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Phosphonic acid, diisopropyl ester

RTECS #: SZ7660000

CAS #: 1809-20-7

UPDATE: February 2006 MW: 166.18 MF: C6H15O3P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Diisopropyl hydrogen phosphite
  2. Diisopropyl phosphite
  3. Diisopropylphosphonate
  1. Isopropyl phosphonate
  2. O,O - Diisopropyl phosphonate
  3. Phosphonic acid, bis (1 - methylethyl) ester


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 5 mg/plate (+enzymatic activation step) MUREAV 28,405,1975


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration (50 percent kill): 9,010 mg/m3 Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands

Lung, Thorax, or Respiration: Other changes 		GTPZAB 29(11),51,1985
inhalation
mouse 		lethal concentration (50 percent kill): 9,085 mg/m3 Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands

Lung, Thorax, or Respiration: Other changes 		GTPZAB 29(11),51,1985
inhalation
rat 		lethal concentration (50 percent kill): 9,600 mg/m3 Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands

Lung, Thorax, or Respiration: Other changes 		GTPZAB 29(11),51,1985
oral
mouse 		lethal dose (50 percent kill): 1,590 mg/kg N/R GTPZAB 29(11),51,1985
oral
rat 		lethal dose (50 percent kill): 1,700 mg/kg N/R GTPZAB 29(11),51,1985
skin
rabbit 		lethal dose (50 percent kill): 5,700 mg/kg N/R ALBRW* #OPB-3,1984
unreported route
guinea pig 		lethal dose (50 percent kill): 1,500 mg/kg N/R GISAAA 51(7),78,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
unreported route
rat 		lowest published toxic dose: 2,074 mg/kg/61 day- intermittent Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 51(7),78,1986
unreported route
rat 		lowest published toxic dose: 6,188 mg/kg/26 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		GISAAA 53(3),70,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 4 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1834;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 50


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ALBRW* Albright & Wilson Inc. (P.O. Box 26229, Richmond, VA 23260-6229)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-

RTECS Compound Description:
   Mutagen

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