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p - Phenylenediamine, N,N - dimethyl -

RTECS #: ST0874000

CAS #: 99-98-9

UPDATE: May 2008 MW: 136.22 MF: C8H12N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1,4 - Benzenediamine, N,N - dimethyl - (9CI)
  2. 4 - (Dimethylamino) aniline
  3. 4 - (Dimethylamino) benzenamine
  4. 4 - (Dimethylamino) phenylamine
  5. C.I. 76075
  6. DMPD
  1. Dimethyl - p - phenylenediamine
  2. N,N - Dimethyl - p - fenylendiamin (Czech)
  3. N,N - Dimethyl - p - phenylenediamine
  4. p - (Dimethylamino) aniline
  5. p - Aminodimethylaniline
  6. p - Dimethylaminophenylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 10 mg/L MUREAV 241,175,1990
unscheduled DNA synthesis hamster liver 100 µmol/L MUREAV 136,255,1984
unscheduled DNA synthesis rat liver 100 µmol/L MUREAV 136,255,1984
mutation in microorganisms Escherichia coli 50 µg/plate (+enzymatic activation step) FCTOD7 45,1670,2007
mutation in microorganisms Salmonella typhimurium 5 µg/plate (-enzymatic activation step) AEMIDF 42,641,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published lethal concentration: 240 ppb Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea 		JIDHAN 4,386,1923
inhalation
rabbit 		lowest published lethal concentration: 500 ppb Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea 		JIDHAN 4,386,1923
intraperitoneal
dog 		lowest published lethal dose: 10 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		JPETAB 95,262,1949
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 45 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		JPETAB 95,262,1949
intraperitoneal
mouse 		lethal dose (50 percent kill): 25 mg/kg N/R JPETAB 95,262,1949
intraperitoneal
rat 		lethal dose (50 percent kill): 21 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		JPETAB 95,262,1949
intraperitoneal
rabbit 		lethal dose (50 percent kill): 100 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		JPETAB 95,262,1949
intravenous
dog 		lowest published lethal dose: 51 mg/kg N/R JIDHAN 4,386,1923
oral
cat 		lowest published lethal dose: 20 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Respiratory stimulation 		JIDHAN 4,386,1923
oral
mouse 		lethal dose (50 percent kill): 30 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		NTIS** OTS0555326
oral
rat 		lethal dose (50 percent kill): 50 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		NTIS** OTS0555326
oral
rabbit 		lowest published lethal dose: 150 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma 		JIDHAN 4,386,1923
subcutaneous
guinea pig 		lowest published lethal dose: 100 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Respiratory stimulation 		JIDHAN 4,386,1923
subcutaneous
rat 		lowest published lethal dose: 50 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma 		JIDHAN 4,386,1923
subcutaneous
rabbit 		lowest published lethal dose: 60 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma 		JIDHAN 4,386,1923
skin
dog 		lowest published lethal dose: 84 mg/kg N/R JIDHAN 4,386,1923
skin
guinea pig 		lethal dose (50 percent kill): 500 µL/kg N/R NTIS** OTS0555326
skin
human 		lowest published toxic dose: 14 µg/kg Blood: Hemorrhage

Skin: After topical application: Primary irritation

Skin: After topical application: Dermatitis, allergic 		JIDHAN 4,386,1923
skin
rabbit 		lowest published lethal dose: 60 mg/kg Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis 		JIDHAN 4,386,1923


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 649 mg/kg/11 day- continuous Liver: Changes in liver weight

Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0555326


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7141;
Number of Industries 1;
Total Number of Facilities 10;
Number of Occupations 1;
Total Number of Employees Exposed 50;
Total Number of Female Employees Exposed 50


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AEMIDF Applied and Environmental Microbiology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.31- 1976-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data

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