RTECS:SL9800000 The Registry of Toxic Effects of Chemical Substances

Phenol, 2,2' - methylenebis (6 - tert - butyl - 4 - ethyl -

RTECS #: SL9800000

CAS #: 88-24-4

UPDATE: February 2008 MW: 368.61 MF: C₂₅H₃₆O₂

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

2,2' - Methylenebis (6 - tert - butyl - 4 - ethylphenol)

2,2' - Methylenebis (4 - ethyl - 6 - tert - butylphenol)

AO 425

Agidol 7

Antage W 500

Antioxidant 425

Bis (2 - hydroxy - 3 - tert - butyl - 5 - ethylphenyl) methane

Chemanox 22

Cyanox 425

Nocrac NS 5

Phenol, 2,2' - methylenebis (6 - (1,1 - dimethylethyl) - 4 - ethyl - (9CI)

Plastanox 425 antioxidant

USAF CY - 6

Yoshinox 425

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
mouse lowest published toxic dose: 24,156 mg/kg (61 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct ARTODN 80,225,2006
oral
rat lowest published toxic dose: 1,250 mg/kg (1-22 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) AJANA2 110,29,1962
oral
rat lowest published toxic dose: 2,946.3 mg/kg (61 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct ARTODN 80,225,2006

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 50 mg/kg N/R NTIS AD277-689
intraperitoneal
rat lethal dose (50 percent kill): >10 gm/kg Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTSCDR 17,135,1992
oral
rat lethal dose (50 percent kill): >10 gm/kg Behavioral: Change in motor activity (specific assay) JTSCDR 17,135,1992

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 80 gm/kg/12 week- continuous Liver: Changes in liver weight

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JTSCDR 17,135,1992
oral
rat lowest published toxic dose: 16,800 mg/kg/4 week- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases JTSCDR 18,49,1993
oral
rat lowest published toxic dose: 32,760 mg/kg/78 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) JJATDK 16,15,1996

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9392;
Number of Industries 3;
Total Number of Facilities 90;
Number of Occupations 4;
Total Number of Employees Exposed 5,106;
Total Number of Female Employees Exposed 2,789

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as nonstaining, nondiscoloring rubber antioxidant with high activity
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

AJANA2 American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1-192, 1901-91.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used as nonstaining, nondiscoloring rubber antioxidant with high activity

RTECS Compound Description:
Reproductive Effector

Click Here for Additional Information about RTECS

NIOSH Home | NIOSH Search | Site Index | Topic List | RTECS List | Contact Us

SYNONYMS:
2,2' - Methylenebis (6 - tert - butyl - 4 - ethylphenol) 2,2' - Methylenebis (4 - ethyl - 6 - tert - butylphenol) AO 425 Agidol 7 Antage W 500 Antioxidant 425 Bis (2 - hydroxy - 3 - tert - butyl - 5 - ethylphenyl) methane	Chemanox 22 Cyanox 425 Nocrac NS 5 Phenol, 2,2' - methylenebis (6 - (1,1 - dimethylethyl) - 4 - ethyl - (9CI) Plastanox 425 antioxidant USAF CY - 6 Yoshinox 425

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral mouse	lowest published toxic dose: 24,156 mg/kg (61 day male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	ARTODN 80,225,2006
oral rat	lowest published toxic dose: 1,250 mg/kg (1-22 day pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	AJANA2 110,29,1962
oral rat	lowest published toxic dose: 2,946.3 mg/kg (61 day male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	ARTODN 80,225,2006

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 50 mg/kg	N/R	NTIS** AD277-689
intraperitoneal rat	lethal dose (50 percent kill): >10 gm/kg	Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JTSCDR 17,135,1992
oral rat	lethal dose (50 percent kill): >10 gm/kg	Behavioral: Change in motor activity (specific assay)	JTSCDR 17,135,1992

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 80 gm/kg/12 week- continuous	Liver: Changes in liver weight Blood: Changes in leukocyte (WBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase	JTSCDR 17,135,1992
oral rat	lowest published toxic dose: 16,800 mg/kg/4 week- continuous	Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases	JTSCDR 18,49,1993
oral rat	lowest published toxic dose: 32,760 mg/kg/78 week- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	JJATDK 16,15,1996

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X9392; Number of Industries 3; Total Number of Facilities 90; Number of Occupations 4; Total Number of Employees Exposed 5,106; Total Number of Female Employees Exposed 2,789

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as nonstaining, nondiscoloring rubber antioxidant with high activity
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
AJANA2	American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1-192, 1901-91.
ARTODN	Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
JJATDK	JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JTSCDR	Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.