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Phosphonic acid, (1 - hydroxyethylidene) di - , disodium salt

RTECS #: SZ8562240

CAS #: 7414-83-7

UPDATE: August 2006 MW: 250.00 MF: C2H6O7P2•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. (1 - Hydroxyethane - 1,1 - diyl) diphosphonic acid disodium salt
  2. (1 - Hydroxyethylidene) diphosphonic acid, disodium salt
  3. 1 - Hydroxyethylidene - 1,1 - diphosphonic acid disodium salt
  4. BA 49280E
  5. Didronel R
  6. Disodium dihydrogen (1 - hydroxyethylidene) diphosphonate
  7. Disodium ethanol - 1,1 - diphosphonate
  8. Disodium ethydronate
  9. Disodium etidronate
  10. Disodium 1 - hydroxyethylidene phosphonate
  1. Ethane - 1 - hydroxy - 1,1 - diphosphonic acid, disodium salt
  2. Etidronate disodium
  3. Ostedron
  4. Phosphonic acid, (1 - hydroxyethane - 1,1 - diyl) di - , disodium salt
  5. SM - 5600
  6. Sodium ethane - 1 - hydroxy - 1,1 - diphosphonate
  7. Sodium ethidronate
  8. Sodium ethydronate
  9. Sodium etidronate
  10. Turpinal 2NZ


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 1 mmol/L KSRNAM 23,1343,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 2,500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		TXAPA9 18,548,1971
oral
rat 		lowest published toxic dose: 5,500 mg/kg (1-22 day pregnant) Reproductive: Effects on fertility: Other measures of fertility TXAPA9 18,548,1971
oral
rat 		lowest published toxic dose: 86 gm/kg (9 week male/2 week prior to copulation/1-7 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		KSRNAM 23,1317,1989
oral
rat 		lowest published toxic dose: 11 gm/kg (7-17 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		KSRNAM 23,1317,1989
oral
rat 		lowest published toxic dose: 7,800 mg/kg (17-22 day pregnant/20 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Physical 		KSRNAM 23,1317,1989
oral
rabbit 		lowest published toxic dose: 1,500 µg/kg (2-16 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		TXAPA9 18,548,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 250 mg/kg N/R BAXXDU #2096889
intravenous
dog 		lowest published lethal dose: 32 mg/kg Cardiac: Arrythmias (indlucing changes in conduction)

Cardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Dyspnea 		JPMSAE 73,1097,1984
intravenous
mouse 		lethal dose (50 percent kill): 49 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold 		KSRNAM 23,1251,1989
intravenous
rat 		lethal dose (50 percent kill): 35 mg/kg N/R BAXXDU #2096889
oral
dog 		lowest published lethal dose: 500 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Ataxia

Gastrointestinal: Nausea or vomiting 		KSRNAM 23,1257,1989
oral
mouse 		lethal dose (50 percent kill): 1,900 mg/kg N/R NIIRDN -,221,1995
oral
mouse 		lowest published lethal dose: 500 mg/kg Musculoskeletal: Joints

Musculoskeletal: Other changes 		ARTODN 79,475,2005
oral
rat 		lethal dose (50 percent kill): 1,340 mg/kg Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli TXAPA9 22,661,1972
oral
rabbit 		lethal dose (50 percent kill): 581 mg/kg Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Interstitial nephritis 		TXAPA9 22,661,1972
oral
woman 		lowest published toxic dose: 240 mg/kg/26 week- intermittent Ear: Change in acuity

Ear: Tinnitus 		PGMJAO 74,363,1998
oral
woman 		lowest published toxic dose: 588 mg/kg/28 week- intermittent Musculoskeletal: Osteomalacia

Musculoskeletal: Other changes 		DRSAEA 7,162,1992
oral
woman 		lowest published toxic dose: 240 mg/kg/22 week- intermittent Ear: Change in acuity

Ear: Tinnitus 		PGMJAO 74,363,1998
subcutaneous
mouse 		lethal dose (50 percent kill): 260 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		KSRNAM 23,1251,1989
subcutaneous
mouse 		lowest published lethal dose: 50 mg/kg Musculoskeletal: Joints

Musculoskeletal: Other changes 		ARTODN 79,475,2005
subcutaneous
rat 		lethal dose (50 percent kill): 372 mg/kg Eye: Chromodacryorrhea

Eye: Ptosis

Behavioral: Somnolence (general depressed activity) 		KSRNAM 23,1251,1989


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 14,560 mg/kg/13 week- continuous Endocrine: Other changes

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		KSRNAM 23,1257,1989
oral
dog 		lowest published toxic dose: 14,560 mg/kg/52 week- intermittent Behavioral: Ataxia

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase 		KSRNAM 23,1289,1989
oral
mouse 		lowest published toxic dose: 27,300 mg/kg/2 year- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		YAKUD5 39,207,1997
oral
rat 		lowest published toxic dose: 3,130 mg/kg/52 week- intermittent Blood: Normocytic anemia

Musculoskeletal: Other changes 		YAKUD5 32,2686,1990
oral
rat 		lowest published toxic dose: 72,800 mg/kg/26 week- intermittent Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Ca 		SIIPD4 10,447,1983
oral
rat 		lowest published toxic dose: 14,560 mg/kg/2 year- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		YAKUD5 39,207,1997


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
OPHTH* 111,1275,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2888;
Number of Industries 2;
Total Number of Facilities 78;
Number of Occupations 2;
Total Number of Employees Exposed 1,099


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
DRSAEA Drug Safety. (Adis International Ltd., Private Bag 65901, Mairangi Bay, Auckland 10, New Zealand) V.5- 1990-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
OPHTH* Ophthalmology (Copyright 2006 American Academy of Ophthalmology) V.105- 1998-
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925-
SIIPD4 Shanghai Diyi Yixueyuan Xuebao. Journal of the Shanghai First Medical College. (Beijing, Peop. Rep. China) 1956-V.12, 1985. For publisher information, see SYDXEE.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used for the treatment of Paget's disease

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 187285-10-5
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