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Phenothiazine, 10 - (2 - (diethylamino) propyl) -

RTECS #: SO4900000

CAS #: 522-00-9

UPDATE: May 2009 MW: 312.51 MF: C19H24N2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. REFERENCES:

SYNONYMS:

  1. (+ - ) - Ethopropazine
  2. (+ - ) - Profenamine
  3. 10 - (2 - Diethylaminopropyl) phenothiazine
  4. 10H - Phenothiazine - 10 - ethanamine, N,N - diethyl - alpha - methyl -
  5. 2 - Diethylamino - 1 - propyl - N - dibenzoparathiazine
  6. Ethopromazine
  7. Ethopropazine
  8. Isothazine
  9. Isothiazine
  10. N,N - Diethyl - alpha - methyl - 10H - phenothiazine - 10 - ethanamine
  11. Parfezine
  12. Parkin
  13. Parsidol
  1. Parsitan
  2. Parsotil
  3. Phenopropazine
  4. Profenamina (Italian)
  5. Profenamine
  6. Profenaminum
  7. Prophenamine
  8. Prophenaminum
  9. RP 3356
  10. Rodipal
  11. SC 2538
  12. SKF 2538
  13. W 483


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
mouse 		lethal dose (50 percent kill): 50 mg/kg N/R 27ZQAG -,41,1972
intravenous
rat 		lethal dose (50 percent kill): 15 mg/kg N/R 27ZQAG -,41,1972
intravenous
rabbit 		lethal dose (50 percent kill): 15 mg/kg N/R 27ZQAG -,41,1972
oral
mouse 		lethal dose (50 percent kill): 300 mg/kg N/R BCFAAI 111,293,1972
subcutaneous
mouse 		lethal dose (50 percent kill): 500 mg/kg N/R 27ZQAG -,41,1972
subcutaneous
rat 		lethal dose (50 percent kill): 200 mg/kg N/R PSCBAY 2,17,1963
subcutaneous
rabbit 		lethal dose (50 percent kill): 200 mg/kg N/R 27ZQAG -,41,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
HUTOX* -,281,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7007;
Number of Industries 1;
Total Number of Facilities 16;
Number of Occupations 1;
Total Number of Employees Exposed 94;
Total Number of Female Employees Exposed 62


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894-
HUTOX*
PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9.

Used as an antiparkinsonian and anticholinergic agent

RTECS Compound Description:
   Drug

ALT CAS #: 37342-22-6
ALT CAS #: 115016-98-3
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