lethal concentration: 190 µg/m3/30 minute N/R TOXID9 72,160,2003
inhalation
rat 		lowest published lethal concentration: 130 µg/m3/1 hour N/R TOXID9 72,160,2003
inhalation
rat 		lowest published lethal concentration: 70 µg/m3/4 hour N/R TOXID9 72,160,2003
inhalation
rat 		lowest published lethal concentration: 51 µg/m3/8 hour N/R TOXID9 72,160,2003
inhalation
rat 		lowest published toxic concentration: 0.1 mg/m3/4 hour Brain and Coverings: Other degenerative changes

Liver: Other changes 		TOXID9 72,163,2003
inhalation
rat 		lowest published toxic concentration: 0.2 mg/m3/1 hour Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TXAPA9 184,67,2002
inhalation
rat 		lowest published toxic concentration: 2.1 mg/m3 Behavioral: Tremor TOSCF2 66,176,2002
inhalation
rat 		lowest published lethal concentration: 2.7 mg/m3 Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		TOSCF2 66,176,2002
inhalation
rat 		lowest published toxic concentration: 0.1 mg/m3/1 hour Brain and Coverings: Other degenerative changes

Eye: Miosis (pupilliary constriction) 		TOXID9 44,162,2005
inhalation
rat 		lowest published toxic concentration: 3.93 mg/m3/1 hour Eye: Miosis (pupilliary constriction)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOXID9 44,162,2005
inhalation
rat 		lethal concentration (50 percent kill): 228 mg/m3/2 minute N/R JAPTO* 25,393,2005
inhalation
rat 		lethal concentration (50 percent kill): 1,920 mg/m3/10 minute N/R JAPTO* 25,393,2005
inhalation
rat 		lowest published toxic concentration: 3.39 mg/m3/1 hour Vascular: Structural changes in vessels

Biochemical: Metabolism (intermediary): Other 		TOXID9 90,15,2006
inhalation
rat 		lowest published toxic concentration: 4 mg/m3 Vascular: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TOXID9 90,15,2006
inhalation
rat 		lowest published toxic dose: 18 mg/m3/10 minute Gastrointestinal: Changes in structure or function of salivary glands INHTE5 16,103,2004
inhalation
rat 		lethal dose (10 percent kill): 26.7 mg/m3/10 minute Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		INHTE5 16,103,2004
inhalation
rat 		lethal dose (10 percent kill): 21.6 mg/m3/10 minute Behavioral: Convulsions or effect on seizure threshold INHTE5 16,103,2004
inhalation
rat 		lethal dose (20 percent kill): 22.7 mg/m3/10 minute N/R INHTE5 16,103,2004
inhalation
rat 		lethal dose (70 percent kill): 23.8 mg/m3/10 minute N/R INHTE5 16,103,2004
inhalation
rat 		lethal dose (40 percent kill): 28.7 mg/m3/10 minute N/R INHTE5 16,103,2004
inhalation
rat 		lethal dose (80 percent kill): 35.9 mg/m3/10 minute N/R INHTE5 16,103,2004
inhalation
rat 		lowest published toxic dose: 5.6 mg/m3/60 minute Gastrointestinal: Changes in structure or function of salivary glands INHTE5 16,103,2004
inhalation
rat 		lethal dose (20 percent kill): 5.6 mg/m3/60 minute Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		INHTE5 16,103,2004
inhalation
rat 		lethal dose (60 percent kill): 6.1 mg/m3/60 minute N/R INHTE5 16,103,2004
inhalation
rat 		lowest published toxic dose: 6.1 mg/m3/60 minute Behavioral: Convulsions or effect on seizure threshold INHTE5 16,103,2004
inhalation
rat 		lethal dose (40 percent kill): 7 mg/m3/60 minute N/R INHTE5 16,103,2004
inhalation
rat 		lowest published toxic dose: 3.5 mg/m3/240 minute Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		INHTE5 16,103,2004
inhalation
rat 		lethal dose (50 percent kill): 3.5 mg/m3/240 minute Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		INHTE5 16,103,2004
inhalation
rat 		lethal dose (70 percent kill): 5.6 mg/m3/240 minute N/R INHTE5 16,103,2004
inhalation
rat 		lethal dose (50 percent kill): 23.5 mg/m3/10 minute N/R INHTE5 16,103,2004
inhalation
rat 		lethal dose (50 percent kill): 5.9 mg/m3/60 minute N/R INHTE5 16,103,2004
inhalation
rat 		lethal dose (50 percent kill): 5.4 mg/m3/240 minute N/R INHTE5 16,103,2004
inhalation
rat 		lowest published toxic dose: 1.25 mg/m3/60 minute Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		INHTE5 16,531,2004
inhalation
rat 		lowest published toxic concentration: 0.4 mg/m3 Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TOSCF2 97,181,2007
inhalation
rat 		lowest published toxic concentration: 0.2 mg/m3/1 hour Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TIHEEC 17,294,2001
inhalation
rabbit 		lethal concentration (50 percent kill): 156 mg/m3/2 minute N/R JAPTO* 25,393,2005
inhalation
rabbit 		lethal concentration (50 percent kill): 1,220 mg/m3/10 minute N/R JAPTO* 25,393,2005
intramuscular
dog 		lethal dose (50 percent kill): 0.3 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JJATDK 26,439,2006
intramuscular
guinea pig 		lowest published toxic dose: 56 µg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Convulsions or effect on seizure threshold 		ARTODN 77,167,2003
intramuscular
man 		lowest published lethal dose: 30 µg/kg N/R JCINAO 37,350,1958
intramuscular
monkey 		lethal dose (50 percent kill): 22,300 ng/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands

