The Registry of Toxic Effects of Chemical Substances

2 - Pentanone, 4 - methyl -

RTECS #: SA9275000

CAS #: 108-10-1

UPDATE: May 2008 MW: 100.18 MF: C6H12O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Methyl - 4 - pentanone
  2. 4 - Methyl - 2 - pentanon (Czech)
  3. 4 - Methyl - 2 - pentanone
  4. 4 - Methyl - pentan - 2 - on (Dutch, German)
  5. 4 - Metilpentan - 2 - one (Italian)
  6. Hexon (Czech)
  7. Hexone
  8. Hexone (OSHA)
  9. Isobutyl methyl ketone
  10. Isobutyl - methylketon (Czech)
  11. Isopropylacetone
  1. Ketone, isobutyl methyl
  2. MIBK
  3. MIK
  4. Methyl isobutyl ketone
  5. Methyl isobutyl ketone (ACGIH:OSHA)
  6. Methyl - isobutyl - cetone (French)
  7. Methylisobutylketon (Dutch, German)
  8. Metilisobutilchetone (Italian)
  9. Metyloizobutyloketon (Polish)
  10. RCRA waste number U161
  11. Shell MIBK


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		200 ppm/15 minute N/R JIHTAB 28,262,1946
eye
rabbit 		40 mg severe UCDS** 4/25/1958
eye
rabbit 		100 µL/24 hour moderate NTIS** OTS0535383
skin
rabbit 		500 mg/24 hour mild 85JCAE -,284,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 3,000 ppm/6 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		FAATDF 8,310,1987
inhalation
mouse 		lowest published toxic concentration: 3,000 ppm/6 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system 		FAATDF 8,310,1987
inhalation
rat 		lowest published toxic concentration: 300 ppm/6 hour (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		FAATDF 8,310,1987
inhalation
rat 		lowest published toxic concentration: 1,000 ppm (70 day male/70 day prior to copulation) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral 		TOXID9 60,250,2001
inhalation
rat 		lowest published toxic concentration: 2,000 ppm (70 day male/70 day prior to copulation) Reproductive: Effects on newborn: Biochemical and metabolic TOXID9 60,250,2001
inhalation
rat 		lowest published toxic concentration: 500 ppm (70 day male/70 day prior to copulation) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 60,250,2001
inhalation
rat 		lowest published toxic concentration: 1,000 ppm (multigeneration) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral 		TOXID9 60,250,2001
inhalation
rat 		lowest published toxic concentration: 2,000 ppm (multigeneration) Reproductive: Effects on newborn: Biochemical and metabolic TOXID9 60,250,2001
inhalation
rat 		lowest published toxic concentration: 500 ppm (multigeneration) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 60,250,2001
inhalation
rat 		lowest published toxic concentration: 2,000 ppm (multigeneration) Reproductive: Effects on newborn: Behavioral IJTOFN 23,127,2004


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published lethal concentration: 68,900 mg/m3/3 hour Eye: Other eye effects

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes 		NTIS** OTS0535383
inhalation
human 		lowest published toxic concentration: 800 mg/m3 Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Cough 		VCVGK* -,426,1994
inhalation
human 		lowest published toxic concentration: 4,100 mg/m3 Brain and Coverings: Other degenerative changes

Behavioral: General anesthetic 		VCVGK* -,426,1994
inhalation
human 		lowest published toxic concentration: 12 mg/m3 Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		GISAAA 5,8,1994
inhalation
man 		lowest published toxic concentration: 2,290 mg/m3 Olfaction: Other olfaction effects NTIS** OTS0535383
inhalation
mouse 		lethal concentration (50 percent kill): 23,300 mg/m3 N/R GTPZAB 17(11),52,1973
inhalation
mouse 		lowest published toxic concentration: 2,000 ppm/6 minute Lung, Thorax, or Respiration: Respiratory depression TOLED5 9,137,1981
inhalation
mouse 		lethal concentration (50 percent kill): 23,300 mg/m3 Brain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration 		VCVGK* -,426,1994
inhalation
mouse 		lowest published lethal concentration: 100,000 mg/m3/40 minute Brain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration 		VCVGK* -,426,1994
inhalation
mouse 		lowest published lethal concentration: 40,000 mg/m3/4 hour Brain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration 		VCVGK* -,426,1994
inhalation
rat 		lethal concentration (50 percent kill): 100 gm/m3 N/R NTIS** OTS0535383
inhalation
rat 		lowest published lethal concentration: 100,000 mg/m3/40 minute Brain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration 		VCVGK* -,426,1994
inhalation
rat 		lowest published lethal concentration: 40,000 mg/m3/4 hour Brain and Coverings: Increased intracranial pressure

Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration 		VCVGK* -,426,1994
inhalation
rat 		lowest published toxic dose: 1,000 ppm/6 hour Behavioral: Somnolence (general depressed activity) IJTOFN 23,127,2004
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 800 mg/kg N/R 38MKAJ 2C,4748,1982
intraperitoneal
mouse 		lethal dose (50 percent kill): 268 mg/kg N/R SCCUR* -,7,1961
intraperitoneal
rat 		lethal dose (50 percent kill): 400 mg/kg N/R 38MKAJ 2C,4748,1982
oral
wild bird 		lethal dose (50 percent kill): 100 mg/kg N/R ENTOX* -,79,2005
oral
guinea pig 		lethal dose (50 percent kill): 1,600 mg/kg N/R 38MKAJ 2C,4748,1982
oral
mouse 		lethal dose (50 percent kill): 1,900 mg/kg N/R NTIS** OTS0535383
oral
mouse 		lethal dose (50 percent kill): 2,850 mg/kg Brain and Coverings: Increased intracranial pressure

