RTECS:SM9275000 The Registry of Toxic Effects of Chemical Substances

Phenol, 2,3,4,6 - tetrachloro -

RTECS #: SM9275000

CAS #: 58-90-2

UPDATE: May 2008 MW: 231.88 MF: C₆H₂Cl₄O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

REPRODUCTIVE EFFECTS DATA:

TUMORIGENIC DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

2,3,4,6 - Tetrachlorophenol

2,4,5,6 - Tetrachlorophenol

Dowicide 6

RCRA waste number U212

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
cytogenetic analysis hamster lung 250 mg/L MUREAV 241,175,1990
DNA damage human fibroblast 0.25 mmol/L/1 hour TOLED5 147,35,2004
mutation in mammalian somatic cells hamster lung 3,500 痢/L CMSHAF 14,1617,1985

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 300 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 28,146,1974

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
subcutaneous
mouse lowest published toxic dose: 100 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors NTIS PB223-159

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE**
intraperitoneal
mouse lethal dose (50 percent kill): 82 mg/kg N/R VCVGK* -,245,1994
intraperitoneal
rat lethal dose (50 percent kill): 130 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature increase BJPCAL 13,20,1958
intraperitoneal
rat lethal dose (50 percent kill): 130 mg/kg N/R VCVGK* -,245,1994
oral
dog lethal dose (50 percent kill): 250 mg/kg N/R VCVGK* -,246,1994
oral
guinea pig lethal dose (50 percent kill): 250 mg/kg N/R FMCHA2 -,C299,1991
oral
gerbil lethal dose (50 percent kill): 698 mg/kg N/R ARTODN 40,63,1978
oral
mouse lethal dose (50 percent kill): 30 mg/kg N/R VCVGK* -,245,1994
oral
rat lethal dose (50 percent kill): 140 mg/kg N/R VCVGK* -,245,1994
oral
rat lowest published toxic dose: 300 mg/kg Gastrointestinal: Other changes

Liver: Change in gall bladder structure or function

Liver: Other changes VCVGK* -,248,1994
subcutaneous
rat lowest published lethal dose: 210 mg/kg N/R HBTXAC 5,129,1959
skin
rat lethal dose (50 percent kill): 485 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness BECTA6 31,680,1983
skin
rat lethal dose (50 percent kill): 485 mg/kg N/R VCVGK* -,245,1994
skin
rat lethal dose (20 percent kill): 2 mg/kg/1 hour N/R VCVGK* -,248,1994
skin
rat lethal dose (10 percent kill): 2 mg/kg/1 hour N/R VCVGK* -,248,1994
skin
rabbit lethal dose (50 percent kill): 250 mg/kg N/R VCVGK* -,245,1994

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 700 mg/kg/7 day- intermittent Liver: Other changes

Gastrointestinal: Other changes

Liver: Change in gall bladder structure or function VCVGK* -,248,1994

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 41,319,1986

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg/m³, short term exposure limit 1.5 mg/m³, Skin, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 0.5 mg/m³;
short term exposure limit 1.5 mg/m³, Skin, JUN2005

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4224;
Number of Industries 6;
Total Number of Facilities 362;
Number of Occupations 17;
Total Number of Employees Exposed 7,168

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as disinfectant and as preservative for wood, latex and leather
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #45

REFERENCES:
CODEN
REFERENCE

ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as disinfectant and as preservative for wood, latex and leather

NOISH PROFILE (CHLOROPHENOLS), SRC, 3/81

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 12698-64-5
Click Here for Additional Information about RTECS

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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
subcutaneous mouse	lowest published toxic dose: 100 mg/kg	Tumorigenic: Carcinogenic by RTECS criteria Blood: Tumors	NTIS** PB223-159

SYNONYMS:
2,3,4,6 - Tetrachlorophenol 2,4,5,6 - Tetrachlorophenol	Dowicide 6 RCRA waste number U212

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
cytogenetic analysis	hamster lung	250 mg/L	MUREAV 241,175,1990
DNA damage	human fibroblast	0.25 mmol/L/1 hour	TOLED5 147,35,2004
mutation in mammalian somatic cells	hamster lung	3,500 痢/L	CMSHAF 14,1617,1985

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 300 mg/kg (6-15 day pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	TXAPA9 28,146,1974

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 82 mg/kg	N/R	VCVGK* -,245,1994
intraperitoneal rat	lethal dose (50 percent kill): 130 mg/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Nutritional and Gross Metabolic: Body temperature increase	BJPCAL 13,20,1958
intraperitoneal rat	lethal dose (50 percent kill): 130 mg/kg	N/R	VCVGK* -,245,1994
oral dog	lethal dose (50 percent kill): 250 mg/kg	N/R	VCVGK* -,246,1994
oral guinea pig	lethal dose (50 percent kill): 250 mg/kg	N/R	FMCHA2 -,C299,1991
oral gerbil	lethal dose (50 percent kill): 698 mg/kg	N/R	ARTODN 40,63,1978
oral mouse	lethal dose (50 percent kill): 30 mg/kg	N/R	VCVGK* -,245,1994
oral rat	lethal dose (50 percent kill): 140 mg/kg	N/R	VCVGK* -,245,1994
oral rat	lowest published toxic dose: 300 mg/kg	Gastrointestinal: Other changes Liver: Change in gall bladder structure or function Liver: Other changes	VCVGK* -,248,1994
subcutaneous rat	lowest published lethal dose: 210 mg/kg	N/R	HBTXAC 5,129,1959
skin rat	lethal dose (50 percent kill): 485 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Behavioral: Muscle weakness	BECTA6 31,680,1983
skin rat	lethal dose (50 percent kill): 485 mg/kg	N/R	VCVGK* -,245,1994
skin rat	lethal dose (20 percent kill): 2 mg/kg/1 hour	N/R	VCVGK* -,248,1994
skin rat	lethal dose (10 percent kill): 2 mg/kg/1 hour	N/R	VCVGK* -,248,1994
skin rabbit	lethal dose (50 percent kill): 250 mg/kg	N/R	VCVGK* -,245,1994

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 700 mg/kg/7 day- intermittent	Liver: Other changes Gastrointestinal: Other changes Liver: Change in gall bladder structure or function	VCVGK* -,248,1994

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review	Human Limited Evidence	IMEMDT 41,319,1986

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Occupational Exposure Limit - FINLAND	time-weighted average 0.5 mg/m³, short term exposure limit 1.5 mg/m³, Skin, JAN1993
Occupational Exposure Limit - SWEDEN	time-weighted average 0.5 mg/m³; short term exposure limit 1.5 mg/m³, Skin, JUN2005

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: M4224; Number of Industries 6; Total Number of Facilities 362; Number of Occupations 17; Total Number of Employees Exposed 7,168

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as disinfectant and as preservative for wood, latex and leather
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #45

REFERENCES:
CODEN	REFERENCE
ARTODN	Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BECTA6	Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BJPCAL	British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
CMSHAF	Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
FMCHA2	Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
HBTXAC	"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
IMEMDT	IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5	Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK*	"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.