Skin and Appendages: Other: Hair 		FAATDF 5,S169,1985
intramuscular
monkey 		lowest published toxic dose: 2.93 µg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXCYAC 231,11,2007
intramuscular
mouse 		lethal dose (50 percent kill): 164 µg/kg N/R JMCMAR 31,807,1988
intramuscular
rat 		lethal dose (50 percent kill): 0.1 mg/kg Brain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JTEHD6 61,695,2000
intramuscular
rat 		lowest published toxic dose: 1 µg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		FCTOD7 40,1327,2002
intramuscular
rat 		lethal dose (50 percent kill): 100 µg/kg N/R BCPCA6 65,2041,2003
intramuscular
rat 		lowest published toxic dose: 75 µg/kg Peripheral Nerve and Sensation: Sensory syndrome diagnostic of central lesion TOSCF2 66,148,2002
intramuscular
rat 		lowest published lethal dose: 90 µg/kg Peripheral Nerve and Sensation: Sensory syndrome diagnostic of central lesion

Behavioral: Convulsions or effect on seizure threshold

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		TOSCF2 66,148,2002
intramuscular
rat 		lethal dose (50 percent kill): 100 µg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Other 		TOXID9 1,84,2001
intramuscular
rat 		lowest published lethal dose: 118 µg/kg Brain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 209,74,2005
intramuscular
rat 		lowest published toxic dose: 90 mg/kg Brain and Coverings: Other degenerative changes JPETAB 313,1082,2005
intramuscular
rat 		lowest published toxic dose: 0.108 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold 		NRTXDN 27,277,2006
intraperitoneal
mouse 		lethal dose (50 percent kill): 283 µg/kg N/R AIPTAK 172,62,1968
intraperitoneal
rat 		lethal dose (50 percent kill): 218 µg/kg N/R JPETAB 139,390,1963
intraperitoneal
rat 		lowest published toxic dose: 960 µg/kg Behavioral: Change in motor activity (specific assay) FCTOD7 40,1327,2002
intraperitoneal
rabbit 		lethal dose (50 percent kill): 275 mg/kg N/R ENTOX* -,201,2005
intravenous
cat 		lethal dose (50 percent kill): 22 µg/kg N/R JPETAB 132,50,1961
intravenous
dog 		lethal dose (50 percent kill): 19 µg/kg N/R JPETAB 132,50,1961
intravenous
monkey 		lethal dose (50 percent kill): 20 µg/kg N/R JTEHF8 59,387,2000
intravenous
mouse 		lethal dose (50 percent kill): 109 µg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Incontinence 		JTEHD6 26,437,1989
intravenous
pig 		lethal dose (50 percent kill): 15 µg/kg N/R JTEHF8 59,387,2000
intravenous
rat 		lethal dose (50 percent kill): 39 µg/kg N/R JPETAB 139,390,1963
intravenous
rabbit 		lethal dose (50 percent kill): 15 µg/kg N/R JMPCAS 3,353,1961
multiple
rat 		lowest published toxic dose: 430 µg/m3/240 minute Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase HETOEA 24,363,2005
oral
human 		lowest published toxic dose: 2 µg/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Gastrointestinal: Nausea or vomiting 		JCINAO 37,350,1958
oral
man 		lowest published toxic dose: 102 µg/kg/3 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JCINAO 37,350,1958
oral
rat 		lethal dose (50 percent kill): 550 µg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Changes in structure or function of salivary glands 		NTIS** PB158-508
oral
rat 		lowest published toxic dose: 380 µg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase FCTOD7 40,1327,2002
subcutaneous
cat 		lethal dose (50 percent kill): 30 µg/kg N/R TXAPA9 91,55,1987
subcutaneous
chicken 		lethal dose (50 percent kill): 16 µg/kg N/R FCTOD7 40,1327,2002
subcutaneous
guinea pig 		lethal dose (50 percent kill): 30 µg/kg N/R CJPPA3 46,109,1968
subcutaneous
guinea pig 		lowest published lethal dose: 84 µg/kg Brain and Coverings: Changes in surface EEG

