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Phenazinium, 3,7 - diamino - 2,8 - dimethyl - 5 - phenyl - , chloride

RTECS #: SG1623000

CAS #: 477-73-6

UPDATE: January 1997 MW: 350.88 MF: C20H19N4•Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. 2,8 - Dimethylphenosafranine
  2. Basic Red 2
  3. Brilliant safranine BR
  4. Brilliant safranine G
  5. Brilliant safranine GR
  6. C.I. 50240
  7. C.I. Basic Red 2
  8. Calcozine Red Y
  9. Cerven zasadita 2 (Czech)
  10. Gossypimine
  11. Hidaco safranine
  12. Leather Red HT
  13. Mitsui safranine
  14. Nippon kagaku safranine GK
  15. Nippon kagaku safranine T
  16. Safranin
  17. Safranine
  1. Safranine A
  2. Safranine B
  3. Safranine G
  4. Safranine GF
  5. Safranine J
  6. Safranine O
  7. Safranine OK
  8. Safranine superfine G
  9. Safranine T
  10. Safranine TH
  11. Safranine TN
  12. Safranine Y
  13. Safranine YN
  14. Safranine ZH
  15. Safranin T
  16. Tolusafranine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Bacillus subtilis 2 mg/disc TRENAF 27,153,1976
DNA repair Escherichia coli 4 µg/well ENMUDM 3,429,1981
mutation in microorganisms Salmonella typhimurium 16 µg/plate (+/-enzymatic activation step) TRENAF 27,153,1976


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
mouse 		lethal dose (50 percent kill): 24,020 µg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Lung, Thorax, or Respiration: Other changes 		SMBUA9 9,96,1951
intravenous
rat 		lethal dose (50 percent kill): 28,740 µg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Lung, Thorax, or Respiration: Other changes 		SMBUA9 9,96,1951
intravenous
rabbit 		lethal dose (50 percent kill): 26,940 µg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Lung, Thorax, or Respiration: Other changes 		SMBUA9 9,96,1951
oral
mouse 		lowest published lethal dose: 1,600 mg/kg N/R JPMSAE 69,327,1980


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1441;
Number of Industries 9;
Total Number of Facilities 1,027;
Number of Occupations 18;
Total Number of Employees Exposed 4,314
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1441;
Number of Industries 6;
Total Number of Facilities 1,253;
Number of Occupations 10;
Total Number of Employees Exposed 22,263;
Total Number of Female Employees Exposed 14,330


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62. Discontinued.
TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50-

RTECS Compound Description:
   Mutagen

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