RTECS:SC0175000 The Registry of Toxic Effects of Chemical Substances

tert - Pentyl alcohol

RTECS #: SC0175000

CAS #: 75-85-4

UPDATE: August 2006 MW: 88.17 MF: C₅H₁₂O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

2 - Butanol, 2 - methyl -

2 - Methyl butanol - 2

2 - Methyl - 2 - butanol

3 - Methyl - butanol - (3) (German)

3 - Methylbutan - 3 - ol

Amylene hydrate

Dimethylethylcarbinol

Ethyl dimethyl carbinol

tert - Amyl alcohol

tert - Pentanol

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published lethal concentration: 5,700 ppm/6 hour Behavioral: Somnolence (general depressed activity) NTIS** OTS0536478
intraperitoneal
mouse lowest published lethal dose: 2 gm/kg N/R SAPHAO 79,258,1938
intraperitoneal
rat lethal dose (50 percent kill): 1,000 mg/kg N/R VCVGK* -,108,1984
intraperitoneal
rat lowest published lethal dose: 530 mg/kg N/R VCVGK* -,108,1984
intravenous
mouse lethal dose (50 percent kill): 610 mg/kg N/R AIPTAK 135,330,1962
oral
mouse lowest published lethal dose: 2,500 mg/kg N/R LDTU** -,-,1931
oral
rat lethal dose (50 percent kill): 1 gm/kg Behavioral: Ataxia SCIEAS 116,663,1952
oral
rat lethal dose (50 percent kill): 1,000 mg/kg N/R VCVGK* -,108,1984
oral
rabbit lethal dose (50 percent kill): 2,028 mg/kg Eye: Corneal damage

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Dyspnea IMSUAI 41,31,1972
parenteral
frog lowest published lethal dose: 4 gm/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity) AIPTAK 50,296,1935
rectal
rat lowest published lethal dose: 1,400 mg/kg N/R JPETAB 49,36,1933
subcutaneous
mouse lethal dose (50 percent kill): 2,100 mg/kg N/R VCVGK* -,108,1984
subcutaneous
rat lowest published lethal dose: 1,400 mg/kg N/R VCVGK* -,108,1984
unreported route
man lowest published lethal dose: 441 mg/kg N/R 85DCAI 2,73,1970

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 1,500 ppm/6 hour/7 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases NTIS OTS0536478

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - DENMARK time-weighted average 100 ppm (360 mg/m³), OCT 2002
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m³, MAC(short term exposure limit) 450 mg/m³, JAN1999

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82015;
Number of Industries 6;
Total Number of Facilities 698;
Number of Occupations 8;
Total Number of Employees Exposed 1,949
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82015;
Number of Industries 2;
Total Number of Facilities 10;
Number of Occupations 4;
Total Number of Employees Exposed 57

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a hypnotic agent
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
LDTU "Narkoseversuche mit Hoheren Alkoholen und Stickstoffderivaten, Dissertation," Leube, F., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1931
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SAPHAO Skandinavisches Archiv fuer Physiologie. (Stockholm, Sweden) V.1-83, 1899-1940. For publisher information, see APSCAX.
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a hypnotic agent

RTECS Compound Description:
Human Data

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SYNONYMS:
2 - Butanol, 2 - methyl - 2 - Methyl butanol - 2 2 - Methyl - 2 - butanol 3 - Methyl - butanol - (3) (German) 3 - Methylbutan - 3 - ol	Amylene hydrate Dimethylethylcarbinol Ethyl dimethyl carbinol tert - Amyl alcohol tert - Pentanol

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published lethal concentration: 5,700 ppm/6 hour	Behavioral: Somnolence (general depressed activity)	NTIS** OTS0536478
intraperitoneal mouse	lowest published lethal dose: 2 gm/kg	N/R	SAPHAO 79,258,1938
intraperitoneal rat	lethal dose (50 percent kill): 1,000 mg/kg	N/R	VCVGK* -,108,1984
intraperitoneal rat	lowest published lethal dose: 530 mg/kg	N/R	VCVGK* -,108,1984
intravenous mouse	lethal dose (50 percent kill): 610 mg/kg	N/R	AIPTAK 135,330,1962
oral mouse	lowest published lethal dose: 2,500 mg/kg	N/R	LDTU** -,-,1931
oral rat	lethal dose (50 percent kill): 1 gm/kg	Behavioral: Ataxia	SCIEAS 116,663,1952
oral rat	lethal dose (50 percent kill): 1,000 mg/kg	N/R	VCVGK* -,108,1984
oral rabbit	lethal dose (50 percent kill): 2,028 mg/kg	Eye: Corneal damage Cardiac: Pulse rate decreased with fall in BP Lung, Thorax, or Respiration: Dyspnea	IMSUAI 41,31,1972
parenteral frog	lowest published lethal dose: 4 gm/kg	Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change Behavioral: Somnolence (general depressed activity)	AIPTAK 50,296,1935
rectal rat	lowest published lethal dose: 1,400 mg/kg	N/R	JPETAB 49,36,1933
subcutaneous mouse	lethal dose (50 percent kill): 2,100 mg/kg	N/R	VCVGK* -,108,1984
subcutaneous rat	lowest published lethal dose: 1,400 mg/kg	N/R	VCVGK* -,108,1984
unreported route man	lowest published lethal dose: 441 mg/kg	N/R	85DCAI 2,73,1970

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published toxic concentration: 1,500 ppm/6 hour/7 day- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	NTIS** OTS0536478

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Occupational Exposure Limit - DENMARK	time-weighted average 100 ppm (360 mg/m³), OCT 2002
Occupational Exposure Limit - POLAND	MAC(time-weighted average) 100 mg/m³, MAC(short term exposure limit) 450 mg/m³, JAN1999

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 82015; Number of Industries 6; Total Number of Facilities 698; Number of Occupations 8; Total Number of Employees Exposed 1,949
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 82015; Number of Industries 2; Total Number of Facilities 10; Number of Occupations 4; Total Number of Employees Exposed 57

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a hypnotic agent
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
85DCAI	"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
AIPTAK	Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
IMSUAI	Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
JPETAB	Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
LDTU**	"Narkoseversuche mit Hoheren Alkoholen und Stickstoffderivaten, Dissertation," Leube, F., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1931
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SAPHAO	Skandinavisches Archiv fuer Physiologie. (Stockholm, Sweden) V.1-83, 1899-1940. For publisher information, see APSCAX.
SCIEAS	Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
VCVGK*	"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.