Brain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold 		TXAPA9 188,69,2003
subcutaneous
guinea pig 		lowest published lethal dose: 210 µg/kg Brain and Coverings: Changes in surface EEG

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression 		TXCYAC 188,197,2003
subcutaneous
guinea pig 		lowest published toxic dose: 0.245 mg/kg Behavioral: Tremor

Behavioral: Rigidity (includes catalepsy)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NRTXDN 27,485,2006
subcutaneous
guinea pig 		lowest published lethal dose: 84 µg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands 		JPETAB 320,154,2007
subcutaneous
hamster 		lethal dose (50 percent kill): 95 µg/kg N/R CJPPA3 46,109,1968
subcutaneous
mouse 		lethal dose (50 percent kill): 60 µg/kg N/R DEGEA3 15,2179,1960
subcutaneous
rat 		lethal dose (50 percent kill): 103 µg/kg N/R BJPCBM 39,822,1970
subcutaneous
rat 		lowest published toxic dose: 120 µg/kg Brain and Coverings: Changes in surface EEG

Behavioral: Convulsions or effect on seizure threshold 		HBPTO* 2,1027,2001
subcutaneous
rat 		lowest published lethal dose: 144 µg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression 		TXAPA9 192,86,2003
subcutaneous
rat 		lowest published lethal dose: 144 µg/kg Brain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		ARTODN 76,650,2002
subcutaneous
rat 		lowest published lethal dose: 144 µg/kg Behavioral: Convulsions or effect on seizure threshold ARTODN 78,34,2004
subcutaneous
rabbit 		lethal dose (50 percent kill): 30 µg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness 		TXAPA9 40,109,1977
subcutaneous
rabbit 		lethal dose (50 percent kill): 30 mg/kg N/R ENTOX* -,201,2005
skin
dog 		lethal dose (50 percent kill): 10.8 mg/kg N/R ENTOX* -,201,2005
skin
human 		lethal dose (50 percent kill): 28 mg/kg Lung, Thorax, or Respiration: Dyspnea SCJUAD 3(4),33,1967
skin
mouse 		lethal dose (50 percent kill): 1,080 µg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Changes in structure or function of salivary glands 		NTIS** PB158-508
skin
pig 		lethal dose (50 percent kill): 116 mg/kg N/R JTEHF8 59,387,2000
skin
rat 		lethal dose (50 percent kill): 2,500 µg/kg N/R JTEHF8 59,387,2000
skin
rabbit 		lethal dose (50 percent kill): 925 µg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Changes in structure or function of salivary glands 		NTIS** PB158-508
skin
rabbit 		lethal dose (50 percent kill): 4.4 mg/kg N/R ENTOX* -,201,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 5 mg/m3/20 minute/10 day- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		JJATDK 13,143,1993
inhalation
mouse 		lowest published toxic concentration: 5 mg/m3/10 day- intermittent Behavioral: Muscle weakness

Behavioral: Ataxia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		FCTOD7 40,1327,2002
inhalation
mouse 		lowest published toxic concentration: 0.8 mg/m3/1 hour/3 day- intermittent Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decreased immune response 		BCLPT* 94,139,2004
inhalation
rat 		lowest published toxic concentration: 0.2 mg/m3/1 hour/5 day- intermittent Immunological Including Allergic: Decreased immune response TOXID9 72,159,2003
inhalation
rat 		lowest published toxic concentration: 0.2 mg/m3/5 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TXAPA9 184,67,2002
inhalation
rat 		lowest published toxic concentration: 0.4 mg/m3/10 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TXAPA9 184,67,2002
inhalation
rat 		lowest published toxic concentration: 0.2 mg/m3/5 day- intermittent Immunological Including Allergic: Decrease in cellular immune response TXAPA9 184,82,2002
inhalation
rat 		lowest published toxic concentration: 0.4 mg/m3/5 day- intermittent Endocrine: Other changes

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response 		TXAPA9 184,82,2002
inhalation
rat 		lowest published toxic concentration: 0.2 mg/m3/1 hour/5 day- intermittent Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response 		TOXID9 44,5,2005
inhalation
rat 		lowest published toxic concentration: 0.2 mg/m3/10 day- intermittent Brain and Coverings: Other degenerative changes

Blood: Changes in spleen

Blood: Other changes 		TOXID9 60,240,2001
inhalation
rat 		lowest published toxic concentration: 0.2 mg/m3/10 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TOXID9 60,240,2001
inhalation
rat 		lowest published toxic concentration: 3.39 mg/m3/3 day- intermittent Eye: Miosis (pupilliary constriction)

Behavioral: Tolerance 		TOXID9 90,15,2006
inhalation
rat 		lowest published toxic concentration: 0.4 mg/m3/1 hour/5 day- intermittent Lung, Thorax, or Respiration: Other changes

