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Phenothiazine, 10 - (3 - (dimethylamino) propyl) -

RTECS #: SO7000000

CAS #: 58-40-2

UPDATE: May 2009 MW: 284.45 MF: C17H20N2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 10 - (3 - (Dimethylamino) propyl) phenothiazine
  2. 10H - Phenothiazine - 10 - propanamine, N,N - dimethyl -
  3. 3276 RP
  4. A 145
  5. Ampazine
  6. Berophen
  7. Esparin
  8. Liranol
  9. Neo - Hibernex
  10. Prazin
  11. Prazine
  1. Promazin
  2. Promazina (Italian)
  3. Promazine
  4. Promwill
  5. Protactyl
  6. RP 3276
  7. Romtiazin
  8. Sinophenin
  9. Tomil
  10. Verophen
  11. WY 1094


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 80 mg/kg (1-18 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JNEUAY 3,295,1962
unreported route
mouse 		lowest published toxic dose: 4 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility FESTAS 12,346,1961


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 140 mg/kg Autonomic Nervous System: Smooth muscle relaxant (mechanism undefined, spasmolytic) AIPTAK 155,69,1965
intraperitoneal
rat 		lowest published lethal dose: 210 mg/kg N/R TXAPA9 1,156,1959
intravenous
mouse 		lethal dose (50 percent kill): 45 mg/kg Behavioral: Sleep APTOA6 19,87,1962
intravenous
rat 		lethal dose (50 percent kill): 14,500 µg/kg Eye: Changes in circulation

Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea 		AIPTAK 119,311,1959
intravenous
rabbit 		lethal dose (50 percent kill): 21 mg/kg N/R AIPTAK 120,450,1959
oral
mouse 		lethal dose (50 percent kill): 401 mg/kg Behavioral: Somnolence (general depressed activity) ARZNAD 8,489,1958
oral
rat 		lethal dose (50 percent kill): 350 mg/kg N/R ARZNAD 8,507,1958
subcutaneous
mouse 		lethal dose (50 percent kill): 110 mg/kg Eye: Ptosis

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor 		ARZNAD 24,1798,1974
subcutaneous
rat 		lethal dose (50 percent kill): 192 mg/kg Eye: Ptosis

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor 		ARZNAD 24,1798,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 2,000 mg/kg/4 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		TOXID9 12,476,2008


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
IDPYAK 1,203,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6079;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 2;
Total Number of Employees Exposed 628;
Total Number of Female Employees Exposed 314


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950-
IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued.
JNEUAY Journal of Neuropsychiatry. (Chicago, IL) V.1-5, 1959-64. For publisher information, see BENPBG.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector

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