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Phenothiazine, 10 - (2 - (dimethylamino) propyl) - , monohydrochloride

RTECS #: SO8225000

CAS #: 58-33-3

UPDATE: November 2008 MW: 320.91 MF: C17H20N2S•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 10 - (2 - (Dimethylamino) propyl) phenothiazine monohydrochloride
  2. 10 - (2 - Dimethylaminopropyl) phenothiazine hydrochloride
  3. 10 - (2 - Dimethylamino - 1 - propyl) phenothiazine hydrochloride
  4. 10 - (3 - Dimethylaminoisopropyl) phenothiazine hydrochloride
  5. 10H - Phenothiazine - 10 - ethanamine, N,N,alpha - trimethyl - , monohydrochloride
  6. Atosil
  7. Diprasine
  8. Diprazin
  9. Dorme
  10. Fellozine
  11. Fenergan
  12. Ganphen
  13. HL 8700
  14. Kinetosin
  15. N - (2' - Dimethylamino - 2' - methyl) ethylphenothiazine hydrochloride
  1. N - (2 - Dimethylaminopropyl - 1) phenothiazine hydrochloride
  2. Phencen
  3. Phenergan hydrochloride
  4. Pipolfen
  5. Plletia
  6. Primine
  7. Promantine
  8. Promethiazin (German)
  9. Promethazine hydrochloride
  10. Promethazine N - (2' - dimethylamino - 2' - methylethyl) phenothiazine hydrochloride
  11. Promine
  12. Pyrethia
  13. Remsed
  14. Romegran hydrochloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 60 mg/kg (5-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) RCOCB8 7,701,1974
oral
rat 		lowest published toxic dose: 240 mg/kg (5-16 day pregnant) Reproductive: Effects on fertility: Other measures of fertility RCOCB8 7,701,1974
parenteral
rat 		lowest published toxic dose: 350 mg/kg (1 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		FATOAO 48,89,1985
parenteral
rat 		lowest published toxic dose: 350 mg/kg (2 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FATOAO 48,89,1985
parenteral
rat 		lowest published toxic dose: 350 mg/kg (3 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		FATOAO 48,89,1985
parenteral
rat 		lowest published toxic dose: 350 mg/kg (4 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		FATOAO 48,89,1985
parenteral
rat 		lowest published toxic dose: 350 mg/kg (5 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		FATOAO 48,89,1985
parenteral
rat 		lowest published toxic dose: 350 mg/kg (6 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FATOAO 48,89,1985
parenteral
rat 		lowest published toxic dose: 350 mg/kg (7 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FATOAO 48,89,1985
parenteral
rat 		lowest published toxic dose: 350 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FATOAO 48,89,1985
parenteral
rat 		lowest published toxic dose: 350 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FATOAO 48,89,1985
parenteral
rat 		lowest published toxic dose: 350 mg/kg (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Abortion

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) 		FATOAO 48,89,1985
parenteral
rat 		lowest published toxic dose: 350 mg/kg (11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Abortion

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) 		FATOAO 48,89,1985
parenteral
rat 		lowest published toxic dose: 350 mg/kg (12 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Abortion

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) 		FATOAO 48,89,1985
parenteral
rat 		lowest published toxic dose: 350 mg/kg (13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Abortion

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) 		FATOAO 48,89,1985
parenteral
rat 		lowest published toxic dose: 350 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FATOAO 48,89,1985
parenteral
rat 		lowest published toxic dose: 350 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FATOAO 48,89,1985
parenteral
rat 		lowest published toxic dose: 350 mg/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FATOAO 48,89,1985
parenteral
rat 		lowest published toxic dose: 350 mg/kg (13 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FATOAO 48,89,1985
parenteral
rat 		lowest published toxic dose: 350 mg/kg (14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FATOAO 48,89,1985
parenteral
rat 		lowest published toxic dose: 350 mg/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FATOAO 48,89,1985


