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Phenol, 4 - allyl - 2 - methoxy -

RTECS #: SJ4375000

CAS #: 97-53-0

UPDATE: November 2008 MW: 164.22 MF: C10H12O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,3,4 - Eugenol
  2. 1 - Hydroxy - 2 - methoxy - 4 - allylbenzene
  3. 1 - Hydroxy - 2 - methoxy - 4 - prop - 2 - enylbenzene
  4. 2 - Methoxy - 4 - allylphenol
  5. 2 - Methoxy - 1 - hydroxy - 4 - allylbenzene
  6. 2 - Methoxy - 4 - prop - 2 - enylphenol
  7. 2 - Methoxy - 4 - (2 - propenyl) phenol
  8. 2 - Metoksy - 4 - allilofenol (Polish)
  9. 4 - Allylcatechol - 2 - methyl ether
  10. 4 - Allylguaiacol
  11. 4 - Allyl - 1 - hydroxy - 2 - methoxybenzene
  12. 4 - Allyl - 2 - methoxyphenol
  1. 4 - Hydroxy - 3 - methoxyallylbenzene
  2. Caryophyllic acid
  3. Eugenic acid
  4. Eugenol
  5. FA 100
  6. FEMA No. 2467
  7. NCI - C50453
  8. Phenol, 2 - methoxy - 4 - (2 - propenyl) -
  9. Synthetic eugenol
  10. p - Allylguaiacol
  11. p - Eugenol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
guinea pig 		100 mg/24 hour moderate CTOIDG 94(8),41,1979
skin
human 		40 mg/48 hour mild FCTXAV 13,545,1975
skin
man 		16 mg/48 hour moderate CTOIDG 94(8),41,1979
skin
pig 		50 mg/48 hour mild CTOIDG 94(8),41,1979
skin
rabbit 		100 mg/24 hour severe CTOIDG 94(8),41,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster fibroblast 125 mg/L FCTOD7 22,623,1984
cytogenetic analysis hamster ovary 300 mg/L EMMUEG 10(Suppl 10),1,1987
cytogenetic analysis human lymphocyte 170 mg/L/24 hour MUREAV 537,117,2003
cytogenetic analysis human other cell types 100 µmol/L/30 hour MUREAV 650,39,2008
DNA damage rat liver 50 µmol/L MUREAV 368,59,1996
unscheduled DNA synthesis hamster embryo 1 ppm SHIGAZ 74,1365,1987
mutation in microorganisms Salmonella typhimurium 50 µg/plate (-enzymatic activation step) NTIS** AD-A116-715
micronucleus test intraperitoneal
mouse 		296 mg/kg/24 hour JOPHBO 15,450,1986
micronucleus test oral
mouse 		29,589 mg/kg/24 hour JOPHBO 15,450,1986
gene conversion and mitotic recombination Saccharomyes cerevisiae 2,270 µmol/L MUREAV 224,427,1989
mutation in mammalian somatic cells mouse lymphocyte 21,300 µg/L SCIEAS 236,933,1987
morphological transform hamster embryo 3 ppm SHIGAZ 74,1365,1987
other mutation test systems hamster ovary 400 mg/L CALEDQ 14,251,1981
sister chromatid exchange hamster ovary 75 mg/L EMMUEG 10(Suppl 10),1,1987
sister chromatid exchange hamster embryo 300 ppb SHIGAZ 74,1365,1987
specific locus test oral
Drosophila melanogaster 		1 mmol/L/48 hour- continuous MUREAV 582,87,2005


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 37,080 mg/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		NTPTR* NTP-TR-223,1983
oral
mouse 		lowest published toxic dose: 259,560 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** PB84-186402
oral
mouse 		lowest published toxic dose: 519,120 mg/kg/103 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		NTIS** PB84-186402


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration : >2,580 mg/m3/4 hour Behavioral: Somnolence (general depressed activity) ARTODN 62,381,1988
intraperitoneal
mouse 		lethal dose (50 percent kill): 500 mg/kg N/R COREAF 250,1148,1960
intraperitoneal
mouse 		lowest published toxic dose: 30 mg/kg Behavioral: Analgesia INJPD2 38,341,2006
intraperitoneal
mouse 		lowest published toxic dose: 100 mg/kg Behavioral: Ataxia

