RTECS:SK7600000 The Registry of Toxic Effects of Chemical Substances

Phenol, 2,4 - diamino - , dihydrochloride

RTECS #: SK7600000

CAS #: 137-09-7

UPDATE: February 2003 MW: 197.08 MF: C₆H₈N₂O•2ClH

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

TUMORIGENIC DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

2,4 - Diaminophenol dihydrochloride

2,4 - Diaminophenol hydrochloride

Acrol

Amidol

Dianol

NCI - C60026

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 330 ng/plate (-enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in mammalian somatic cells mouse lymphocyte 2 mg/L ENMUDM 9,143,1987

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
mouse lowest published toxic dose: 19,570 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors NTIS PB93-117919

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lowest published lethal dose: 50 mg/kg N/R RBPMAZ 22,1,1952
oral
rat lethal dose (50 percent kill): 240 mg/kg Eye: Ptosis

Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea JACTDZ 13,330,1994

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE**
oral
mouse lowest published toxic dose: 800 mg/kg/16 day- intermittent Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-401,1992
oral
mouse lowest published toxic dose: 325 mg/kg/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-401,1992
oral
rat lowest published toxic dose: 6,500 mg/kg/13 week- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-401,1992
oral
rat lowest published toxic dose: 800 mg/kg/4 day- intermittent Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS OTS0555385

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2516;
Number of Industries 1;
Total Number of Facilities 809;
Number of Occupations 1;
Total Number of Employees Exposed 6,638;
Total Number of Female Employees Exposed 4,211

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE**

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as hair colorant in oxidative hair dyes
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, PROPOSED RULE FEREAC 47,27009,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis Studies (gavage);some evidence:mouse NTPTR* NTP-TR-401,1992
NCI Carcinogenesis Studies (gavage);equivocal evidence:mouse
NCI Carcinogenesis Studies (gavage);no evidence:rat

REFERENCES:
CODEN
REFERENCE

ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RBPMAZ Revue Belge de Pathologie et de Medecine Experimentale. (Brussels, Belgium) V.18-31, 1947-65. For publisher information, see PTEUA6.

Used as hair colorant in oxidative hair dyes

RTECS Compound Description:
Tumorigen
Mutagen

Click Here for Additional Information about RTECS

NIOSH Home | NIOSH Search | Site Index | Topic List | Contact Us

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral mouse	lowest published toxic dose: 19,570 mg/kg/103 week- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors	NTIS** PB93-117919

SYNONYMS:
2,4 - Diaminophenol dihydrochloride 2,4 - Diaminophenol hydrochloride Acrol	Amidol Dianol NCI - C60026

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
mutation in microorganisms	Salmonella typhimurium	330 ng/plate (-enzymatic activation step)	ENMUDM 5(Suppl 1),3,1983
mutation in mammalian somatic cells	mouse lymphocyte	2 mg/L	ENMUDM 9,143,1987

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lowest published lethal dose: 50 mg/kg	N/R	RBPMAZ 22,1,1952
oral rat	lethal dose (50 percent kill): 240 mg/kg	Eye: Ptosis Behavioral: Ataxia Gastrointestinal: Hypermotility, diarrhea	JACTDZ 13,330,1994

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral mouse	lowest published toxic dose: 800 mg/kg/16 day- intermittent	Liver: Changes in liver weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-401,1992
oral mouse	lowest published toxic dose: 325 mg/kg/13 week- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-401,1992
oral rat	lowest published toxic dose: 6,500 mg/kg/13 week- intermittent	Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-401,1992
oral rat	lowest published toxic dose: 800 mg/kg/4 day- intermittent	Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0555385

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X2516; Number of Industries 1; Total Number of Facilities 809; Number of Occupations 1; Total Number of Employees Exposed 6,638; Total Number of Female Employees Exposed 4,211

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as hair colorant in oxidative hair dyes
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, PROPOSED RULE	FEREAC 47,27009,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis Studies (gavage);some evidence:mouse	NTPTR* NTP-TR-401,1992
NCI Carcinogenesis Studies (gavage);equivocal evidence:mouse
NCI Carcinogenesis Studies (gavage);no evidence:rat

REFERENCES:
CODEN	REFERENCE
ENMUDM	Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FEREAC	Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JACTDZ	Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR*	National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RBPMAZ	Revue Belge de Pathologie et de Medecine Experimentale. (Brussels, Belgium) V.18-31, 1947-65. For publisher information, see PTEUA6.