RTECS:SS8400000 The Registry of Toxic Effects of Chemical Substances

p - Phenylenediamine, N,N' - bis (1,4 - dimethylpentyl) -

RTECS #: SS8400000

CAS #: 3081-14-9

UPDATE: February 2008 MW: 304.58 MF: C₂₀H₃₆N₂

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

1,4 - Benzenediamine, N,N' - bis (1,4 - dimethylpentyl) -

77PPD

Antioxidant 4030

Eastozone

Eastozone 33

Elastozone 33

Flexzone 4L

N,N' - Bis (1,4 - dimethylpentyl) - p - phenylenediamine

N,N - Di (1,4 - dimethylpentyl) - p - phenylenediamine

NCI - C56337

Santoflex 77

Tenamene 4

UOP 788

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lethal concentration : >400 mg/m³/6 hour N/R KODAK* 21MAY1971
inhalation
rat lowest published toxic concentration: 0.4 gm/m³/4 hour N/R TPKVAL 12,132,1971
inhalation
rat lowest published toxic concentration: 0.53 gm/m³/4 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia TPKVAL 12,132,1971
intraperitoneal
mouse lethal dose (50 percent kill): 400 mg/kg N/R IPSTB3 3,93,1976
intraperitoneal
rat lethal dose (50 percent kill): 800 mg/kg N/R IPSTB3 3,93,1976
ocular
rabbit lowest published toxic dose: 0.25 mL/kg Eye: Conjunctiva irritation TPKVAL 12,132,1971
oral
mouse lethal dose (50 percent kill): 800 mg/kg N/R IPSTB3 3,93,1976
oral
rat lethal dose (50 percent kill): 750 mg/kg N/R TPKVAL 12,132,1971

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 0.4 gm/m³/30 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Kidney, Ureter, and Bladder: Other changes in urine composition TPKVAL 12,132,1971
inhalation
rat lowest published toxic concentration: 0.1 gm/m³/4 hour/153 day- intermittent Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Proteinuria TPKVAL 12,132,1971
oral
rat lowest published toxic dose: 1.5 mg/kg/10 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TPKVAL 12,132,1971

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m³, JUN2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2940;
Number of Industries 1;
Total Number of Facilities 34;
Number of Occupations 4;
Total Number of Employees Exposed 255
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M2940;
Number of Industries 2;
Total Number of Facilities 13;
Number of Occupations 7;
Total Number of Employees Exposed 6,499;
Total Number of Female Employees Exposed 649

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as antiozonant for general-purpose elastomers
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8854
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Used as antiozonant for general-purpose elastomers

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SYNONYMS:
1,4 - Benzenediamine, N,N' - bis (1,4 - dimethylpentyl) - 77PPD Antioxidant 4030 Eastozone Eastozone 33 Elastozone 33 Flexzone 4L	N,N' - Bis (1,4 - dimethylpentyl) - p - phenylenediamine N,N - Di (1,4 - dimethylpentyl) - p - phenylenediamine NCI - C56337 Santoflex 77 Tenamene 4 UOP 788

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lethal concentration : >400 mg/m³/6 hour	N/R	KODAK* 21MAY1971
inhalation rat	lowest published toxic concentration: 0.4 gm/m³/4 hour	N/R	TPKVAL 12,132,1971
inhalation rat	lowest published toxic concentration: 0.53 gm/m³/4 hour	Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Behavioral: Ataxia	TPKVAL 12,132,1971
intraperitoneal mouse	lethal dose (50 percent kill): 400 mg/kg	N/R	IPSTB3 3,93,1976
intraperitoneal rat	lethal dose (50 percent kill): 800 mg/kg	N/R	IPSTB3 3,93,1976
ocular rabbit	lowest published toxic dose: 0.25 mL/kg	Eye: Conjunctiva irritation	TPKVAL 12,132,1971
oral mouse	lethal dose (50 percent kill): 800 mg/kg	N/R	IPSTB3 3,93,1976
oral rat	lethal dose (50 percent kill): 750 mg/kg	N/R	TPKVAL 12,132,1971

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published toxic concentration: 0.4 gm/m³/30 day- intermittent	Peripheral Nerve and Sensation: Recording from peripheral motor nerve Kidney, Ureter, and Bladder: Other changes in urine composition	TPKVAL 12,132,1971
inhalation rat	lowest published toxic concentration: 0.1 gm/m³/4 hour/153 day- intermittent	Kidney, Ureter, and Bladder: Urine volume decreased or anuria Kidney, Ureter, and Bladder: Proteinuria	TPKVAL 12,132,1971
oral rat	lowest published toxic dose: 1.5 mg/kg/10 day- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TPKVAL 12,132,1971

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Occupational Exposure Limit - RUSSIA	short term exposure limit 5 mg/m³, JUN2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: M2940; Number of Industries 1; Total Number of Facilities 34; Number of Occupations 4; Total Number of Employees Exposed 255
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: M2940; Number of Industries 2; Total Number of Facilities 13; Number of Occupations 7; Total Number of Employees Exposed 6,499; Total Number of Female Employees Exposed 649

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as antiozonant for general-purpose elastomers
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8854
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
IPSTB3	International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
KODAK*	Kodak Company Reports. (343 State St., Rochester, NY 14650)
TPKVAL	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-