Liver: Fatty liver degeneration

Blood: Changes in spleen 		VCVGK* -,426,1994
oral
rat 		lethal dose (50 percent kill): 2,080 mg/kg N/R UCDS** 4/25/1958
oral
rat 		lethal dose (50 percent kill): 4,600 mg/kg Brain and Coverings: Increased intracranial pressure

Liver: Fatty liver degeneration

Blood: Changes in spleen 		VCVGK* -,426,1994
oral
rat 		lowest published toxic dose: 500 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOLED5 136,199,2003
skin
rabbit 		lethal dose : >3 gm/kg N/R NTIS** OTS0535383
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 1,396 mg/kg N/R GISAAA 51(5),61,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 1,996 ppm/6 hour/11 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		FAATDF 9,380,1987
inhalation
mouse 		lowest published toxic concentration: 1,002 ppm/6 hour/14 week- intermittent Liver: Changes in liver weight FAATDF 9,380,1987
inhalation
mouse 		: 1,800 ppm/17 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-538
inhalation
mouse 		: 1,800 ppm/104 week- intermittent Kidney, Ureter, and Bladder: Kidney tumors NTPTR* NTP-TR-538
inhalation
mouse 		: 450 ppm/104 week- intermittent Blood: Eosinophilia NTPTR* NTP-TR-538
inhalation
rat 		lowest published toxic concentration: 1,996 ppm/6 hour/11 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		FAATDF 9,380,1987
inhalation
rat 		lowest published toxic concentration: 1,002 ppm/6 hour/14 week- intermittent Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Kidney, Ureter, and Bladder: Other changes in urine composition 		FAATDF 9,380,1987
inhalation
rat 		lowest published toxic concentration: 410 mg/m3/2 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in bladder weight 		NTIS** OTS0535383
inhalation
rat 		lowest published toxic concentration: 410 mg/m3/90 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in bladder weight 		NTIS** OTS0535383
inhalation
rat 		lowest published toxic concentration: 4,210 mg/m3/6 hour/4 week- intermittent Endocrine: Changes in adrenal weight NTIS** OTS0572858
inhalation
rat 		: 1,800 ppm/104 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Kidney tumors 		NTPTR* NTP-TR-538
inhalation
rat 		: 1,800 ppm/104 week- intermittent Endocrine: Adrenal cortex hyperplasia

Blood: Leukemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-538
inhalation
rat 		: 900 ppm/97 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-538
inhalation
rat 		: 900 ppm/104 week- intermittent Kidney, Ureter, and Bladder: Other changes NTPTR* NTP-TR-538
inhalation
rat 		: 450 ppm/104 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Kidney tumors 		NTPTR* NTP-TR-538
inhalation
rat 		lowest published toxic concentration: 2,000 ppm/7 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain IJTOFN 23,127,2004
inhalation
rat 		lowest published toxic concentration: 1,000 ppm/70 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight 		IJTOFN 23,127,2004
oral
rat 		lowest published toxic dose: 9,350 mg/kg/24 day- intermittent Behavioral: Convulsions or effect on seizure threshold

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		GTPZAB 17(11),52,1973
skin
rat 		lowest published toxic dose: 35,700 mg/kg/17 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Nutritional and Gross Metabolic: Body temperature decrease

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		GISAAA 53(10),79,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm;short term exposure limit 75 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
ENTOX* -,79,2005
TOXICOLOGY REVIEW
IJTOFN 23,29,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,322,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (410 mg/m3) DTLVS* 3,126,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (410 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (410 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (410 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (410 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - DENMARK time-weighted average 20 ppm (83 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 83 mg/m3 (20 ppm);
short term exposure limit 208 mg/m3 (50 ppm), FEB 2006
Occupational Exposure Limit - FRANCE VME 20 ppm (83 mg/m3), VLE 50 ppm (208 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 83 mg/m3 (20 mL/m3), 2005
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 50 ppm (200 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 50 ppm (205 mg/m3), short term exposure limit 75 ppm (300 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 50 ppm (205 mg/m3), 2004
Occupational Exposure Limit - MEXICO time-weighted average 75 ppm (307 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 104 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 50 ppm (205 mg/m3);
short term exposure limit 75 ppm (307 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (105 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 200 mg/m3, MAC(short term exposure limit) 300 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 25 ppm (100 mg/m3);
short term exposure limit 50 ppm (200 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 20 ppm (82 mg/m3),KZG- week 40 ppm (164 mg/m3), Skin, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (208 mg/m3);
short term exposure limit 100 ppm (skin), 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ISOBUTYL KETONE-air 10 hour time-weighted average 50 ppm;
short term exposure limit 75 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 37510;
Number of Industries 258;
Total Number of Facilities 42,735;
Number of Occupations 149;
Total Number of Employees Exposed 435,266
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 37510;
Number of Industries 253;
Total Number of Facilities 47,027;
Number of Occupations 150;
Total Number of Employees Exposed 612,921;
Total Number of Female Employees Exposed 110,397


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a solvent, a denaturant and as an extractant
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8704
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones I, 1300
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Carcinogenesis studies; on test (two year studies), October 2000
OSHA ANALYTICAL METHOD #1004


REFERENCES:

CODEN
REFERENCE
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a solvent, a denaturant and as an extractant

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), FIRL, 4/78

NIOSH PROFILE (SPRAY PAINTING), FIRL, 4/78

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), SRI, 2/7

RTECS Compound Description:
   Tumorigen
   Reproductive Effector
   Human Data
   Primary Irritant

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