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Phenothiazine, 10 - (3 - (dimethylamino) - 2 - methylpropyl) - 2 - methoxy - , ( - ) -

RTECS #: SO6125000

CAS #: 60-99-1

UPDATE: May 2009 MW: 328.51 MF: C19H24N2OS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. REFERENCES:

SYNONYMS:

  1. ( - ) - 10 - (3 - (Dimethylamino) - 2 - methylpropyl) - 2 - methoxyphenothiazine
  2. 10H - Phenothiazine - 10 - propanamine, 2 - methoxy - N,N,beta - trimethyl - , (R) -
  3. Arc - VI - C - 5
  4. Bayer 1213
  5. CL 36467
  6. CL 39743
  7. CL 53212
  8. Dedoran
  9. Hirnamine
  10. Levomepromazine
  11. Levopromazine
  12. Levopromazioni
  1. Levotomin
  2. Methoxytrimeprazine
  3. Milezin
  4. Minozinan
  5. Nirnamine
  6. Nirvan
  7. Nomizan
  8. RP 7044
  9. SKF 5116
  10. Sinogan
  11. Sinogan - debil
  12. Tisercin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 2 mg/kg Behavioral: Anticonvulsant FATOAO 53,19,1990
intraperitoneal
mouse 		lethal dose (50 percent kill): 58.5 mg/kg N/R FATOAO 53,19,1990
intravenous
mouse 		lethal dose (50 percent kill): 39 mg/kg N/R PSDTAP 9,159,1968
oral
wild bird 		lethal dose (50 percent kill): 100 mg/kg N/R TXAPA9 21,315,1972
oral
man 		lowest published toxic dose: 7,143 µg/kg Blood: Thrombocytopenia HUPSEC 9,299,1994
oral
mouse 		lethal dose (50 percent kill): 370 mg/kg N/R ARZNAD 15,841,1965
oral
mouse 		lowest published toxic dose: 10 mg/kg Behavioral: Change in motor activity (specific assay) NEROEW 23,375,2000
oral
rat 		lethal dose (50 percent kill): 1,100 mg/kg N/R 27ZQAG -,31,1972
subcutaneous
mouse 		lethal dose (50 percent kill): 300 mg/kg N/R PSCBAY 2,17,1963
subcutaneous
rat 		lethal dose (50 percent kill): 45 mg/kg N/R 27ZQAG -,31,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rabbit 		: 276 mg/kg/92 day- intermittent Cardiac: Other changes ETPAEK 57,207,2006
intraperitoneal
rat 		lowest published toxic dose: 70 mg/kg/2 week- intermittent Behavioral: Tolerance FATOAO 44,151,1981
oral
dog 		lowest published toxic dose: 7,200 mg/kg/90 day- intermittent Brain and Coverings: Recordings from specific areas of CNS

Cardiac: EKG changes not diagnostic of above

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 8,349,1966
oral
dog 		lowest published toxic dose: 15 gm/kg/75 day- intermittent Vascular: BP lowering not characterized in autonomic section

Kidney, Ureter, and Bladder: Hematuria

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 8,349,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
JMSCA9 106,755,1960
TOXICOLOGY REVIEW
IDPYAK 1,203,1974
TOXICOLOGY REVIEW
TJADAB 15,57,1977
TOXICOLOGY REVIEW
HUTOX* -,281,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena, Postfach 100537, D-07705 Jena, Germany) V.44- 1992-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
HUPSEC Human Psychopharmacology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W.Sussex PO19 1UD, United Kingdom) V.1- 1986-
HUTOX*
IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued.
JMSCA9 Journal of Mental Science. (London, UK) V.4-108, 1857-1962. For publisher information, see BJPYAJ.
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987-
PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9.
PSDTAP Proceedings of the European Society for the Study of Drug Toxicity. (Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see PESTD5.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a neuroleptic

RTECS Compound Description:
   Drug
   Human Data

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