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| UPDATE: February 2009 | MW: 386.61 | MF: C21H26N2OS2 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
|
ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
N/R
|
N/R
|
N/R
|
N/R
|
| |||
REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
|
| |||
TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
|
| |||
ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
intramuscular | rat
lethal dose (50 percent kill): 509 mg/kg
|
N/R
|
TXAPA9 19,363,1971
|
intramuscular | rabbit
lethal dose (50 percent kill): 405 mg/kg
|
N/R
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TXAPA9 19,363,1971
|
intravenous | mouse
lethal dose (50 percent kill): 26 mg/kg
|
N/R
|
27ZQAG -,29,1972
|
oral | human
lowest published lethal dose: 42 mg/kg
|
Vascular: Regional or general arteriolar or venous dilation | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Blood: Hemorrhage
ARGPAQ 34,955,1977
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oral | man
lowest published toxic dose: 86 mg/kg
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Cardiac: Arrythmias (indlucing changes in conduction)
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JCPYDR 2,222,1982
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oral | mouse
lethal dose (50 percent kill): 560 mg/kg
|
N/R
|
27ZQAG -,29,1972
|
oral | rat
lethal dose (50 percent kill): 644 mg/kg
|
N/R
|
TXAPA9 19,363,1971
|
oral | rabbit
lowest published lethal dose: 800 mg/kg
|
N/R
|
TXAPA9 19,363,1971
|
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
oral | dog
lowest published toxic dose: 60,480 mg/kg/72 week- intermittent
|
Brain and Coverings: Recordings from specific areas of CNS | Skin: After systemic exposure: Dermatitis, other Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 19,363,1971
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REVIEWS:
ORGANIZATION
|
STANDARD
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REFERENCE
TOXICOLOGY REVIEW
|
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JTCTDW 38,615,2000
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TOXICOLOGY REVIEW
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MUREAV 488,151,2001
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TOXICOLOGY REVIEW
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JOPSEQ 19,16,2005
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TOXICOLOGY REVIEW
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JEMME* 31,53,2006
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TOXICOLOGY REVIEW
|
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EJPHAZ 553,1,2006
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TOXICOLOGY REVIEW
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PSBUL* 35,89,2001
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TOXICOLOGY REVIEW
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PSBUL* 35,66,2001
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STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
N/R
|
N/R
|
N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
|
STANDARD or SURVEY
|
|
REFERENCE
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: X4738 |
 ;Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 103; Total Number of Female Employees Exposed 52 | |||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
N/R
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REFERENCES:
CODEN
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REFERENCE
27ZQAG
|
"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington,
DC, 1972
|
ARGPAQ
|
Archives of General Psychiatry. (AMA, 535 N. Dearborn St., Chicago,IL 60610) V.3- 1960-
|
EJPHAZ
|
European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam,
Netherlands) V.1- 1967-
|
JCPYDR
|
Journal of Clinical Pyschopharmacology. (Williams & Wilkins Co., 428 E. Preston St.,
Baltimore, MD 21202) V.1- 1981-
|
JEMME*
|
The Journal of emergency medicine (New York : Pergamon Press) V.1- 1983-
|
JOPSEQ
|
Journal of Psychopharmacology (Oxford). (Oxford University Press, Great Clarendon St., Oxford
OX2 6DP, UK) V.1- 1987-
|
JTCTDW
|
Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY
10016) V.19- 1982-
|
MUREAV
|
Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
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PSBUL*
|
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TXAPA9
|
Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1959-
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