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Phenothiazine, 2 - chloro - 10 - (3 - (4 - methyl - 1 - piperazinyl) propyl) -

RTECS #: SO2700000

CAS #: 58-38-8

UPDATE: May 2009 MW: 373.98 MF: C20H24ClN3S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. 10H - Phenothiazine, 2 - chloro - 10 - (3 - (4 - methyl - 1 - piperazinyl) propyl) -
  2. 2 - Chloro - 10 - (3 - (4 - methyl - 1 - piperazinyl) propyl) phenothiazine
  3. 3 - Chloro - 10 - (3 - (1 - methyl - 4 - piperazinyl) propyl) phenothiazine
  4. 6140 RP
  5. Bayer A 173
  6. Capazine
  7. Chloro - 3 (N - methylpiperazinyl - 3 propyl) - 10 phenothiazine (French)
  8. Chlorperazine
  9. Emelent
  10. Kronocin
  1. Meterazine
  2. N - (gamma - (4' - Methylpiperazinyl - 1') propyl) - 3 - chlorophenothiazine
  3. Nipodal
  4. Prochlorperazine
  5. Prochlorpromazine
  6. SKF 4657
  7. Stemetil
  8. Tementil
  9. Temetid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 100 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death CAJPBD 3,2,1963
parenteral
rat 		lowest published toxic dose: 80 mg/kg (1-8 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) 15QWAW -,290,1965
subcutaneous
rat 		lowest published toxic dose: 20,400 µg/kg (51 day prior to copulation) Reproductive: Effects on newborn: Behavioral PSYPAG 16,5,1969
unreported route
mouse 		lowest published toxic dose: 4 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility FESTAS 12,346,1961


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
human 		lowest published toxic dose: 0.14 mg/kg Behavioral: Analgesia AEMME* 8,873,2001
intraperitoneal
mouse 		lethal dose (50 percent kill): 120 mg/kg N/R CRSBAW 152,1371,1958
intraperitoneal
mouse 		lowest published toxic dose: 0.5 mg/kg Behavioral: Analgesia BJMRDK 38,469,2005
intraperitoneal
rat 		lethal dose (50 percent kill): 400 mg/kg N/R FATOAO 24,136,1961
intravenous
dog 		lowest published lethal dose: 100 mg/kg N/R 27ZIAQ -,213,1973
intravenous
human 		lowest published toxic dose: 0.14 mg/kg Behavioral: Analgesia AEMME* 8,873,2001
intravenous
mouse 		lethal dose (50 percent kill): 85 mg/kg N/R CKFRAY 16,255,1967
intravenous
rat 		lethal dose (50 percent kill): >20 mg/kg N/R AIPTAK 120,450,1959
intravenous
rabbit 		lethal dose (50 percent kill): >5 mg/kg N/R AIPTAK 120,450,1959
multiple
woman 		lowest published toxic dose: 800 µg/kg/4 day- intermittent Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Nausea or vomiting 		AIMEAS 52,538,1960
oral
child 		lowest published toxic dose: 2 mg/kg/24 hour- intermittent Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) AEMED3 30,234,1997
oral
dog 		lowest published lethal dose: 102 mg/kg N/R 27ZIAQ -,213,1973
oral
human 		lowest published toxic dose: 560 µg/kg/10 hour- intermittent Behavioral: Headache

Vascular: BP elevation not characterized in autonomic section 		NEJMAG 312,1125,1985
oral
mouse 		lethal dose (50 percent kill): 400 mg/kg N/R NIIRDN 6,722,1982
oral
rat 		lethal dose (50 percent kill): 1,800 mg/kg N/R 27ZIAQ -,213,1973
oral
woman 		lowest published toxic dose: 4,500 µg/kg/3 day- intermittent Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		BJCPAT 28,201,1974
subcutaneous
mouse 		lethal dose (50 percent kill): 350 mg/kg N/R PSYPAG 2,209,1961
unreported route
woman 		lowest published toxic dose: 1,800 µg/kg/2 day- intermittent Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Cyanosis

Kidney, Ureter, and Bladder: Urine volume decreased or anuria 		AIMEAS 52,538,1960


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
JMSCA9 106,755,1960
TOXICOLOGY REVIEW
IDPYAK 1,203,1974
TOXICOLOGY REVIEW
ADVPA3 4,263,1966
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
EJPHAZ 553,1,2006
TOXICOLOGY REVIEW
HUTOX* -,281,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1048;
Number of Industries 1;
Total Number of Facilities 58;
Number of Occupations 2;
Total Number of Employees Exposed 230
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1048;
Number of Industries 1;
Total Number of Facilities 134;
Number of Occupations 4;
Total Number of Employees Exposed 7,332;
Total Number of Female Employees Exposed 6,544


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
15QWAW "Agents Affecting Fertility, a Symposium, 1964," Austin, C.R., and J.S. Perry, eds., Boston, Little, Brown & Co., 1965
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ.
AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038)
AEMME* Academic emergency medicine: official journal of the Society for Academic Emergency Medicine (Philadelphia Pa Hanley And Belfus) V.1- 1994-
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
BJCPAT British Journal of Clinical Practice. (Medical News Group, 1 Bedford St., London WC2E 9HD, UK) V.10(10)- 1956-
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
CAJPBD Proceedings of the Congenital Anomalies Research Association of Japan. (Kyoto, Japan) No.1- 1961-
CKFRAY Cesko-Slovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1-42, 1952-93. For publisher information, see CSLFEK
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950-
HUTOX*
IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued.
JMSCA9 Journal of Mental Science. (London, UK) V.4-108, 1857-1962. For publisher information, see BJPYAJ.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For publisher information, see PSCHDL.

Used as an antiemetic drug

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Reproductive Effector
   Human Data

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