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m - Phenylenediamine, 4 - (phenylazo) - , hydrochloride

RTECS #: ST3380000

CAS #: 532-82-1

UPDATE: October 1997 MW: 248.74 MF: C12H12N4•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2,4 - Diaminoazobenzene hydrochloride
  2. 4 - (Phenylazo) - 1,3 - benzenediamine, monohydrochloride
  3. 4 - (Phenylazo) - m - phenylenediamine, monohydrochloride
  4. 4 - Phenylazo - m - phenylenediamine hydrochloride
  5. Astra Chrysoidine R
  6. Brasilazina Orange Y
  7. C.I. 11270
  8. C.I. Basic Orange 2
  9. Calcozine Orange YS
  10. Chrysoidine (II)
  11. Chrysoidine J
  12. Chrysoidine M
  13. Chrysoidine Orange
  14. Chrysoidine PRL
  15. Chrysoidine PRR
  16. Chrysoidine SL
  17. Chrysoidine special (biological stain and indicator)
  18. Chrysoidine SS
  19. Chrysoidine Y
  20. Chrysoidine Y crystals
  21. Chrysoidine Y EX
  22. Chrysoidine YGH
  23. Chrysoidine YL
  1. Chrysoidine YN
  2. Chrysoidin FB
  3. Chrysoidin Y
  4. Chrysoidin YN
  5. Chrysoidin
  6. Chrysoidine
  7. Chrysoidine A
  8. Chrysoidine B
  9. Chrysoidine C crystals
  10. Chrysoidine G
  11. Chrysoidine GN
  12. Chrysoidine GS
  13. Chrysoidine HR
  14. Chrysoidine hydrochloride
  15. Chryzoidyna F.B. (Polish)
  16. Diazocard chrysoidine G
  17. Elcozine chrysoidine Y
  18. Leather Orange HR
  19. Nippon Kagaku Chrysoidine
  20. Pure Chrysoidine YBH
  21. Sugai chrysoidine
  22. Tertrophene Brown CG
  23. Verona Chrysoidine GN


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 10 µg/plate (-enzymatic activation step) ENMUDM 9(Suppl 9),1,1987
mutation in microorganisms Saccharomyes cerevisiae 100 µg/L (-enzymatic activation step) VINIT* #428-84
phage inhibition capacity Escherichia coli 100 mmol/L MDMIAZ 31,11,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 93,600 mg/kg/56 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		LANCAO 1,564,1982
oral
mouse 		toxic dose : 94 gm/kg/57 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		XPHPAW 149,365,1969


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): 6,670 mg/kg Behavioral: Excitement

Behavioral: Muscle weakness

Gastrointestinal: Nausea or vomiting 		TLSMA6 105,42,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 5,153 mg/kg/17 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases 		TLSMA6 105,42,1974


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 8,91,1975
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 7,169,1987
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,169,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2097;
Number of Industries 7;
Total Number of Facilities 291;
Number of Occupations 13;
Total Number of Employees Exposed 3,278
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M2097;
Number of Industries 7;
Total Number of Facilities 315;
Number of Occupations 14;
Total Number of Employees Exposed 6,996;
Total Number of Female Employees Exposed 2,725


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a colorant in textiles, paper, leather, inks, wood and biological stains
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
MDMIAZ Medycyna Doswiadczalna i Mikrobiologia. For English translation, see EXMMAV. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1949-
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
VINIT* Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii (VINITI). All-Union Institute of Scientific and Technical Information. (Moscow, USSR) Use information broker to obtain publications.
XPHPAW U.S. Public Health Service Publication. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) No.1- 1950-

Used as a colorant in textiles, paper, leather, inks, wood and biological stains

NIOSH PROFILE (AMINOAZOBENZENES), SRC, 11/81

RTECS Compound Description:
   Tumorigen
   Mutagen

 Click Here for Additional Information about RTECS

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