Endocrine: Other changes

Immunological Including Allergic: Decrease in cellular immune response 		TOSCF2 97,181,2007
inhalation
rat 		lowest published toxic concentration: 0.2 mg/m3/1 hour/5 day- intermittent Brain and Coverings: Other degenerative changes

Endocrine: Other changes

Immunological Including Allergic: Decrease in cellular immune response 		TIHEEC 17,294,2001
oral
rat 		lowest published toxic dose: 4,875 µg/kg/13 week- intermittent Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Lung, Thorax, or Respiration: Dyspnea 		JTEHF8 59,387,2000
oral
rat 		lowest published toxic dose: 3,800 µg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Blood: Other changes 		FCTOD7 40,1327,2002
subcutaneous
cat 		lowest published toxic dose: 35 µg/kg/10 day- intermittent Peripheral Nerve and Sensation: Sensory change involving peripheral nerve TXAPA9 91,55,1987
subcutaneous
guinea pig 		lowest published toxic dose: 50.4 µg/kg/2 day- intermittent Behavioral: Tremor

Behavioral: Excitement 		TXAPA9 215,119,2006
subcutaneous
guinea pig 		lowest published toxic dose: 100.8 µg/kg/4 day- intermittent Behavioral: Convulsions or effect on seizure threshold TXAPA9 215,119,2006
subcutaneous
guinea pig 		lowest published toxic dose: 226.8 µg/kg/11 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXAPA9 215,119,2006
subcutaneous
guinea pig 		lowest published toxic dose: 105 µg/kg/5 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXAPA9 215,119,2006
subcutaneous
guinea pig 		lowest published toxic dose: 33.6 µg/kg/2 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TXAPA9 215,119,2006
subcutaneous
guinea pig 		lowest published toxic dose: 168 µg/kg/10 day- intermittent Behavioral: Alteration of classical conditioning TXAPA9 215,119,2006
subcutaneous
guinea pig 		lowest published toxic dose: 168 µg/kg/12 day- intermittent Brain and Coverings: Changes in surface EEG TXAPA9 215,119,2006
subcutaneous
mouse 		lowest published toxic dose: 16 µg/kg/2 day- intermittent Cardiac: Other changes TOXID9 44,162,2005
subcutaneous
mouse 		: 16 µg/kg/2 day- intermittent Brain and Coverings: Other degenerative changes

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes 		EXNEAC 203,110,2007
subcutaneous
rat 		lowest published toxic dose: 4,250 µg/kg/85 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		APTOA6 57,234,1985
subcutaneous
rat 		lowest published toxic dose: 1 mg/kg/40 day- intermittent Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		RCOCB8 48,415,1985
subcutaneous
rat 		lowest published toxic dose: 187.5 µg/kg/7 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JPETAB 304,1111,2003
subcutaneous
rat 		lowest published toxic dose: 562.5 µg/kg/3 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Change in motor activity (specific assay)

Behavioral: Change in psychophysiological tests 		JPETAB 304,1111,2003
subcutaneous
rat 		lowest published toxic dose: 562.5 µg/kg/3 week- intermittent Cardiac: Change in rate JJATDK 26,410,2006
subcutaneous
rat 		lowest published toxic dose: 562.5 µg/kg/3 week- intermittent Brain and Coverings: Other degenerative changes

Autonomic Nervous System: Other (direct) parasympathomimetic

Biochemical: Metabolism (intermediary): Other 		ARTODN 80,761,2006
unreported route
chicken 		lowest published toxic dose: 750 µg/kg/6 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases FCTOD7 40,1327,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
CHREAY 48,225,1951
TOXICOLOGY REVIEW
TXAPA9 184,116,2002
TOXICOLOGY REVIEW
CPEMM* 3,239,2002
TOXICOLOGY REVIEW
CCATAR 366,1,2006
TOXICOLOGY REVIEW
TXCYAC 214,221,2005
TOXICOLOGY REVIEW
ENTOX* -,588,2005
TOXICOLOGY REVIEW
EJPHAZ 553,10,2006
TOXICOLOGY REVIEW
ENTOX* -,201,2005
TOXICOLOGY REVIEW
ENTOX* -,308,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
CCATAR Clinica Chimica Acta. (Elsevier Science B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1956-
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
CJPPA3 Canadian Journal of Physiology and Pharmacology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.42- 1964-
CPEMM* Clinical Pediatric Emergency Medicine (Philadelphia, PA : W.B. Saunders Co.)
DEGEA3 Deutsche Gesundheitswesen. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EXNEAC Experimental Neurology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SCJUAD Science Journal. (London, UK) V.1-7, 1965-71. For publisher information, see NWSCAL.
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a chemical warfare agent

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Human Data

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