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Phenothiazin - 5 - ium, 3 - amino - 7 - (dimethylamino) - , chloride

RTECS #: SP5660000

CAS #: 531-53-3

UPDATE: September 1997 MW: 291.82 MF: C14H14N3S•Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. 3 - Amino - 7 - (dimethylamino) phenothiazin - 5 - ium chloride
  2. Azur A
  3. Azure A
  1. C.I. 52005
  2. Dimethylthionine
  3. asym - Dimethyl - 3,7 - diaminophenazathionium chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 20 µmol/L/5 hour- continuous ENMUDM 1,27,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
mouse 		lethal dose (50 percent kill): 59,040 µg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Lung, Thorax, or Respiration: Other changes 		SMBUA9 9,96,1951
intravenous
rat 		lethal dose (50 percent kill): 37,720 µg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Lung, Thorax, or Respiration: Other changes 		SMBUA9 9,96,1951
intravenous
rabbit 		lethal dose (50 percent kill): 19,340 µg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Lung, Thorax, or Respiration: Other changes 		SMBUA9 9,96,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3031;
Number of Industries 4;
Total Number of Facilities 451;
Number of Occupations 3;
Total Number of Employees Exposed 2,020
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M3031;
Number of Industries 2;
Total Number of Facilities 661;
Number of Occupations 5;
Total Number of Employees Exposed 5,132;
Total Number of Female Employees Exposed 2,765


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62. Discontinued.

Used as a biological stain

RTECS Compound Description:
   Mutagen

ALT CAS #: 959-03-5
ALT CAS #: 8000-86-0
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