Behavioral: Analgesia 		INJPD2 38,341,2006
intraperitoneal
rat 		lowest published lethal dose: 800 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Kidney, Ureter, and Bladder: Other changes 		RMSRA6 16,449,1896
intraspinal
rat 		lowest published toxic dose: 10 mg/kg Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section 		JOETD7 45,183,1995
intratracheal
hamster 		lethal dose (50 percent kill): 17 mg/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion 		ARTODN 59,78,1986
intratracheal
rat 		lethal dose (50 percent kill): 11 mg/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion 		ARTODN 59,78,1986
intravenous
mouse 		lethal dose (50 percent kill): 72 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory stimulation 		AIPTAK 164,30,1966
intravenous
rat 		lowest published toxic dose: 10 mg/kg Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section 		JOETD7 45,183,1995
oral
dog 		lowest published lethal dose: 500 mg/kg Behavioral: Ataxia

Gastrointestinal: Nausea or vomiting 		GASTAB 15,481,1950
oral
dog 		lowest published toxic dose: 250 mg/kg Gastrointestinal: Nausea or vomiting VCVGK* -,301,1994
oral
dog 		lowest published lethal dose: 500 mg/kg N/R VCVGK* -,301,1994
oral
guinea pig 		lethal dose (50 percent kill): 2,130 mg/kg Behavioral: Somnolence (general depressed activity) FCTXAV 2,327,1964
oral
mouse 		lethal dose (50 percent kill): 3 gm/kg Behavioral: Somnolence (general depressed activity) FCTXAV 2,327,1964
oral
rat 		lethal dose (50 percent kill): 1,930 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea 		PSEBAA 73,148,1950
oral
rat 		lethal dose (50 percent kill): 1,930 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Kidney, Ureter, and Bladder: Hematuria 		VCVGK* -,301,1994
subcutaneous
rat 		lowest published lethal dose: 5 gm/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Kidney, Ureter, and Bladder: Other changes 		RMSRA6 16,449,1896


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 84 gm/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-223,1983
oral
mouse 		lowest published toxic dose: 12.86 gm/kg/26 week- continuous Behavioral: Food intake (animal) JTSCDR 26,129,2001
oral
mouse 		lowest published toxic dose: 131.04 gm/kg/26 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTSCDR 26,129,2001
oral
mouse 		lowest published toxic dose: 750 mg/kg/2 week- intermittent Liver: Other changes CRNGDP 26,689,2005
oral
rat 		lowest published toxic dose: 68 gm/kg/34 day- intermittent Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 7,18,1965
oral
rat 		lowest published toxic dose: 70 gm/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-223,1983
oral
rat 		lowest published toxic dose: 3,580 mg/kg/4 day- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 6,378,1964
oral
rat 		lowest published toxic dose: 858 mg/kg/26 day- intermittent Musculoskeletal: Joints

Musculoskeletal: Other changes 		TCPHP* -,126,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 36,75,1985
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
FCTXAV 13,545,1975
TOXICOLOGY REVIEW
EMMUEG 39,69,2002
TOXICOLOGY REVIEW
MUTAEX 14,5,1999
TOXICOLOGY REVIEW
EMMUEG 43,36,2004
TOXICOLOGY REVIEW
TPHSDY 24,331,2003
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,311,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82100;
Number of Industries 17;
Total Number of Facilities 1,034;
Number of Occupations 31;
Total Number of Employees Exposed 37,569
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82100;
Number of Industries 82;
Total Number of Facilities 9,995;
Number of Occupations 91;
Total Number of Employees Exposed 187,937;
Total Number of Female Employees Exposed 83,766


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: Host-mediated assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a food and feed additive, flavor, packaging material, cosmetic, perfume ingredient
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);equivocal evidence:mouse
NCI Carcinogenesis Studies (feed);no evidence:rat


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GASTAB Gastroenterology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1943-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979-
JOPHBO Journal of Oral Pathology. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1972-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20 Fujimi, Chiyodaku, Tokyo 102, Japan) V.38- 1949-
TCPHP* Toxicology and Clinical Pharmacology of Herbal Products Melanie Johns Cupp ed., Humana press, 2000.
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a food and feed additive, flavor, packaging material, cosmetic, perfume ingredient

FDA-over the counter drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data
   Natural Product
   Primary Irritant

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