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 35 mg/kg N/R PHARAT 38,749,1983
intraperitoneal
mouse 		lethal dose (50 percent kill): 160 mg/kg N/R CKFRAY 15,526,1966
intraperitoneal
rat 		lethal dose (50 percent kill): 170 mg/kg N/R CKFRAY 15,526,1966
intraperitoneal
rat 		lowest published toxic dose: 5 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TOXIA6 45,585,2005
intravenous
guinea pig 		lethal dose (50 percent kill): 42,500 µg/kg N/R AIPTAK 113,313,1958
intravenous
mouse 		lethal dose (50 percent kill): 50 mg/kg N/R JPETAB 108,340,1953
intravenous
rat 		lethal dose (50 percent kill): 15 mg/kg N/R YAKUD5 22,375,1980
oral
child 		lowest published toxic dose: 20 mg/kg Behavioral: Excitement

Behavioral: Change in motor activity (specific assay)

Behavioral: Stiffness 		LANCAO 1,368,1980
oral
human 		lowest published toxic dose: 3,500 µg/kg/ day Behavioral: Sleep

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Rigidity (includes catalepsy) 		AJPSAO 113,654,1957
oral
mouse 		lethal dose (50 percent kill): 255 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes 		AIPTAK 135,364,1962
parenteral
rat 		lethal dose (50 percent kill): 525 mg/kg N/R FATOAO 48,89,1985
subcutaneous
dog 		lethal dose (50 percent kill): 250 mg/kg N/R NYKZAU 54,688,1958
subcutaneous
mouse 		lethal dose (50 percent kill): 240 mg/kg N/R YAKUD5 22,375,1980
subcutaneous
rat 		lethal dose (50 percent kill): 400 mg/kg N/R YAKUD5 22,375,1980
subcutaneous
rat 		lowest published toxic dose: 5.66 mg/kg Behavioral: Anticonvulsant EKFAE9 62,55,1999
subcutaneous
rat 		lowest published toxic dose: 1 mg/kg Immunological Including Allergic: Decreased immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		JPHSC* 101,350,2006


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rabbit 		lowest published toxic dose: 25 mg/kg/5 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		JEPOEC 16,51,1997
oral
mouse 		lowest published toxic dose: 900 mg/kg/16 day- intermittent Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-425,1993
oral
mouse 		lowest published toxic dose: 2,925 mg/kg/13 week- intermittent Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-425,1993
oral
rat 		lowest published toxic dose: 666 mg/kg/16 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-425,1993
oral
rat 		lowest published toxic dose: 2,164 mg/kg/13 week- intermittent Olfaction: Other olfaction effects

Liver: Changes in liver weight 		NTPTR* NTP-TR-425,1993
oral
rat 		lowest published toxic dose: 17,149.5 mg/kg/103 week- intermittent Brain and Coverings: Tumors

Endocrine: Adrenal cortex tumors

Tumorigenic: Active as anti-cancer agent 		NTIS** PB94-210192
oral
rat 		lowest published toxic dose: 17,149.5 mg/kg/103 week- intermittent Reproductive: Tumorigenic effects: Uterine tumors

Tumorigenic: Active as anti-cancer agent 		NTIS** PB94-210192


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 578,88,2005
TOXICOLOGY REVIEW
JEMME* 31,53,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81480;
Number of Industries 2;
Total Number of Facilities 946;
Number of Occupations 5;
Total Number of Employees Exposed 7,809
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81480;
Number of Industries 1;
Total Number of Facilities 292;
Number of Occupations 4;
Total Number of Employees Exposed 8,796;
Total Number of Female Employees Exposed 7,472


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an antihistamine
NCI Carcinogenesis Studies (gavage);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921-
CKFRAY Cesko-Slovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1-42, 1952-93. For publisher information, see CSLFEK
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
JEMME* The Journal of emergency medicine (New York : Pergamon Press) V.1- 1983-
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPHSC*
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946-
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used as an antihistamine

FDA-over the counter and proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Reproductive Effector
   Human Data

ALT CAS #: 16639-38-6
 Click Here for Additional Information about RTECS

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