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Phenethylamine, o - methoxy - N, alpha - dimethyl - , hydrochloride

RTECS #: SH8050000

CAS #: 5588-10-3

UPDATE: May 2007 MW: 215.75 MF: C11H17NO•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. REFERENCES:

SYNONYMS:

  1. Methoxiphenadrin hydrochloride
  2. Methoxyphenamine hydrochloride
  3. Methoxyphenaminium chloride
  4. N,alpha - Dimethyl - o - methoxy - phenethylamine hydrochloride
  5. Orthoxine hydrochloride
  6. Ortodrinex hydrochloride
  1. Phenethylamine, N,alpha - dimethyl - o - methoxy - , hydrochloride
  2. Proasma hydrochloride
  3. alpha - (2 - Methoxyphenyl) - beta - methylaminopropane hydrochloride
  4. beta - (o - Methoxyphenyl) isopropylmethylamine hydrochloride
  5. o - Methoxy - N,alpha - dimethylphenethylamine hydrochloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 90 mg/kg N/R 27ZQAG -,348,1972
intravenous
rat 		lethal dose (50 percent kill): 50 mg/kg N/R NIIRDN 6,837,1982
intravenous
rabbit 		lethal dose (50 percent kill): 30 mg/kg N/R NIIRDN 6,837,1982
oral
mouse 		lethal dose (50 percent kill): 605 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		NYKZAU 55,653,1959
oral
rat 		lethal dose (50 percent kill): 630 mg/kg N/R NIIRDN 6,837,1982
oral
rabbit 		lethal dose (50 percent kill): 652 mg/kg N/R NIIRDN 6,837,1982
subcutaneous
dog 		lethal dose (50 percent kill): 241 mg/kg N/R NYKZAU 54,688,1958
subcutaneous
mouse 		lethal dose (50 percent kill): 380 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		NYKZAU 55,653,1959
subcutaneous
rat 		lethal dose (50 percent kill): 573 mg/kg N/R NIIRDN 6,837,1982
subcutaneous
rabbit 		lethal dose (50 percent kill): 269 mg/kg N/R NIIRDN 6,837,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 192 mg/kg/27 day- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation

Blood: Changes in leukocyte (WBC) count 		ACPSI* 24,1324,2003
subcutaneous
guinea pig 		lowest published toxic dose: 420 mg/kg/21 day- intermittent Skin: After systemic exposure: Dermatitis, other JPETAB 94,150,1948
subcutaneous
rat 		lowest published toxic dose: 420 mg/kg/21 day- intermittent Skin: After systemic exposure: Dermatitis, other JPETAB 94,150,1948
subcutaneous
rabbit 		lowest published toxic dose: 420 mg/kg/21 day- intermittent Skin: After systemic exposure: Dermatitis, other JPETAB 94,150,1948


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83549;
Number of Industries 4;
Total Number of Facilities 129;
Number of Occupations 2;
Total Number of Employees Exposed 424
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83549;
Number of Industries 1;
Total Number of Facilities 34;
Number of Occupations 2;
Total Number of Employees Exposed 614;
Total Number of Female Employees Exposed 270


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972
ACPSI* Acta pharmacologica Sinica (Shanghai : Shanghai Institute of Materia Medica : Chinese Academy of Science ; Carlton, VIC, Australia : Blackwell Publishing Asia, 2005) V.21- 2000-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-

Used as bronchodilator

FDA-over the counter drug

RTECS Compound Description:
   Drug

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